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Bombesin Receptors

Bombesin, a peptide of 14 amino acids, is an amphibian homolog to the mammalian gastrin-releasing peptide (GRP), that has been extensively studied as a targeting ligand for diagnosis and therapy of GRP positive tumors, such as breast, pancreas, lungs and prostate cancers. Bombesin binds to and activates G-protein coupled receptors, known as gastrin releasing peptide receptor (GRPR).

Bombesin, a tetradecapeptide isolated from the skin of the frog Bombina bombina, have shown broad spectrum of biological activities. The BBS activates three G protein-coupled receptors: bombesin receptor 1 (BB1), bombesin receptor 2 (BB2), and bombesin receptor 3 (BB3). BBS-like peptides-Neuromedin B (NB) and gastrin releasing peptide (GRP) are natural ligand of the BB1 and BB2 receptors, respectively.

In mammals, BBS receptors and BBS-like peptides are distributed in the Central Nervous System (CNS) including regions involved in the cardiorespiratory control.

The mammalian bombesin G-protein-coupled receptor subfamily comprises three structurally related members, the receptors for neuromedin B (NMBR or BB1), gastrin-releasing peptide (GRPR or BB2), and bombesin receptor subtype-3 (BRS-3 or BB3).

Bombesin receptor subtype-3 (BRS-3) is an orphan G protein-coupled receptor implicated in the regulation of energy homeostasis.

  1. Cat.No. Product Name Information
  2. GC14908 Alytesin Amphibian bombesin-like peptide
  3. GC50215 BA 1 Potent bombesin agonist
  4. GC60619 BA 1 TFA BA1TFAisapotentbombesinreceptoragonist(IC50valuesare0.26,1.55and2.52nMforBB1,BB2andBB3respectively).BA1TFAenhancesglucosetransportinobeseanddiabeticprimarymyocytes.BA1TFAalsostimulatesNCI-H1299lungcancercellproliferationinvitro.
  5. GC15165 BIM 187 Bombesin/GRP receptor agonist
  6. GC14279 BIM 189 Bombesin antagonist
  7. GC17080 BIM 23042 Antagonist of neuromedin B receptor,selective
  8. GC11620 BIM 23127 Antagonist of neuromedin B receptor
  9. GC14014 Bombesin Neuropeptide with many biological effects
  10. GC16415 GRP (human) agonist for the gastrin-releasing peptide receptor (GRPR)
  11. GC16854 GRP (porcine) agonist for the gastrin-releasing peptide receptor (GRPR)
  12. GC36404 Kuwanon G Kuwanon G 是从桑树中得到的黄酮类化合物,为蛙皮素受体 (bombesin receptor) 拮抗剂,具有杀菌作用。
  13. GC38510 Kuwanon H Kuwanon H 是桑白皮中的黄酮类化合物,为非肽类蛙皮素受体 (bombesin receptor) 拮抗剂。Kuwanon H 可特异性抑制细胞内胃泌激素释放肽 CRP 与(GRP-preferring recepotr) 受体的结合,Ki 值为 290 nM。
  14. GC14662 Litorin Amphibian bombesin-like peptide
  15. GC19413 MK-5046 MK-5046 is a novel BRS-3 agonist, binds to BRS-3 with high affinity (mouse Ki = 1.6 nM, human Ki = 25 nM).
  16. GC33152 ML-18 ML-18是一种抑制肺癌生长的非肽铃蟾肽受体亚型-3(BRS-3)拮抗剂。
  17. GC12707 Neuromedin B (porcine) Mammalian bombesin-like peptide and endogenous ligand for the neuromedin B receptor
  18. GC16376 Neuromedin C (porcine) Mammalian bombesin-like neuropeptide
  19. GC13768 PD 176252

    gastrin-releasing peptide receptor (GRP-R, BB2) and neuromedin B receptor (NMB-R, BB1) antagonist

  20. GC37072 RC-3095 RC-3095 是一种蛙皮素 (bombesin)/胃泌素 (gastrin) 释放肽受体拮抗剂。
  21. GC17156 [D-Phe12,Leu14]-Bombesin Bombesin receptor antagonist

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