Wnt/β-catenin(Wnt/β-连环蛋白)
β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer,malignant breast tumors, ovarian and endometrial cancer. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).
Products for Wnt/β-catenin
- Cat.No. 产品名称 Information
- GC16701 SKI II An SPHK1 inhibitor
- GC13658 Wnt-C59 A potent Porcupine inhibitor
- GC11548 Tankyrase Inhibitors (TNKS) 49 Tankyrase inhibitor
- GC15041 Tankyrase Inhibitors (TNKS) 22 Tankyrase inhibitor
- GC17153 CHIR-99021 (CT99021) HCl A selective GSK3 inhibitor
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GC12781
XAV-939
A TNKS inhibitor
- GC16893 ICG 001 An inhibitor of β-catenin/CBP interactions
- GC14572 KY 02111 Induces stem cell differentiation
- GC11674 WIKI4 A potent TNKS1/2 inhibitor
- GC12869 JW 55 A TNKS1/2 inhibitor
- GC14037 Triptonide A diterpenoid with diverse biological activities
- GC18107 Salinomycin sodium salt A selective cancer stem cell inhibitor
- GC14882 Salinomycin A selective cancer stem cell inhibitor
- GC16454 IWP-2 IWP-2 是Wnt信号通路的抑制剂,IC50值为 27 nM。IWP-2还是一种具有ATP竞争能力的Casein Kinase 1δ(CK1δ) 抑制剂,IC50值为40 nM。
- GC12134 FH535 An inhibitor of β-catenin signaling
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GC16702
CHIR-99021 (CT99021)
一种选择性的GSK3抑制剂
- GN10017 Wogonin A flavonoid with anti-inflammatory and antitumor activities