Ras(Ras蛋白)
Ras belongs to a class of small GTPase and is involved in transmitting signals within cells.
- Cat.No. 产品名称 Information
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GC66473
ESI-08
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GC66020
ZINC69391
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GC66001
RBC10
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GC65904
KRAS G12C inhibitor 28
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GC65873
SOS1-IN-14
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GC65480
ARS-1323-alkyne
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GC65270
Digeranyl bisphosphonate
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GC65263
SOS1-IN-11
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GC65032
KRpep-2d TFA
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GC64964
MRTX-1257
A covalent inhibitor of K-RasG12C
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GC64784
GGTI-286 hydrochloride
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GC64723
Garsorasib
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GC64657
(E/Z)-ZINC09659342
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GC64558
KRA-533
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GC64510
GDC-6036
GDC-6036 is a KRAS G12C inhibitor that binds irreversibly to switch II pocket of KRAS G12C (when in the inactive GDP-bound state) thereby blocking GTP binding and activation.
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GC64452
MRTX-EX185
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GC64447
KRpep-2d
KRpep-2d is a K-Ras(G12D) selective inhibitory cyclic peptide with selectivity against wild-type (WT) K-Ras and the K-Ras(G12C) mutant. The IC50 value is 1.6 nM.
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GC64442
KRAS G12C inhibitor 14
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GC64365
MRTX0902
MRTX0902 is a potent SOS1 inhibitor for therapeutic intervention of KRAS-driven cancers with an IC50 of 46 nM.
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GC64341
ASP2453
ASP2453, a potent, selective and covalent KRAS G12C inhibitor, inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf. ASP2453 is a potential therapeutic agent for KRAS G12C-mutated cancer.
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GC64216
GGTI-286
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GC63875
KRAS G12C inhibitor 15
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GC63647
Rasarfin
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GC63564
JDQ-443
JDQ443, a potent and selective, orally bioavailable covalent inhibitor of GDP-bound KRASG12C with an IC50 of 0.012 ?M for inhibition of c-Raf recruitment.
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GC63562
RM-018
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GC63079
MRTX1133 formic
An inhibitor of K-RasG12D
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GC62699
MRTX1133
MRTX1133 是一种非共价、有效和选择性的 KRAS G12D 抑制剂。 MRTX1133 以最佳方式填充开关 II 口袋并延伸三个取代基以有利地与蛋白质相互作用,导致对 KRAS G12D 的估计 KD 为 0.2 pM。 MRTX1133 阻止 SOS1 催化的核苷酸交换和/或 KRAS G12D/GTP/RAF1 复合物的形成,从而抑制突变的 KRAS 依赖性信号转导。 MRTX1133 选择性抑制 KRAS G12D 突变体,但不抑制 KRAS 野生型肿瘤细胞。 MRTX1133 在细胞试验中具有个位数的纳摩尔活性,并且在含有 KRAS G12D 突变的肿瘤模型中具有显着的体内功效。
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GC62622
K-Ras G12C-IN-4
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GC62504
RAS/RAS-RAF-IN-1
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GC62494
RMC-0331
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GC62486
KRAS inhibitor-10
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GC62421
RAS inhibitor Abd-7
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GC62347
CMC2.24
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GC62238
Sotorasib
Sotorasib (AMG510) is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.This AMG510 is a chiral compound.
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GC62227
KRAS G12D inhibitor 1
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GC61766
LC-2
LC-2 is a first PROTAC capable of degrading endogenous KRASG12C with DC50s between 0.25 μM and 0.76 μM. LC-2 covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling.
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GC46893
Atranorin
A depside lichen metabolite with diverse biological activities
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GC61076
MLS000532223
MLS000532223 is a high affinity, selective inhibitor of Rho family GTPases with EC50 ranging from 16 μM to 120 μM.
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GC60969
KRAS inhibitor-9
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GC60533
6H05 (TFA)
An allosteric inhibitor of oncogenic K-Ras(G12C)
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GC39763
Z62954982
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GC50609
SAH-SOS1A
SAH-SOS1A 是一种基于肽的 SOS1/KRAS 蛋白相互作用抑制剂。 SAH-SOS1A 以纳摩尔级亲和力 (EC50=106-175 nM) 与野生型和突变型 KRAS(G12D、G12V、G12C、G12S 和 Q61H)结合,直接且独立地阻断核苷酸结合,削弱 KRAS 驱动的癌细胞活力,并通过机制阻断 KRAS 下游的 ERK-MAPK 磷酸信号级联发挥其作用。
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GC38942
PROTAC K-Ras Degrader-1
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GC38898
CCG-222740
CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression.
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GC38400
MRTX849
A covalent inhibitor of K-RasG12C
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GC37973
ZT-12-037-01
ZT-12-037-01 is a specific and ATP-competitive STK19 inhibitor with IC50s of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. It displays extremely high kinase selectivity using KINOMEscan against a panel of 468 diverse kinases using an in vitro ATP-site competition binding assay at 1 μM.
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GC36901
PHT-7.3
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GC36599
Methylophiopogonanone B
An isoflavone with diverse biological activities
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GC36400
K-Ras G12C-IN-3
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GC36399
K-Ras G12C-IN-2