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Destruxin B Sale

(Synonyms: 黑僵菌素 B) 目录号 : GC10661

An insecticidal mycotoxin

Destruxin B Chemical Structure

Cas No.:2503-26-6

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1mg
¥8,153.00
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产品描述

Destruxin B, a cyclic hexadepsipeptide mycotoxin, has been reported to have insecticidal and phytotoxic activity and can also induce apoptosis.

Mycotoxins has been identified as a class of toxic secondary metabolites produced by organisms of the fungus kingdom and are able to cause disease and death in both humans and animals.

In vitro: The results of a previous study showed that destruxin B exhibited selective and significant time- and dose-dependent inhibitory effects on the viabilities of GNM and TSCCa cells but not on GF cells. These findings indicated that destruxin B was able to induce tumor specific growth inhibition in cancer cells through Bax/Bcl-2-mediated intrinsic mitochondrial apoptotic pathway in both time- and dose-dependent manners [1].

In vivo: Animal study found that the daily subcutaneously administered destruxin B at 0.6-15 mg/kg was safe and effective in inhibiting the growth of CRC cells. In addition, the expression of cleaved poly (ADP-ribose) polymerase, Bax, as well as active caspase-3 were observed with destruxin B treatment. Moreover, the increase in tumor volumes of destruxin B treated groups were significantly lower than those of the mock-treated group [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Huang Liu R, Chen SP, Lu TM, Tsai WY, Tsai CH, Yang CC1, Tzeng YM.  Selective apoptotic cell death effects of oral cancer cells treated with destruxin B. BMC Complement Altern Med. 2014 Jun 28;14:207. doi: 10.1186/1472-6882-14-207.
[2] Lee YP, Wang CW, Liao WC, Yang CR, Yeh CT, Tsai CH, Yang CC, Tzeng YM.  In vitro and in vivo anticancer effects of destruxin B on human colorectal cancer. Anticancer Res. 2012 Jul;32(7):2735-45.

Chemical Properties

Cas No. 2503-26-6 SDF
别名 黑僵菌素 B
化学名 cyclo[N-methyl-L-alanyl-β-alanyl-(2R)-2-hydroxy-4-methylpentanoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl]
Canonical SMILES O=C(N[C@]([C@@H](C)CC)([H])C(N(C)[C@@H](C(C)C)C(N(C)[C@H]1C)=O)=O)[C@@]2([H])N(CCC2)C([C@@H](CC(C)C)OC(CCNC1=O)=O)=O
分子式 C30H51N5O7 分子量 593.8
溶解度 ≤10mg/ml in dichloromethane,;10mg/ml in methanol;10mg/ml in ethyl acetate 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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1 mg 5 mg 10 mg
1 mM 1.6841 mL 8.4203 mL 16.8407 mL
5 mM 0.3368 mL 1.6841 mL 3.3681 mL
10 mM 0.1684 mL 0.842 mL 1.6841 mL
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