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Oxytocin Receptors(催产素受体)

Oxytocin, a hormone involved in numerous physiologic processes, plays a central role in the mechanisms of parturition and lactation. It acts through its receptor, which is a transmembrane receptor belonging to the rhodopsin-type class I G-protein-coupled receptor (GPCR) superfamily, while Gq/phospholipase C (PLC)/inositol 1,4,5-triphosphate (InsP3) is the main pathway via which it exerts its action in the myometrium. The main signaling pathway is the Gq/LPC/Ins3 pathway, but the MAPK and the RhoA/Rho kinase pathways are also activated, contributing to increased prostaglandin production and direct contractile effect on myometrial cells. Various peptide and nonpeptide antagonists have been developed as potential tocolytic agents or research tools for the various Oxytocin functions. Many of these oxytocin receptor antagonists are used only as pharmacological tools, while others have tocolytic action.

Products for  Oxytocin Receptors

  1. Cat.No. 产品名称 Information
  2. GC12194 Atosiban

    阿托西班; RW22164; RWJ22164

    An oxytocin receptor antagonist
  3. GC39849 Atosiban acetate

    醋酸阿托西班; RW22164 acetate; RWJ22164 acetate

    An oxytocin receptor antagonist
  4. GC11419 Carbetocin


    A peptide oxytocin receptor agonist
  5. GC30594 Epelsiban (GSK 557296)

    GSK 557296

    Epelsiban (GSK 557296) (GSK 557296) 是一种有效的、选择性的和口服生物可利用的催产素受体拮抗剂,对人催产素受体的 pKi 为 9.9。
  6. GC16620 L-368,899 hydrochloride A non-peptide oxytocin receptor antagonist
  7. GC11991 L-371,257 L-371,257 是一种口服生物可利用的、非血脑屏障渗透剂、选择性和竞争性催产素受体 (pA2=8.4) 拮抗剂,对催产素受体 (Ki=19 nM) 和加压素 V1a 受体 (Ki=3.7) 具有高亲和力nM)。
  8. GC63036 L-372662 L-372662 是一种有效的具有口服活性的非肽催产素拮抗剂,其 Ki 值为 4.8。野生型 hOTR 和[A318G]OTR 的 L-372662 的 Kd 值分别为 5.8 nM 和 73 nM。L-372,662 对 OTR:V1a 具有选择性。
  9. GC38922 LIT-001 LIT-001 trifluoroacetate(LIT-001 TFA) is the first nonpeptide oxytocin receptor (OXTR) agonist that improves social interaction in a mouse model of autism.
  10. GC32425 OT antagonist 1 OTantagonist1(Compound4)是一种有效的选择性催产素(Oxytocin)拮抗剂,Ki为50nM。
  11. GC34364 OT antagonist 1 demethyl derivative OTantagonist1demethylderivative是OTantagonist1的去甲基化产物.OTantagonist1(Compound4)是一种有效的选择性催产素(Oxytocin)拮抗剂,Ki为50nM。
  12. GC32431 OT antagonist 3 OTantagonist3是一种催产素(oxytocin,OT)拮抗剂,详细信息请参考专利文献WO2007017752A1。
  13. GC36823 OT-R antagonist 1

    Oxytocin receptor antagonist 1

    OT-R antagonist 1是一种新型有效的选择性非肽类OT-R拮抗剂, 抑制催产素诱发的细胞内Ca2+活动(IC50=8nM)。
  14. GC33540 OT-R antagonist 2 (Oxytocin receptor antagonist 2)

    Oxytocin receptor antagonist 2

    OT-R 拮抗剂 2(催产素受体拮抗剂 2)是一种非肽类低分子量 OT-R 拮抗剂。
  15. GC16222 Oxytocin


    A peptide hormone best known for its role in reproductive biology
  16. GC44526 Oxytocin (acetate)

    醋酸催产素; 醋酸缩宫素; α-Hypophamine acetate; Oxytocic hormone acetate

    A peptide hormone best known for its role in reproductive biology

  17. GC17249 PF-3274167 An oxytocin receptor antagonist
  18. GC31068 Retosiban (GSK 221149)

    GSK 221149; GSK 221149A

    Retosiban (GSK 221149) (GSK221149A) 是一种有效的选择性催产素拮抗剂,Ki 为 0.65 nM。
  19. GC37635 SHR1653 SHR1653是强效的、选择性的、能透过大脑的催产素受体 (OTR) 的拮抗剂,对hOTR 的 IC50 值为 15 nM。
  20. GC14001 TC OT 39 oxytocin receptor partial agonist
  21. GC11042 WAY 267464 dihydrochloride WAY 267464 dihydrochloride 是一种非肽催产素受体 (OTR) 激动剂。
  22. GC68698 [Asp5]-Oxytocin [Asp5]-Oxytocin 是一种高效力的 5 位 (5-position)-神经垂体激素类似物。[Asp5]-Oxytocin 可引起体外大鼠子宫收缩,并能够被镁离子增强。[Asp5]-Oxytocin 具有大鼠子宫收缩素、禽血管抑制剂和大鼠抗利尿剂的能力。

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