Bcl-2 Family(Bcl-2蛋白家族)
Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.
- Cat.No. 产品名称 Information
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GC25673
Obatoclax (GX15-070)
Obatoclax (GX15-070) is an antagonist of Bcl-2 with an Ki of 0
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GC66021
TP-021
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GC66017
Mcl-1 inhibitor 6
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GC64674
ABBV-167
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GC64467
Lisaftoclax
APG-2575 (lisaftoclax) is a dual Bcl-2 and Bcl-xl inhibitor with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively.
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GC63769
PROTAC Bcl-xL degrader-2
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GC63531
S65487 sulfate
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GC63426
S65487 hydrochloride
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GC63325
Bcl-xL antagonist 2
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GC63083
MSN-50
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GC62871
BM-1244
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GC62707
Murizatoclax
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GC62599
BCL6-IN-4
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GC62561
CCT369260
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GC62554
S65487
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GC62505
Pelcitoclax
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GC61096
MSN-125
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GC60111
Clitocine
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GC38943
PROTAC Mcl1 degrader-1
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GC38941
PROTAC Bcl2 degrader-1
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GC38928
MCL-1/BCL-2-IN-3
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GC38927
MCL-1/BCL-2-IN-2
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GC38811
Mcl1-IN-8
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GC38617
Dihydrokaempferol
A flavone with diverse biological activities
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GC38014
BT2
An Mcl-1 inhibitor
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GC37780
Thevetiaflavone
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GC36855
Paris saponin VII
Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.
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GC36559
Mcl1-IN-9
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GC36558
Mcl1-IN-12
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GC36557
Mcl1-IN-11
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GC36556
Mcl1-IN-1
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GC35882
dMCL1-2
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GC35001
(S)-Gossypol acetic acid
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GC34980
(E)-Ferulic acid
Trans-ferulic acid is a potent activator of AMPKunder high glucose condition.
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GC34389
PUMA BH3
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GC34263
Bak BH3
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GC34134
Glycocholic acid
A glycine-conjugated form of cholic acid
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GC34096
(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid))
(R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.
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GC33407
BM 957
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GC33401
S55746 hydrochloride (BLC201 (hydrochloride))
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GC33364
Mcl1-IN-4
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GC33347
Mcl1-IN-3
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GC33312
ML311
An Mcl-1 inhibitor
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GC33295
MIK665 (S-64315)
An Mcl-1 inhibitor
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GC33283
AZD-5991 Racemate
AZD5991 is a macrocyclic MCL-1 inhibitor with sub-nanomolar affinity for MCL-1 (Ki = 0.13 nM). The binding affinity of AZD5991 is about 25-fold lower for mouse Mcl-1 vs. human Mcl-1 but only four-fold lower for rat Mcl-1.
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GC33255
AZD4320
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GC33247
AZD-5991
An Mcl-1 inhibitor
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GC33239
AZD-5991 S-enantiomer
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GC33052
VU0661013
VU661013 is a novel, potent, selective MCL1 inhibitor with Ki of 97 ± 30 pM of human MCL-1 in a TR-FRET assay. However, VU661013 does not significantly inhibit BCL-xL or BCL-2 with Ki > 40 μM or = 0.73 μM. VU661013 de-stabilizes BIM/MCL-1 association, leads to apoptosis in AML.
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GC33035
Mcl1-IN-2