Notch(Notch信号通路)
Notch is a family of transmembrane proteins with repeated extracellular EGF domains and the notch (or DSL) domains.
- Cat.No. 产品名称 Information
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GC25838
RBPJ Inhibitor-1 (RIN1)
RBPJ Inhibitor-1 (RIN1) is a potent inhibitor of the transcription factor RBPJ that disrupts the interaction between NOTCH and RBPJ.
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GC64922
Rovalpituzumab
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GC64536
Notch 1 TFA
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GC64378
Valproic acid-d6
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GC50703
Yhhu 3792
Notch signaling pathway activator; enhances the self-renewal capability of neural stem cells (NSCs) via Notch signaling pathway activation in vitro and in vivo
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GC61233
RBPJ Inhibitor-1
RBPJ Inhibitor-1 (RIN1) is a potent inhibitor of the transcription factor RBPJ that disrupts the interaction between NOTCH and RBPJ.
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GC18533
ZLDI-8
ZLDI-8 是一种 Notch 激活/切割酶 ADAM-17 抑制剂,可抑制 Notch 蛋白的切割。 ZLDI-8 降低促存活/抗凋亡和上皮间质转化 (EMT) 相关蛋白的表达。 ZLDI-8 还是一种竞争性且不可逆的酪氨酸磷酸酶 (Lyp) 抑制剂,IC50 为 31.6 μM,Ki 为 26.22 μM。 ZLDI-8 抑制 MHCC97-H 细胞的生长,IC50 为 5.32 μM。
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GC50470
SAHM1
SAHM1 是一种类似于主脑样 (MAML) 的显性阴性形式的肽模拟物,可抑制典型的 Notch 转录复合物形成。
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GC38745
CB-103
An inhibitor of Notch signaling
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GC36362
Jagged-1 188-204
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GC36361
Jagged-1 (188-204) TFA
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GC36304
IMR-1A
IMR-1A, an acid metabolite of IMR-1, is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. IMR-1A exhibits anti-tumor activity.
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GC35612
Carvacrol
A monoterpene with diverse biological activities
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GC35559
Bruceine D
Bruceine D, isolated from Brucea javanica (L.) Merr. (Simaroubaceae), shows antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. Bruceine D induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway.
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GC35537
BMS-983970
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GC35535
BMS-906024
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GC34635
JI051
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GC31268
tCFA15
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GC14847
Psoralidin
A furanocoumarin with anti-cancer activity
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GC12741
IMR-1
An inhibitor of Maml1 recruitment to chromatin
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GC15896
Z-Ile-Leu-aldehyde
Z-Ile-Leu-aldehyde (Z-IL-CHO) 是一种有效的、竞争性的 γ-分泌酶和缺口肽醛抑制剂。
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GC11424
Valproic acid
A class I HDAC inhibitor
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GC10211
FLI-06
A Notch inhibitor
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GC12653
LY3039478
A Notch inhibitor
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GC15794
Valproic acid sodium salt (Sodium valproate)
A class I HDAC inhibitor
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GC13673
BMS-708163 (Avagacestat)
A potent inhibitor of γ-secretase
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GC12191
LY-411575
A γ-secretase inhibitor
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GC17671
YO-01027 (Dibenzazepine, DBZ)
An inhibitor of γ-secretase
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GC16197
RO4929097
An inhibitor of γ-secretase
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GN10797
Tangeretin
Polymethoxylated flavone
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GC12096
Semagacestat (LY450139)
A pan γ-secretase inhibitor