Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Proteasome


The proteasome is a large multisubunit complex of approximately 2.5 MDa that mediates a wide range of physiological and pathological cellular processes by selectively degrading unnecessary proteins in eukaryotes. The structure of a proteasome is comprised of the catalytic core particle (CP) and two terminal regulatory particles (RPs). The CP (also known as the 20S proteasome) is a barrel shaped multisubunit complex (approximately 750 kDa) consisting of four axially stacked heptameric rings (two outer α-rings and two inner β-rings) with 7 subunits in each ring, where three β subunits (β1, β2 and β5) contain catalytically active threonine residues and are associated with caspase-like, trypsin-like and chymotrypsin-like activities respectively.

  1. Cat.No. 产品名称 Information
  2. GC68437 Vimentin-IN-1
  3. GC67908 Calpain-2-IN-1
  4. GC65938 Thrombin inhibitor 5 WAY-358871 is a bioactive compound.
  5. GC65668 5-Amino-8-hydroxyquinoline
  6. GC65547 (1S,2R)-Alicapistat
  7. GC65010 Bortezomib-d8
  8. GC64607 Dazcapistat
  9. GC64472 20S Proteasome-IN-1
  10. GC64282 LXE408
  11. GC64213 GSK3494245
  12. GC63964 PR-39 TFA
  13. GC62399 RA375
  14. GC62239 Zetomipzomib
  15. GC62210 ONX-0914 TFA A selective inhibitor of the β5i (LMP7) subunit of the immunoproteasome
  16. GC62193 (1S,2S)-Bortezomib
  17. GC61945 PR-924
  18. GC61221 PTP1B-IN-9 An inhibitor of the ubiquitin-proteasome system
  19. GC39166 TCH-165
  20. GA23841 Z-Ile-Glu(OtBu)-Ala-Leu-aldehyde Z-IE(OtBu)AL-CHO is an inhibitor of chymotrypsin-like activity of the multicatalytic proteinase complex (MPC; 20S proteasome) in HT4 cells. It is the first inhibitor reported so far which can cause accumulation of ubiquitinylated proteins in neuronal cells. Furthermore, this compound induced massive apoptosis in murine leukaemia L1210 cells. Therefore, proteasome inhibitors may be considered as potential anti-neoplastic agents.
  21. GC37814 Tomatine Tomatine (Lycopersicin) is a natural glycoalkaloid with fungicidal, antimicrobial, and insecticidal properties.
  22. GC36872 Pepstatin Trifluoroacetate
  23. GC36871 Pepstatin Ammonium
  24. GC36356 Ixazomib citrate Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively.
  25. GC35238 Aclacinomycin A hydrochloride
  26. GC41233 (R)-MG132

    A potent proteasome inhibitor

  27. GC40694 Calpain Inhibitor II A non-selective cysteine protease inhibitor
  28. GC34649 LMP7-IN-1
  29. GC33743 Alicapistat (ABT-957)
  30. GC33311 Proteasome-IN-1
  31. GC32815 Capzimin
  32. GC32765 RA190 RA190, a bis-benzylidine piperidon, is a potent, selective and oral effective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1 with anticancer activity. RA190 triggers ER stress response, p53/p21 signaling axis and autophagy in multiple myeloma cells.
  33. GC32407 Rpn11-IN-1
  34. GC31899 KZR-504
  35. GC31563 FK-448 Free base
  36. GC16699 HMB-Val-Ser-Leu-VE A vinyl ester tripeptide inhibitor of proteasome trypsin-like activity
  37. GC12003 VR23 A proteasome inhibitor
  38. GC10561 PD 151746 An inhibitor of calpain 1
  39. GC15802 PI-1840 PI-1840 是一种有效的选择性糜蛋白酶样 (CT-L) 抑制剂,IC50 值为 27 nM。 PI-1840 抑制细胞增殖并将细胞周期阻滞在 G2/M 期。 PI-1840 诱导细胞凋亡并诱导自噬。 PI-1840 诱导蛋白酶体底物 p27、Bax 和 IκB-α 的积累。
  40. GC16912 PD 150606 An inhibitor of calpains
  41. GC11640 MDL 28170 A cell permeable, selective calpain inhibitor
  42. GC17255 Gliotoxin An immunosuppressive mycotoxin with diverse biological effects
  43. GC10342 Calpeptin A calpain inhibitor
  44. GC10486 Salinosporamide A (NPI-0052, Marizomib) An orally bioactive proteasome inhibitor
  45. GC15778 ONX-0914 (PR-957) A selective inhibitor of the β5i (LMP7) subunit of the immunoproteasome
  46. GC12784 Artemether (SM-224) An antiparasitic compound
  47. GC13711 Gabexate mesylate A serine protease inhibitor
  48. GC12272 CEP-18770 An inhibitor of chymotrypsin-like proteasome activity
  49. GC16146 MLN2238 A 20S proteasome inhibitor and an active metabolite of MLN9708
  50. GC13718 MLN9708 A prodrug form of MLN2238
  51. GC15517 MG-262 A proteasome inhibitor with diverse biological activities

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