Aminopeptidase(氨肽酶)
Aminopeptidases are a group of enzymes widely distributed among bacteria, fungi, animals and plants that catalyze the cleavage of amino acids from the amino terminus of protein or peptide substrates through hydrolysis of peptide bonds near the N-terminal end of a polypeptide chain. Most aminopeptidases are assembled by relatively high mass (50kDa) subunits exhibiting multimeric structures, whereas some are monomeric. The majority of aminopeptidases are zinc metalloenzymes and hence inhibited by the transition-state analog bestatin. Aminopeptidases have been found in many subcellular organelles as well as in cytoplasm and membrane, where they are involved in diverse proteolytic pathways and play an essential role in protein maturation, degradation of non-hormonal and hormonal peptides and possibly determination of protein stability.
- Cat.No. 产品名称 Information
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GC67997
Aminopeptidase-IN-1
Aminopeptidase-IN-1 (compound 16o) 是一种有效的胰岛素调节氨肽酶 (IRAP) 抑制剂,Ki 为 7.7 μM。Aminopeptidase-IN-1 可用于研究认知和记忆障碍。
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GC63435
LTA4H-IN-1
An inhibitor of LTA4 hydrolase
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GC62113
Firibastat
Firibastat (QGC001) 是一种口服活性的 EC33 前体药物。Firibastat 是一种首创的脑氨基肽酶 A (APA) 抑制剂 (Ki=200 nM),选择性和特异性地抑制高血压大鼠脑血管紧张素 II 转化为血管紧张素 III,并降低血压。
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GC36733
NGR peptide Trifluoroacetate
NGR peptide Trifluoroacetate 是含有天冬酰胺-甘氨酸-精氨酸 (NGR) 基序的肽,NGR peptide (NGR 肽) 可靶向肿瘤新生血管上皮细胞特异过量表达的 CD13 受体。
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GC35499
Bestatin trifluoroacetate
An aminopeptidase inhibitor
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GC42777
Amastatin (hydrochloride)
An aminopeptidase inhibitor
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GC34613
HFI-142
HFI-142是胰岛素调节性氨基肽酶(IRAP)抑制剂,ki值为2.01μM。
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GC18471
DG-051
An LTA4 hydrolase inhibitor
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GC16350
Actinonin
An aminopeptidase inhibitor
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GC15577
Bestatin hydrochloride
An aminopeptidase inhibitor
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GC10171
Puromycin aminonucleoside
A glomerular epithelial cell toxin
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GC10406
Tosedostat (CHR2797)
An aminopeptidase inhibitor
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GC11780
Bestatin
An aminopeptidase inhibitor