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Aminopeptidases are a group of enzymes widely distributed among bacteria, fungi, animals and plants that catalyze the cleavage of amino acids from the amino terminus of protein or peptide substrates through hydrolysis of peptide bonds near the N-terminal end of a polypeptide chain.  Most aminopeptidases are assembled by relatively high mass (50kDa) subunits exhibiting multimeric structures, whereas some are monomeric. The majority of aminopeptidases are zinc metalloenzymes and hence inhibited by the transition-state analog bestatin.  Aminopeptidases have been found in many subcellular organelles as well as in cytoplasm and membrane, where they are involved in diverse proteolytic pathways and play an essential role in protein maturation, degradation of non-hormonal and hormonal peptides and possibly determination of protein stability.

  1. Cat.No. 产品名称 Information
  2. GC67997 Aminopeptidase-IN-1 Aminopeptidase-IN-1 (compound 16o) 是一种有效的胰岛素调节氨肽酶 (IRAP) 抑制剂,Ki 为 7.7 μM。Aminopeptidase-IN-1 可用于研究认知和记忆障碍。
  3. GC63435 LTA4H-IN-1 An inhibitor of LTA4 hydrolase
  4. GC62113 Firibastat Firibastat (QGC001) 是一种口服活性的 EC33 前体药物。Firibastat 是一种首创的脑氨基肽酶 A (APA) 抑制剂 (Ki=200 nM),选择性和特异性地抑制高血压大鼠脑血管紧张素 II 转化为血管紧张素 III,并降低血压。
  5. GC36733 NGR peptide Trifluoroacetate NGR peptide Trifluoroacetate 是含有天冬酰胺-甘氨酸-精氨酸 (NGR) 基序的肽,NGR peptide (NGR 肽) 可靶向肿瘤新生血管上皮细胞特异过量表达的 CD13 受体。
  6. GC35499 Bestatin trifluoroacetate An aminopeptidase inhibitor
  7. GC42777 Amastatin (hydrochloride) An aminopeptidase inhibitor
  8. GC34613 HFI-142 HFI-142是胰岛素调节性氨基肽酶(IRAP)抑制剂,ki值为2.01μM。
  9. GC18471 DG-051 An LTA4 hydrolase inhibitor
  10. GC16350 Actinonin An aminopeptidase inhibitor
  11. GC15577 Bestatin hydrochloride An aminopeptidase inhibitor
  12. GC10171 Puromycin aminonucleoside

    A glomerular epithelial cell toxin

  13. GC10406 Tosedostat (CHR2797) An aminopeptidase inhibitor
  14. GC11780 Bestatin An aminopeptidase inhibitor

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