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Home >> Signaling Pathways >> Apoptosis >> Bcl-2 Family

Bcl-2 Family(Bcl-2蛋白家族)

Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.

Products for  Bcl-2 Family

  1. Cat.No. 产品名称 Information
  2. GC33295 MIK665 (S-64315) An Mcl-1 inhibitor
  3. GC33283 AZD-5991 Racemate AZD5991 is a macrocyclic MCL-1 inhibitor with sub-nanomolar affinity for MCL-1 (Ki = 0.13 nM). The binding affinity of AZD5991 is about 25-fold lower for mouse Mcl-1 vs. human Mcl-1 but only four-fold lower for rat Mcl-1.
  4. GC33255 AZD4320 AZD4320是BH-3的新型类似物，有效的BCL2/BCLxL的双重抑制剂。AZD4320对于KPUM-MS3，KPUM-UH1，和STR-428细胞系的IC50分别为26nM，17nM，和170nM。
  5. GC33247 AZD-5991 An Mcl-1 inhibitor
  6. GC33239 AZD-5991 S-enantiomer AZD-5991S-enantiomer是AZD-5991的低活性S型对映体。AZD-5991S-enantiomer是一种Mcl-1抑制剂，FRET实验检测的IC50为6.3μM，SPR实验检测的Kd为0.98μM。
  7. GC33052 VU0661013 VU661013 is a novel, potent, selective MCL1 inhibitor with Ki of 97 ± 30 pM of human MCL-1 in a TR-FRET assay. However, VU661013 does not significantly inhibit BCL-xL or BCL-2 with Ki > 40 μM or = 0.73 μM. VU661013 de-stabilizes BIM/MCL-1 association, leads to apoptosis in AML.
  8. GC33035 Mcl1-IN-2 Mcl1-IN-2 是骨髓细胞因子 1 (Mcl-1) 的抑制剂。 Mcl1-IN-2 是一种非竞争性的德里 metallo-β-lactamase (NDM-1) 抑制剂。 MCL1-IN-2对Metallo-&7#8946; -lactamases NDM-1，IMP-4，IMIS和L1的IC50S是0.4637 &##956; M，M，3.980 &&####&&7778777878787878787878787878787878787878787787877年7月778.7887;offlineefficient_models_2022q2.md
  9. GC32998 Ginsenoside Rh4 Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.
  10. GC32981 A-385358 A-385358是Bcl-XL的一个选择性抑制剂，对于Bcl-XL和Bcl-2的Ki值分别为0.80和67nM。
  11. GC32947 S55746 (BLC201) S55746 (S 055746,BCL201) is a novel, orally active BCL-2 specific inhibitor (Ki = 1.3 nM) with poor affinity for BCL-XL and no significant binding to MCL-1, BFL-1 (BCL2A1/A1). The selectivity of S55746 for BCL-2 versus BCL-XL ranges from ~70 to 400 folds.
  12. GC31806 Bz 423 (BZ48) Bz 423 (BZ48) 是一种促凋亡的 1,4-苯二氮卓类药物，在狼疮小鼠模型中具有治疗特性，显示出对自身反应性淋巴细胞的选择性，并激活 Bax 和 Bak。
  13. GC19452 AMG-176 AMG-176 (AMG-176) 是一种有效的、选择性的、具有口服活性的 MCL-1 抑制剂，Ki 为 0.13 nM。
  14. GC10661 Destruxin B An insecticidal mycotoxin
  15. GC17513 A-1331852 A Bcl-xL inhibitor
  16. GC17512 A-1155463 A Bcl-xL inhibitor
  17. GC18136 BH3I-1 An inhibitor of anti-apoptotic Bcl-2 proteins
  18. GC12621 S63845 An Mcl-1 inhibitor
  19. GC16278 A-1210477 A selective Mcl-1 inhibitor
  20. GC10721 BDA-366 A Bcl2-BH4 domain antagonist
  21. GC11140 Radotinib(IY-5511) A selective Bcr-Abl tyrosine kinase inhibitor
  22. GC17008 (+)-Apogossypol (+)-Apogossypol 是一种泛 BCL-2 拮抗剂。 (+)-Apogossypol 与 Mcl-1、Bcl-2 和 Bcl-xL 结合，EC50 分别为 2.6、2.8 和 3.69 μM。
  23. GC12902 Pyridoclax Pyridoclax 是一种潜在的 Mcl-1 抑制剂。
  24. GC15805 UMI-77 A selective Mcl-1 inhibitor
  25. GC10567 TCPOBOP An agonist for mouse CAR
  26. GC15480 Marinopyrrole A An alkaloid with antibacterial activity
  27. GC13317 WEHI-539 hydrochloride A selective Bcl-xL inhibitor
  28. GC16938 Muristerone A An ecdysteroid receptor agonist
  29. GC15400 MIM1 An Mcl-1 inhibiting molecule
  30. GC12046 iMAC2 iMAC2 是一种有效的 MAC 抑制剂，IC50 为 28 nM，LD50 为 15000 nM。
  31. GC15987 BIM, Biotinylated

