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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling >> PI3K

PI3K

PI3K (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.

Products for  PI3K

  1. Cat.No. 产品名称 Information
  2. GC30884 LX2343 An inhibitor of BACE1 and PI3K
  3. GC30156 Brevianamide F (Cyclo(L-Pro-L-Trp)) An alkaloid with diverse biological activities
  4. GC19471 Leniolisib An inhibitor of PI3Kδ
  5. GC19411 IITZ-01 IITZ-01 是一种有效的溶酶体自噬抑制剂，具有单剂抗肿瘤活性，对 PI3Kγ 的 IC50 为 2.62 μM。
  6. GC19355 Umbralisib A PI3K p110δ inhibitor
  7. GC19328 SF2523 A dual inhibitor of PI3K and BRD4
  8. GC19300 PQR309 A pan inhibitor of PI3Ks and an inhibitor of mTOR
  9. GC19283 PF-04979064 PF-04979064 是一种有效的选择性 PI3K/mTOR 双激酶抑制剂，对 PI3Kα 和 mTOR 的 Kis 分别为 0.13 nM 和 1.42 nM。
  10. GC19256 MTX-211 MTX-211 (Mol 211) 是 EGFR 和 PI3K 的双重抑制剂，IC50 值 <100 nM。 MTX-211可用于癌症和其他疾病的研究。
  11. GC19202 IPI549 An inhibitor of PI3Kγ
  12. GC19161 GDC-0326 A selective inhibitor of PI3Kα
  13. GC19145 ETP-46321 ETP-46321 是一种有效且具有口服生物利用度的 PI3Kα 和 PI3Kδ 抑制剂，Kiapps 分别为 2.3 和 14.2 nM。
  14. GC19109 CNX-1351 A PI3Kα inhibitor
  15. GC18479 SAR260301 A selective PI3Kβ inhibitor
  16. GC18164 UCB9608 UCB9608 是一种有效、选择性和口服活性的 PI4KIIIβ 抑制剂，IC50 为 11 nM，对 PI3KC2 α、β 和 γ 脂质激酶具有选择性。
  17. GC10228 GDC-0084 PI3K and mTOR inhibitor, brain-permeable
  18. GC15595 GSK2269557 A selective inhibitor of PI3Kδ
  19. GC11910 AS-041164 Selective inhibitor of PI3Kγ
  20. GC12416 INK1117

    A selective inhibitor of PI3Kα
  21. GC12889 PX 866 An inhibitor of PI3K
  22. GC10436 VPS34-IN1 A potent and selective inhibitor of Vps34
  23. GC11248 AZD8835 An inhibitor of PI3Kα and PI3Kδ
  24. GC15679 GSK2292767 A potent and selective inhibitor of PI3Kδ
  25. GC14679 PIK-III A selective inhibitor of Vps34
  26. GC14371 LY3023414 LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ , PI3Kγ, DNA-PK 和 mTOR, 分别。 LY3023414 在低纳摩尔浓度下有效抑制 mTORC1/2。
  27. GC13913 AMG319 Potent, selective PI3Kδ inhibitor
  28. GC12576 AZD8186 A PI3Kβ/δ inhibitor
  29. GC12375 PF-4989216 An orally bioavailable PI3K inhibitor
  30. GC10860 Acalisib (GS-9820) An inhibitor of p110δ
  31. GC17338 GNE-317 A dual PI3Kα and mTOR inhibitor
  32. GC11471 SAR405 A selective inhibitor of Vps34
  33. GC10340 GNE-477 A dual PI3K and mTOR inhibitor
  34. GC15423 GNE-493 A dual inhibitor of PI3K and mTOR
  35. GC16713 HS-173 A PI3K inhibitor
  36. GC10386 PI 828

    A PI3K inhibitor
  37. GC13503 iMDK iMDK 是一种有效的 PI3K 抑制剂，可抑制生长因子 MDK（也称为中期因子或 MK）。 iMDK 与 MEK 抑制剂协同抑制非小细胞肺癌 (NSCLC)，而不会伤害正常细胞和小鼠。
  38. GC10070 CGS 15943 A potent adenosine receptor antagonist
  39. GC16157 740 Y-P

    PI 3-激酶活化剂，可穿透细胞膜。
  40. GC15310 PI-3065 A potent, selective inhibitor of p110δ
  41. GC14318 CAY10505 Inhibitor of PI3Kγ
  42. GC16231 TG100713 An inhibitor of PI3K
  43. GC13612 PIK-294 A potent inhibitor of p110δ
  44. GC15982 PIK-293 A selective inhibitor of p110δ
  45. GC12080 AS-604850 A selective inhibitor of PI3Kγ
  46. GC13901 AS-252424 A potent, selective inhibitor of PI3-kinase γ
  47. GC11868 CH5132799 An inhibitor of class I PI3K isoforms
  48. GC17766 BAY 80-6946 (Copanlisib) A selective PI3K inhibitor
  49. GC13321 WYE-687 An mTOR inhibitor
  50. GC17109 GSK2636771

    A selective inhibitor of PI3K p110β
  51. GC17967 GDC-0032 A potent PI3K inhibitor that is β-sparing

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