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Home >> Signaling Pathways >> Apoptosis >> Bcl-2 Family

Bcl-2 Family(Bcl-2蛋白家族)

Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.

  1. Cat.No. 产品名称 Information
  2. GC25673 Obatoclax (GX15-070) Obatoclax (GX15-070) is an antagonist of Bcl-2 with an Ki of 0
  3. GC66021 TP-021
  4. GC66017 Mcl-1 inhibitor 6
  5. GC64674 ABBV-167
  6. GC64467 Lisaftoclax APG-2575 (lisaftoclax) is a dual Bcl-2 and Bcl-xl inhibitor with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively.
  7. GC63769 PROTAC Bcl-xL degrader-2
  8. GC63531 S65487 sulfate
  9. GC63426 S65487 hydrochloride
  10. GC63325 Bcl-xL antagonist 2
  11. GC63083 MSN-50
  12. GC62871 BM-1244
  13. GC62707 Murizatoclax
  14. GC62599 BCL6-IN-4
  15. GC62561 CCT369260
  16. GC62554 S65487
  17. GC62505 Pelcitoclax
  18. GC61096 MSN-125
  19. GC60111 Clitocine
  20. GC38943 PROTAC Mcl1 degrader-1
  21. GC38941 PROTAC Bcl2 degrader-1
  22. GC38928 MCL-1/BCL-2-IN-3
  23. GC38927 MCL-1/BCL-2-IN-2
  24. GC38811 Mcl1-IN-8
  25. GC38617 Dihydrokaempferol A flavone with diverse biological activities
  26. GC38014 BT2 An Mcl-1 inhibitor
  27. GC37780 Thevetiaflavone
  28. GC36855 Paris saponin VII Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.
  29. GC36559 Mcl1-IN-9
  30. GC36558 Mcl1-IN-12
  31. GC36557 Mcl1-IN-11
  32. GC36556 Mcl1-IN-1
  33. GC35882 dMCL1-2
  34. GC35001 (S)-Gossypol acetic acid
  35. GC34980 (E)-Ferulic acid Trans-ferulic acid is a potent activator of AMPKunder high glucose condition.
  36. GC34389 PUMA BH3
  37. GC34263 Bak BH3
  38. GC34134 Glycocholic acid A glycine-conjugated form of cholic acid
  39. GC34096 (R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) (R)-(-)-Gossypol (AT-101) acetic acid, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. AT-101 simultaneously triggers apoptosis and a cytoprotective type of autophagy. Phase 2.
  40. GC33407 BM 957
  41. GC33401 S55746 hydrochloride (BLC201 (hydrochloride))
  42. GC33364 Mcl1-IN-4
  43. GC33347 Mcl1-IN-3
  44. GC33312 ML311 An Mcl-1 inhibitor
  45. GC33295 MIK665 (S-64315) An Mcl-1 inhibitor
  46. GC33283 AZD-5991 Racemate AZD5991 is a macrocyclic MCL-1 inhibitor with sub-nanomolar affinity for MCL-1 (Ki = 0.13 nM). The binding affinity of AZD5991 is about 25-fold lower for mouse Mcl-1 vs. human Mcl-1 but only four-fold lower for rat Mcl-1.
  47. GC33255 AZD4320
  48. GC33247 AZD-5991 An Mcl-1 inhibitor
  49. GC33239 AZD-5991 S-enantiomer
  50. GC33052 VU0661013 VU661013 is a novel, potent, selective MCL1 inhibitor with Ki of 97 ± 30 pM of human MCL-1 in a TR-FRET assay. However, VU661013 does not significantly inhibit BCL-xL or BCL-2 with Ki > 40 μM or = 0.73 μM. VU661013 de-stabilizes BIM/MCL-1 association, leads to apoptosis in AML.
  51. GC33035 Mcl1-IN-2

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