Neuropeptide FF/AF Receptors(神经肽 FF/AF 受体)
Neuropeptide Y receptors are a class of G-protein coupled receptors which are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide. These receptors are involved in the control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.
Neuropeptide Y (NPY) is a potent orexigenic neuropeptide, and antagonism of NPY Y1 and NPY Y5 receptors (NPYxR) is considered a potentially important anti-obesity drug target.
Neuropeptide Y (NPY) is widely distributed in the human body and contributes to a vast number of physiological processes. A number of other uses for modulators of NPY receptors have been implied in a range of diseases.
- Cat.No. 产品名称 Information
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GC63855
Peptide YY (PYY) (3-36), porcine TFA
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GC61875
Neuropeptide Y (3-36) (human, rat)
An endogenous C-terminal NPY fragment
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GC61530
BIBO3304 TFA
BIBO3304 TFA has subnanomolar affinity for both the human and the rat neuropeptide Y (NPY) Y1 receptor with IC50 values of 0.38±0.06 nM and 0.72±0.42 nM, respectively.
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GC61499
Neuropeptide Y (human) (TFA)
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GC60322
RF9 hydrochloride
An NPFF receptor antagonist
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GA23511
Spexin
Spexin 是一种保守的肽,起神经递质/神经调节剂和内分泌因子的作用。
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GA20229
(Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat)
(Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) 是一种特异性的神经肽 Y Y1 受体激动剂。
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GA20195
(Gly¹,Ser³·²²,Gln⁴·³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³·³¹,Aib³²)-Pancreatic Polypeptide (human)
(Gly¹,Ser³.²²,Gln⁴.³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³.³¹,Aib³²)-Pancreatic Polypeptide (human)是一种有效的选择性神经肽 Y Y5 受体激动剂,与 hY5 受体结合的 IC50 为 0.24 nM。
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GC36728
Neuropeptide Y 22-36
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GC36261
HT-2157
A GAL3 receptor antagonist
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GC36102
Galanin Receptor Ligand M35
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GC34270
Neuropeptide Y (29-64), amide, human TFA
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GC34222
Galanin (1-16), mouse, porcine, rat TFA
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GC33785
Pancreatic Polypeptide, rat (Rat pancreatic polypeptide)
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GC31338
Velneperit (S2367)
An antagonist of NPY receptor Y5
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GC31335
MK-0557
An antagonist of NYP receptor Y5
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GC31165
Neuropeptide Y (29-64), amide, human (Human neuropeptide Y (29-64))
A key neuropeptide of the gut-
brain axis -
GC31161
Neuropeptide Y(29-64)
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GC31154
Neuropeptide Y (13-36), amide, human (Neuropeptide Y (13-36), human)
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GC30947
Galanin (1-16), mouse, porcine, rat
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GC30931
Galantide
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GC30721
FR252384
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GC30456
Pancreatic Polypeptide, bovine
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GC30452
Peptide YY (PYY), human
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GC14612
JNJ-31020028
An antagonist of NPY receptor Y2
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GC17307
CYM 9484
CYM 9484 是一种选择性和高效的神经肽 Y (NPY) Y2 受体拮抗剂,IC50 值为 19 nM。
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GC14430
JNJ 5207787
An antagonist of NPY receptor Y2
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GC14881
BMS 193885
Competitive NPY Y1 receptor antagonist
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GC10167
CGP 71683 hydrochloride
An antagonist of NPY receptor Y5
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GC17424
BIIE 0246
BIIE 0246 是一种有效且高度选择性的非肽神经肽 Y (NPY) Y2 受体拮抗剂,IC50 为 15 nM。
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GC16987
L-152,804
L-152,804 是一种具有口服活性的选择性神经肽 Y Y5 受体 (NPY5-R) 拮抗剂,对 hY5 的 Ki 值为 26 nM。
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GC14112
RFRP 3 (human)
RFRP-3 (Neuropeptide VF(124-131))(human) 是一种人类 GnIH 肽同源物,是一种通过抑制 Ca2+ 动员来有效抑制促性腺激素分泌的抑制剂。
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GC13864
Neuropeptide SF (mouse, rat)
Neuropeptide SF (mouse,rat) 是一种有效的神经肽 FF 受体激动剂,对 NPFF1 和 NPFF2 的 Ki 值分别为 48.4 nM 和 12.1 nM。
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GC12648
Neuropeptide FF
A neuropeptide and agonist of NPFF1 and NPFF2 receptors
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GC15408
Neuropeptide AF (human)
Neuropeptide AF(人)是一种内源性抗阿片肽。
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GC15633
Neuropeptide SF (human)
Endogenous antiopiate neuropeptide
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GC13167
Pancreatic Polypeptide (human)
An NPY receptor agonist
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GC15469
RF 9
An NPFF receptor antagonist
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GC13801
M40
M40 是一种有效的、非选择性的甘丙肽受体拮抗剂。
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GC10862
Galanin (1-30) (human)
Galanin (1-30) (human) 是一种 30 个氨基酸的神经肽,作为\u200b\u200b GalR1 和 GalR2 受体的激动剂,Kis 均为 1 nM。