    Bim peptide fragment with a biotin moiety attached
  32. GC16695 Bax inhibitor peptide, negative control Peptide inhibit Bax translocation to mitochondria
  33. GC17195 Bax inhibitor peptide V5 A Bax inhibitor
  34. GC16023 Bax inhibitor peptide P5 Bax inhibitor
  35. GC12763 Bax channel blocker Bax 通道阻滞剂是 BAX（一种凋亡调节剂）的选择性变构抑制剂。 Bax 通道阻滞剂直接与 BAX 结合并变构抑制 BAX 活化。 Bax 通道阻滞剂具有研究由 BAX 依赖性细胞死亡介导的疾病的潜力。
  36. GC12258 2,3-DCPE hydrochloride 2,3-DCPE 是一种促凋亡化合物，对癌细胞\u003cem\u003e相对于\u003c/em\u003e正常人细胞具有选择性
  37. GC11921 WEHI-539 A selective Bcl-xL inhibitor
  38. GC12139 Gambogic Acid A xanthonoid with anticancer activity
  39. GC13065 Chelerythrine Chloride Potent inhibitor of PKC and Bcl-xL
  40. GC12053 BAM7 A direct activator of Bax
  41. GC11106 AT-101 AT-101 (AT-101) 是天然产物棉酚的左旋异构体。 AT-101 与 Bcl-2、Mcl-1 和 Bcl-xL 蛋白结合，Kis 分别为 260±30 nM、170±10 nM 和 480±40 nM。
  42. GC10153 Sabutoclax A pan-Bcl-2 inhibitor
  43. GC14080 Apogossypolone (ApoG2) Apogossypolone (ApoG2) (ApoG2) 是一种具有口服活性的 Bcl-2 家族蛋白抑制剂，对 Bcl-2、Mcl-1 和 Bcl-XL 的 Ki 值分别为 35、25 和 660 nM。
  44. GC11569 Obatoclax mesylate (GX15-070) An antagonist of pro-survival Bcl-2 proteins
  45. GC13498 BM-1074 BM-1074 是一种有效且特异性的 Bcl-2/Bcl-xL 抑制剂，对 Bcl-2 和 Bcl-xL 的 Ki 值 < 1 nM，IC50 值分别为 1.8 nM 和 6.9 nM。 BM-1074 诱导细胞凋亡，并对四种小细胞肺癌细胞系（H146、H1963、H187 和 H1417）具有抗增殖活性，IC50 值为 1-2 nM。
  46. GC12649 TW-37 An inhibitor of the Bcl-2 family proteins
  47. GC12405 ABT-263 (Navitoclax) An inhibitor of Bcl-2 family proteins
  48. GC17234 ABT-737 An inhibitor of anti-apoptotic Bcl-2 proteins
  49. GC14069 ABT-199 A Bcl-2 inhibitor
  50. GN10082 Gossypol A natural polyphenol with diverse effects
  51. GN10341 Acetate gossypol 棉酚乙酸 ((±)-Gossypol-乙酸) 与 Bcl-xL 蛋白和 Bcl-2 蛋白结合，Kis 分别为 0.5-0.6 μM 和 0.2-0.3 mM。

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