PPAR(过氧化物酶体增殖剂激活受体)
The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.
- Cat.No. 产品名称 Information
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GC67866
PPARδ/γ agonist 1 sodium
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GC65414
2-(Tetradecylthio)acetic acid
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GC64873
Leriglitazone hydrochloride
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GC64699
Bocidelpar
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GC49884
Trigonelline-d3 (chloride)
An internal standard for the quantification of trigonelline
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GC64099
AZD-9574
AZD-9574 is a novel PARP inhibitor which combines PARP1 selectivity, trapping and high CNS penetration in a single molecule.
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GC49521
MHY553
An agonist of PPARα
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GC63358
5-Aminosalicylic Acid-D3 hydrochloride
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GC62974
FK614
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GC62836
AMG131
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GC49087
Clofibric Acid-d4
An internal standard for the quantification of clofibric acid
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GC62203
Falcarindiol
Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.
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GC61805
Cefminox sodium
Cefminox Sodium (Meicelin, MT-141) is the sodium salt form of cefminox, a semi-synthetic, second-generation, beta-lactamase-stable cephalosporin with antibacterial activity.
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GC48782
10,13-epoxy-11-methyl-Octadecadienoic Acid
A furan fatty acid
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GC48521
KRP 297
A dual agonist of PPARα and PPARγ
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GC48426
CAY10771
A dual agonist of FXR and PPARδ
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GC48272
ZLY032
A dual FFAR1 and PPARδ agonist
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GC48059
Rosiglitazone-d3
An internal standard for the quantification of rosiglitazone
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GC47820
Oleoyl Ethanolamide-d4
An internal standard for the quantification of oleoyl ethanolamide
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GC47819
Oleoyl Ethanolamide-d2
An internal standard for the quantification of oleoyl ethanolamide
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GC47397
Gemfibrozil-d6
An internal standard for the quantification of gemfibrozil
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GC47337
Fenofibrate-d6
An internal standard for the quantification of fenofibrate
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GC47063
CAY10767
A PPARα agonist
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GC46757
9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
An isomer of linoleic acid
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GC46447
15-deoxy-δ12,14-Prostaglandin J2-d4
An internal standard for the quantification of 15-deoxy-Δ12,14-prostaglandin J2
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GC46365
1,1'-(Azodicarbonyl)dipiperidine
A Mitsunobu reagent
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GC61187
Pioglitazone D4
An internal standard for the quantification of pioglitazone
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GC61055
Methyl oleanonate
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GC61043
Mesalamine impurity P
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GC60710
Ciprofibrate impurity A
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GC60675
Caulophyllogenin
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GC39701
Convallatoxin
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GC50019
GW 1929 hydrochloride
A non-thiazolidinedione activator of PPARγ
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GC39271
(±)-Naringenin
A citrus-
derived flavonoid -
GC39191
iRucaparib-AP6
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GC45981
Pristanic Acid-d3
An internal standard for the quantification of pristanic acid
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GC45726
Bezafibrate-d4
An internal standard for the quantification of bezafibrate
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GC45567
SR 1903
A modulator of RORγ and LXR receptors
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GC45566
SR 16832
A dual-site covalent antagonist of PPARγ
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GC45506
MD001
A dual agonist of PPARα and PPARγ
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GC37889
VCE-004.8
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GC37622
Seladelpar sodium salt
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GC36867
Pemafibrate racemate
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GC36146
Glabrone
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GC35698
Ciprofibrate D6
An internal standard for the quantification of ciprofibrate
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GC35518
Bilobetin
A biflavonoid with diverse biological activities
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GC35358
Ankaflavin
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GC35349
Angeloylgomisin H
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GC35308
Alpinetin
Alpinetin, a composition of Alpinia katsumadai Hayata, has been reported to have a number of biological properties, such as antibacterial, antitumor and other important therapeutic activities. Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata, activates activates PPAR-γ, with potent anti-inflammatory activity.
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GC35281
Aleglitazar