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BAX (the BCL-2-associated X protein), a cardinal pro-apoptotic member of the BCL-2 family, is a latent, cytosolic and monomeric protein that plays an important role in the mitochondria-dependent apoptotic pathway. The nuclear magnetic resonance (NMR) spectroscopic analysis suggests that the structure of Bax consists of nine α-helices (α1 to α9) connected by short loops, in which α5, α6 and α9 are involved in the interaction of Bax with outer mitochondrial membrane (OMM). Bax remains inactive in cytosol and goes through conformational changes triggered by a cell death signal to insert, oligomerize and form large pores through the OMM with the releasing of different apoptogenic factors.

Products for  Bax

  1. Cat.No. 产品名称 Information
  2. GC11247 PRIMA-1MET A re-activator of the apoptotic function of mutant p53 proteins
  3. GC12086 PRIMA-1 A re-activator of the apoptotic function of mutant p53 proteins
  4. GC16695 Bax inhibitor peptide, negative control Peptide inhibit Bax translocation to mitochondria
  5. GC17195 Bax inhibitor peptide V5 A Bax inhibitor
  6. GC16023 Bax inhibitor peptide P5 Bax inhibitor
  7. GC12763 Bax channel blocker Bax 通道阻滞剂是 BAX(一种凋亡调节剂)的选择性变构抑制剂。 Bax 通道阻滞剂直接与 BAX 结合并变构抑制 BAX 活化。 Bax 通道阻滞剂具有研究由 BAX 依赖性细胞死亡介导的疾病的潜力。
  8. GC12053 BAM7 A direct activator of Bax

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