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Oxytocin Receptors(催产素受体)

Oxytocin, a hormone involved in numerous physiologic processes, plays a central role in the mechanisms of parturition and lactation. It acts through its receptor, which is a transmembrane receptor belonging to the rhodopsin-type class I G-protein-coupled receptor (GPCR) superfamily, while Gq/phospholipase C (PLC)/inositol 1,4,5-triphosphate (InsP3) is the main pathway via which it exerts its action in the myometrium. The main signaling pathway is the Gq/LPC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. Various peptide and nonpeptide antagonists have been developed as potential tocolytic agents or research tools for the various Oxytocin functions. Many of these oxytocin receptor antagonists are used only as pharmacological tools, while others have tocolytic action.

  1. Cat.No. 产品名称 Information
  2. GC12194 Atosiban An oxytocin receptor antagonist
  3. GC39849 Atosiban acetate An oxytocin receptor antagonist
  4. GC11419 Carbetocin A peptide oxytocin receptor agonist
  5. GC30594 Epelsiban (GSK 557296)
  6. GC16620 L-368,899 hydrochloride A non-peptide oxytocin receptor antagonist
  7. GC11991 L-371,257 L-371,257 是一种口服生物可利用的、非血脑屏障渗透剂、选择性和竞争性催产素受体 (pA2=8.4) 拮抗剂,对催产素受体 (Ki=19 nM) 和加压素 V1a 受体 (Ki=3.7) 具有高亲和力nM)。
  8. GC63036 L-372662
  9. GC38922 LIT-001 LIT-001 trifluoroacetate(LIT-001 TFA) is the first nonpeptide oxytocin receptor (OXTR) agonist that improves social interaction in a mouse model of autism.
  10. GC32425 OT antagonist 1
  11. GC34364 OT antagonist 1 demethyl derivative
  12. GC32431 OT antagonist 3
  13. GC36823 OT-R antagonist 1
  14. GC33540 OT-R antagonist 2 (Oxytocin receptor antagonist 2)
  15. GC16222 Oxytocin A peptide hormone best known for its role in reproductive biology
  16. GC44526 Oxytocin (acetate) A peptide hormone best known for its role in reproductive biology
  17. GC17249 PF-3274167 An oxytocin receptor antagonist
  18. GC31068 Retosiban (GSK 221149)
  19. GC37635 SHR1653
  20. GC14001 TC OT 39 oxytocin receptor partial agonist
  21. GC11042 WAY 267464 dihydrochloride WAY 267464 dihydrochloride 是一种非肽催产素受体 (OTR) 激动剂。

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