Oxytocin Receptors(催产素受体)
Oxytocin, a hormone involved in numerous physiologic processes, plays a central role in the mechanisms of parturition and lactation. It acts through its receptor, which is a transmembrane receptor belonging to the rhodopsin-type class I G-protein-coupled receptor (GPCR) superfamily, while Gq/phospholipase C (PLC)/inositol 1,4,5-triphosphate (InsP3) is the main pathway via which it exerts its action in the myometrium. The main signaling pathway is the Gq/LPC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. Various peptide and nonpeptide antagonists have been developed as potential tocolytic agents or research tools for the various Oxytocin functions. Many of these oxytocin receptor antagonists are used only as pharmacological tools, while others have tocolytic action.
- Cat.No. 产品名称 Information
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GC12194
Atosiban
An oxytocin receptor antagonist
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GC39849
Atosiban acetate
An oxytocin receptor antagonist
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GC11419
Carbetocin
A peptide oxytocin receptor agonist
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GC30594
Epelsiban (GSK 557296)
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GC16620
L-368,899 hydrochloride
A non-peptide oxytocin receptor antagonist
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GC11991
L-371,257
L-371,257 是一种口服生物可利用的、非血脑屏障渗透剂、选择性和竞争性催产素受体 (pA2=8.4) 拮抗剂,对催产素受体 (Ki=19 nM) 和加压素 V1a 受体 (Ki=3.7) 具有高亲和力nM)。
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GC63036
L-372662
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GC38922
LIT-001
LIT-001 trifluoroacetate(LIT-001 TFA) is the first nonpeptide oxytocin receptor (OXTR) agonist that improves social interaction in a mouse model of autism.
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GC32425
OT antagonist 1
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GC34364
OT antagonist 1 demethyl derivative
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GC32431
OT antagonist 3
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GC36823
OT-R antagonist 1
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GC33540
OT-R antagonist 2 (Oxytocin receptor antagonist 2)
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GC16222
Oxytocin
A peptide hormone best known for its role in reproductive biology
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GC44526
Oxytocin (acetate)
A peptide hormone best known for its role in reproductive biology
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GC17249
PF-3274167
An oxytocin receptor antagonist
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GC31068
Retosiban (GSK 221149)
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GC37635
SHR1653
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GC14001
TC OT 39
oxytocin receptor partial agonist
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GC11042
WAY 267464 dihydrochloride
WAY 267464 dihydrochloride 是一种非肽催产素受体 (OTR) 激动剂。