Proteasome(蛋白酶体)
The proteasome is a large multisubunit complex of approximately 2.5 MDa that mediates a wide range of physiological and pathological cellular processes by selectively degrading unnecessary proteins in eukaryotes. The structure of a proteasome is comprised of the catalytic core particle (CP) and two terminal regulatory particles (RPs). The CP (also known as the 20S proteasome) is a barrel shaped multisubunit complex (approximately 750 kDa) consisting of four axially stacked heptameric rings (two outer α-rings and two inner β-rings) with 7 subunits in each ring, where three β subunits (β1, β2 and β5) contain catalytically active threonine residues and are associated with caspase-like, trypsin-like and chymotrypsin-like activities respectively.
- Cat.No. 产品名称 Information
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GC68437
Vimentin-IN-1
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GC67908
Calpain-2-IN-1
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GC65938
Thrombin inhibitor 5
WAY-358871 is a bioactive compound.
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GC65668
5-Amino-8-hydroxyquinoline
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GC65547
(1S,2R)-Alicapistat
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GC65010
Bortezomib-d8
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GC64607
Dazcapistat
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GC64472
20S Proteasome-IN-1
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GC64282
LXE408
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GC64213
GSK3494245
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GC63964
PR-39 TFA
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GC62399
RA375
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GC62239
Zetomipzomib
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GC62210
ONX-0914 TFA
A selective inhibitor of the β5i (LMP7) subunit of the immunoproteasome
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GC62193
(1S,2S)-Bortezomib
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GC61945
PR-924
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GC61221
PTP1B-IN-9
An inhibitor of the ubiquitin-proteasome system
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GC39166
TCH-165
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GA23841
Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde
Z-IE(OtBu)AL-CHO is an inhibitor of chymotrypsin-like activity of the multicatalytic proteinase complex (MPC; 20S proteasome) in HT4 cells. It is the first inhibitor reported so far which can cause accumulation of ubiquitinylated proteins in neuronal cells. Furthermore, this compound induced massive apoptosis in murine leukaemia L1210 cells. Therefore, proteasome inhibitors may be considered as potential anti-neoplastic agents.
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GC37814
Tomatine
Tomatine (Lycopersicin) is a natural glycoalkaloid with fungicidal, antimicrobial, and insecticidal properties.
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GC36872
Pepstatin Trifluoroacetate
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GC36871
Pepstatin Ammonium
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GC36356
Ixazomib citrate
Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively.
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GC35238
Aclacinomycin A hydrochloride
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GC41233
(R)-MG132
A potent proteasome inhibitor
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GC40694
Calpain Inhibitor II
A non-selective cysteine protease inhibitor
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GC34649
LMP7-IN-1
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GC33743
Alicapistat (ABT-957)
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GC33311
Proteasome-IN-1
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GC32815
Capzimin
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GC32765
RA190
RA190, a bis-benzylidine piperidon, is a potent, selective and oral effective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1 with anticancer activity. RA190 triggers ER stress response, p53/p21 signaling axis and autophagy in multiple myeloma cells.
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GC32407
Rpn11-IN-1
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GC31899
KZR-504
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GC31563
FK-448 Free base
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GC16699
HMB-Val-Ser-Leu-VE
A vinyl ester tripeptide inhibitor of proteasome trypsin-like activity
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GC12003
VR23
A proteasome inhibitor
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GC10561
PD 151746
An inhibitor of calpain 1
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GC15802
PI-1840
PI-1840 是一种有效的选择性糜蛋白酶样 (CT-L) 抑制剂,IC50 值为 27 nM。 PI-1840 抑制细胞增殖并将细胞周期阻滞在 G2/M 期。 PI-1840 诱导细胞凋亡并诱导自噬。 PI-1840 诱导蛋白酶体底物 p27、Bax 和 IκB-α 的积累。
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GC16912
PD 150606
An inhibitor of calpains
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GC11640
MDL 28170
A cell permeable, selective calpain inhibitor
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GC17255
Gliotoxin
An immunosuppressive mycotoxin with diverse biological effects
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GC10342
Calpeptin
A calpain inhibitor
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GC10486
Salinosporamide A (NPI-0052, Marizomib)
An orally bioactive proteasome inhibitor
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GC15778
ONX-0914 (PR-957)
A selective inhibitor of the β5i (LMP7) subunit of the immunoproteasome
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GC12784
Artemether (SM-224)
An antiparasitic compound
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GC13711
Gabexate mesylate
A serine protease inhibitor
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GC12272
CEP-18770
An inhibitor of chymotrypsin-like proteasome activity
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GC16146
MLN2238
A 20S proteasome inhibitor and an active metabolite of MLN9708
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GC13718
MLN9708
A prodrug form of MLN2238
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GC15517
MG-262
A proteasome inhibitor with diverse biological activities