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Notch(Notch信号通路)

Notch is a family of transmembrane proteins with repeated extracellular EGF domains and the notch (or DSL) domains.

  1. Cat.No. 产品名称 Information
  2. GC25838 RBPJ Inhibitor-1 (RIN1) RBPJ Inhibitor-1 (RIN1) is a potent inhibitor of the transcription factor RBPJ that disrupts the interaction between NOTCH and RBPJ.
  3. GC64922 Rovalpituzumab
  4. GC64536 Notch 1 TFA
  5. GC64378 Valproic acid-d6
  6. GC50703 Yhhu 3792 Notch signaling pathway activator; enhances the self-renewal capability of neural stem cells (NSCs) via Notch signaling pathway activation in vitro and in vivo
  7. GC61233 RBPJ Inhibitor-1 RBPJ Inhibitor-1 (RIN1) is a potent inhibitor of the transcription factor RBPJ that disrupts the interaction between NOTCH and RBPJ.
  8. GC18533 ZLDI-8 ZLDI-8 是一种 Notch 激活/切割酶 ADAM-17 抑制剂,可抑制 Notch 蛋白的切割。 ZLDI-8 降低促存活/抗凋亡和上皮间质转化 (EMT) 相关蛋白的表达。 ZLDI-8 还是一种竞争性且不可逆的酪氨酸磷酸酶 (Lyp) 抑制剂,IC50 为 31.6 μM,Ki 为 26.22 μM。 ZLDI-8 抑制 MHCC97-H 细胞的生长,IC50 为 5.32 μM。
  9. GC50470 SAHM1 SAHM1 是一种类似于主脑样 (MAML) 的显性阴性形式的肽模拟物,可抑制典型的 Notch 转录复合物形成。
  10. GC38745 CB-103 An inhibitor of Notch signaling
  11. GC36362 Jagged-1 188-204
  12. GC36361 Jagged-1 (188-204) TFA
  13. GC36304 IMR-1A IMR-1A, an acid metabolite of IMR-1, is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. IMR-1A exhibits anti-tumor activity.
  14. GC35612 Carvacrol A monoterpene with diverse biological activities
  15. GC35559 Bruceine D Bruceine D, isolated from Brucea javanica (L.) Merr. (Simaroubaceae), shows antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway.
  16. GC35537 BMS-983970
  17. GC35535 BMS-906024
  18. GC34635 JI051
  19. GC31268 tCFA15
  20. GC14847 Psoralidin A furanocoumarin with anti-cancer activity
  21. GC12741 IMR-1 An inhibitor of Maml1 recruitment to chromatin
  22. GC15896 Z-Ile-Leu-aldehyde Z-Ile-Leu-aldehyde (Z-IL-CHO) 是一种有效的、竞争性的 γ-分泌酶和缺口肽醛抑制剂。
  23. GC11424 Valproic acid A class I HDAC inhibitor
  24. GC10211 FLI-06 A Notch inhibitor
  25. GC12653 LY3039478 A Notch inhibitor
  26. GC15794 Valproic acid sodium salt (Sodium valproate) A class I HDAC inhibitor
  27. GC13673 BMS-708163 (Avagacestat) A potent inhibitor of γ-secretase
  28. GC12191 LY-411575 A γ-secretase inhibitor
  29. GC17671 YO-01027 (Dibenzazepine, DBZ) An inhibitor of γ-secretase
  30. GC16197 RO4929097

    An inhibitor of γ-secretase

  31. GN10797 Tangeretin Polymethoxylated flavone
  32. GC12096 Semagacestat (LY450139) A pan γ-secretase inhibitor

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