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PPAR(过氧化物酶体增殖剂激活受体)

The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.

  1. Cat.No. 产品名称 Information
  2. GC67866 PPARδ/γ agonist 1 sodium
  3. GC65414 2-(Tetradecylthio)acetic acid
  4. GC64873 Leriglitazone hydrochloride
  5. GC64699 Bocidelpar
  6. GC49884 Trigonelline-d3 (chloride) An internal standard for the quantification of trigonelline
  7. GC64099 AZD-9574 AZD-9574 is a novel PARP inhibitor which combines PARP1 selectivity, trapping and high CNS penetration in a single molecule.
  8. GC49521 MHY553 An agonist of PPARα
  9. GC63358 5-Aminosalicylic Acid-D3 hydrochloride
  10. GC62974 FK614
  11. GC62836 AMG131
  12. GC49087 Clofibric Acid-d4 An internal standard for the quantification of clofibric acid
  13. GC62203 Falcarindiol Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.
  14. GC61805 Cefminox sodium Cefminox Sodium (Meicelin, MT-141) is the sodium salt form of cefminox, a semi-synthetic, second-generation, beta-lactamase-stable cephalosporin with antibacterial activity.
  15. GC48782 10,13-epoxy-11-methyl-Octadecadienoic Acid A furan fatty acid
  16. GC48521 KRP 297 A dual agonist of PPARα and PPARγ
  17. GC48426 CAY10771 A dual agonist of FXR and PPARδ
  18. GC48272 ZLY032 A dual FFAR1 and PPARδ agonist
  19. GC48059 Rosiglitazone-d3 An internal standard for the quantification of rosiglitazone
  20. GC47820 Oleoyl Ethanolamide-d4 An internal standard for the quantification of oleoyl ethanolamide
  21. GC47819 Oleoyl Ethanolamide-d2 An internal standard for the quantification of oleoyl ethanolamide
  22. GC47397 Gemfibrozil-d6 An internal standard for the quantification of gemfibrozil
  23. GC47337 Fenofibrate-d6 An internal standard for the quantification of fenofibrate
  24. GC47063 CAY10767 A PPARα agonist
  25. GC46757 9(Z),11(E)-Conjugated Linoleic Acid (sodium salt) An isomer of linoleic acid
  26. GC46447 15-deoxy-δ12,14-Prostaglandin J2-d4 An internal standard for the quantification of 15-deoxy-Δ12,14-prostaglandin J2
  27. GC46365 1,1'-(Azodicarbonyl)dipiperidine A Mitsunobu reagent
  28. GC61187 Pioglitazone D4 An internal standard for the quantification of pioglitazone
  29. GC61055 Methyl oleanonate
  30. GC61043 Mesalamine impurity P
  31. GC60710 Ciprofibrate impurity A
  32. GC60675 Caulophyllogenin
  33. GC39701 Convallatoxin
  34. GC50019 GW 1929 hydrochloride A non-thiazolidinedione activator of PPARγ
  35. GC39271 (±)-Naringenin A citrus-derived flavonoid
  36. GC39191 iRucaparib-AP6
  37. GC45981 Pristanic Acid-d3

    An internal standard for the quantification of pristanic acid

  38. GC45726 Bezafibrate-d4 An internal standard for the quantification of bezafibrate
  39. GC45567 SR 1903 A modulator of RORγ and LXR receptors
  40. GC45566 SR 16832 A dual-site covalent antagonist of PPARγ
  41. GC45506 MD001 A dual agonist of PPARα and PPARγ
  42. GC37889 VCE-004.8
  43. GC37622 Seladelpar sodium salt
  44. GC36867 Pemafibrate racemate
  45. GC36146 Glabrone
  46. GC35698 Ciprofibrate D6 An internal standard for the quantification of ciprofibrate
  47. GC35518 Bilobetin A biflavonoid with diverse biological activities
  48. GC35358 Ankaflavin
  49. GC35349 Angeloylgomisin H
  50. GC35308 Alpinetin Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity.
  51. GC35281 Aleglitazar

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