Neuropeptide FF/AF Receptors(神经肽 FF/AF 受体)

Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in the control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.

Neuropeptide Y (NPY) is a potent orexigenic neuropeptide, and antagonism of NPY Y1 and NPY Y5 receptors (NPYxR) is considered a potentially important anti-obesity drug target.

Neuropeptide Y (NPY) is widely distributed in the human body and contributes to a vast number of physiological processes. A number of other uses for modulators of NPY receptors have been implied in a range of diseases.

Cat.No. 产品名称 Information
GC63855 Peptide YY (PYY) (3-36), porcine TFA
GC61875 Neuropeptide Y (3-36) (human, rat) An endogenous C-terminal NPY fragment
GC61530 BIBO3304 TFA
BIBO3304 TFA has subnanomolar affinity for both the human and the rat neuropeptide Y (NPY) Y1 receptor with IC50 values of 0.38±0.06 nM and 0.72±0.42 nM, respectively.
GC61499 Neuropeptide Y (human) (TFA)
GC60322 RF9 hydrochloride An NPFF receptor antagonist
GA23511 Spexin Spexin 是一种保守的肽，起神经递质/神经调节剂和内分泌因子的作用。
GA20229 (Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) (Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) 是一种特异性的神经肽 Y Y1 受体激动剂。
GA20195 (Gly¹,Ser³·²²,Gln⁴·³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³·³¹,Aib³²)-Pancreatic Polypeptide (human) (Gly¹,Ser³.²²,Gln⁴.³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³.³¹,Aib³²)-Pancreatic Polypeptide (human)是一种有效的选择性神经肽 Y Y5 受体激动剂，与 hY5 受体结合的 IC50 为 0.24 nM。
GC36728 Neuropeptide Y 22-36
GC36261 HT-2157 A GAL₃ receptor antagonist
GC36102 Galanin Receptor Ligand M35
GC34270 Neuropeptide Y (29-64), amide, human TFA
GC34222 Galanin (1-16), mouse, porcine, rat TFA
GC33785 Pancreatic Polypeptide, rat (Rat pancreatic polypeptide)
GC31338 Velneperit (S2367) An antagonist of NPY receptor Y₅
GC31335 MK-0557 An antagonist of NYP receptor Y₅
GC31165 Neuropeptide Y (29-64), amide, human (Human neuropeptide Y (29-64)) A key neuropeptide of the gut-brain axis
GC31161 Neuropeptide Y(29-64)
GC31154 Neuropeptide Y (13-36), amide, human (Neuropeptide Y (13-36), human)
GC30947 Galanin (1-16), mouse, porcine, rat
GC30931 Galantide
GC30721 FR252384
GC30456 Pancreatic Polypeptide, bovine
GC30452 Peptide YY (PYY), human
GC14612 JNJ-31020028 An antagonist of NPY receptor Y₂
GC17307 CYM 9484 CYM 9484 是一种选择性和高效的神经肽 Y (NPY) Y2 受体拮抗剂，IC50 值为 19 nM。
GC14430 JNJ 5207787 An antagonist of NPY receptor Y₂
GC14881 BMS 193885 Competitive NPY Y1 receptor antagonist
GC10167 CGP 71683 hydrochloride An antagonist of NPY receptor Y₅
GC17424 BIIE 0246 BIIE 0246 是一种有效且高度选择性的非肽神经肽 Y (NPY) Y2 受体拮抗剂，IC50 为 15 nM。
GC16987 L-152,804 L-152,804 是一种具有口服活性的选择性神经肽 Y Y5 受体 (NPY5-R) 拮抗剂，对 hY5 的 Ki 值为 26 nM。
GC14112 RFRP 3 (human) RFRP-3 (Neuropeptide VF(124-131))(human) 是一种人类 GnIH 肽同源物，是一种通过抑制 Ca2+ 动员来有效抑制促性腺激素分泌的抑制剂。
GC13864 Neuropeptide SF (mouse, rat) Neuropeptide SF (mouse,rat) 是一种有效的神经肽 FF 受体激动剂，对 NPFF1 和 NPFF2 的 Ki 值分别为 48.4 nM 和 12.1 nM。
GC12648 Neuropeptide FF A neuropeptide and agonist of NPFF1 and NPFF2 receptors
GC15408 Neuropeptide AF (human) Neuropeptide AF（人）是一种内源性抗阿片肽。
GC15633 Neuropeptide SF (human) Endogenous antiopiate neuropeptide
GC13167 Pancreatic Polypeptide (human) An NPY receptor agonist
GC15469 RF 9 An NPFF receptor antagonist
GC13801 M40 M40 是一种有效的、非选择性的甘丙肽受体拮抗剂。
GC10862 Galanin (1-30) (human) Galanin (1-30) (human) 是一种 30 个氨基酸的神经肽，作为\u200b\u200b GalR1 和 GalR2 受体的激动剂，Kis 均为 1 nM。