PI3K
PI3K (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
- Cat.No. 产品名称 Information
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GC26044
VPS34 inhibitor 1 (Compound 19)
VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34 with an IC50 of 15 nM.
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GC25913
Selective PI3Kδ Inhibitor 1 (compound 7n)
Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM].
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GC67954
PI3K-IN-36
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GC66463
PI3K/Akt/mTOR-IN-2
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GC66447
PI3K/mTOR Inhibitor-4
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GC65969
CHMFL-PI3KD-317
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GC65534
Boc-L-cyclobutylglycine
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GC65507
AZD8154
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GC65442
Musk ketone
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GC65309
GSK-F1
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GC65199
PI3Kδ-IN-1
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GC65149
AZD3458
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GC64992
YH-306
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GC64938
AZD-7648
An inhibitor of DNA-PK
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GC64778
Gilmelisib
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GC64612
GSK251
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GC64223
Sophocarpine monohydrate
An alkaloid with diverse biological activities
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GC64035
Hirsutenone
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GC63391
CYH33 methanesulfonate
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GC63017
IHMT-PI3Kδ-372
IHMT-PI3Kδ-372 is a potent and selective phosphatidylinositol 3-kinase δ (PI3Kδ) inhibitor with an IC50 of 14 nM in the biochemical assay.
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GC62973
FD223
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GC62593
Parsaclisib hydrochloride
Parsaclisib (INCB050465, IBI376) Hydrochloride is a potent and highly selective PI3Kδ(PI3K delta) inhibitor with an IC50 of 1 nM at 1 mM ATP in biochemical assay and approximately 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.
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GC62572
hSMG-1 inhibitor 11e
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GC62556
PF-06843195
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GC62521
PI3Kα-IN-4
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GC62495
DS-7423
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GC62480
Zandelisib
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GC62465
Idelalisib D5
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GC62456
SRX3207
SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 blocks tumor immunosuppression and increases anti-tumor immunity.
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GC62450
(S)-PI3Kα-IN-4
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GC62376
iMDK quarterhydrate
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GC62342
TASP0415914
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GC62340
PIK-108
PIK-108 is a non-ATP competitive, allosteric p110β/p110δ selective inhibitor.
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GC62335
AZ2
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GC62164
BAY1082439
An inhibitor of PI3Kα, PI3Kβ, and PI3Kδ
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GC62141
NVS-PI3-4
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GC62140
PKI-179
A dual PI3K and mTOR inhibitor
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GC61925
hSMG-1 inhibitor 11j
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GC61227
Quercetin D5
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GC60782
Disitertide TFA
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GC60339
SKI V
SKI V is a noncompetitive and potent inhibitor of non-lipid sphingosine kinase with IC50 of 2 μM for GST-hSK. SKI-V also inhibits PI3K with IC50 of 6 μM for hPI3k. SKI-V decreases formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) and induces apoptosis with antitumor activity.
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GC50332
TC KHNS 11
强效选择性 PI 3-激酶 δ;抑制剂;口服生物利用度
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GC38694
Erucic acid
A 22-
carbon monounsaturated fatty acid -
GC38606
Glaucocalyxin A
Glaucocalyxin A is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx with antitumor and anti-inflammatory activity. Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells.
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GC38482
Desmethylglycitein
An active metabolite of daidzein
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GC38473
WYE-687 dihydrochloride
An mTOR inhibitor
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GC38401
rac-AZD 6482
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GC38392
Euscaphic acid
A triterpene with diverse biological activities
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GC38236
Esculetin
A coumarin with diverse actions
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GC38168
Heterophyllin B
Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla, which provides a novel strategy for the treatment of esophageal cancer.