Home >> Signaling Pathways >> Apoptosis >> Bax

Bax

BAX (the BCL-2-associated X protein), a cardinal pro-apoptotic member of the BCL-2 family, is a latent, cytosolic and monomeric protein that plays an important role in the mitochondria-dependent apoptotic pathway. The nuclear magnetic resonance (NMR) spectroscopic analysis suggests that the structure of Bax consists of nine α-helices (α1 to α9) connected by short loops, in which α5, α6 and α9 are involved in the interaction of Bax with outer mitochondrial membrane (OMM). Bax remains inactive in cytosol and goes through conformational changes triggered by a cell death signal to insert, oligomerize and form large pores through the OMM with the releasing of different apoptogenic factors.

  1. Cat.No. 产品名称 Information
  2. GC11247 PRIMA-1MET PRIMA-1MET (APR-246) 是一种一流的小分子,可在 TP53 突变细胞中恢复野生型 p53 功能。 PRIMA-1MET 触发肿瘤细胞凋亡。 PRIMA-1MET 还针对硒蛋白硫氧还蛋白还原酶 1 (TrxR1),它是细胞氧化还原平衡的关键调节剂。
  3. GC12086 PRIMA-1 PRIMA-1 (NSC-281668) 是一种突变型 p53 再激活剂,可恢复 TP53 突变型甲状腺癌细胞对组蛋白甲基化抑制剂 3-Deazaneplanocin A 的敏感性。
  4. GC16695 Bax inhibitor peptide, negative control Peptide inhibit Bax translocation to mitochondria
  5. GC17195 Bax inhibitor peptide V5 Bax 抑制剂肽 V5 (BIP-V5) 是一种 Bax 介导的细胞凋亡抑制剂,用于癌症治疗。
  6. GC16023 Bax inhibitor peptide P5 Bax inhibitor
  7. GC12763 Bax channel blocker Bax 通道阻滞剂是 BAX(一种凋亡调节剂)的选择性变构抑制剂。 Bax 通道阻滞剂直接与 BAX 结合并变构抑制 BAX 活化。 Bax 通道阻滞剂具有研究由 BAX 依赖性细胞死亡介导的疾病的潜力。
  8. GC12053 BAM7 BAM7 是促凋亡 BAX 的直接选择性激活剂,IC50 为 3.3 μM。

7 Item(s)

per page

Set Descending Direction