PPAR(过氧化物酶体增殖剂激活受体)
The peroxisome proliferator-activated receptors (PPARs), belonging to the nuclear receptor superfamily, are a group of nuclear receptor proteins that are composed of three isoforms, including PPARγ, PPARα and PPARδ, encoded by separate genes. PPARs have a modular structure characterized by the presence of two highly conserved domains, including the DNA binding domain (DBD) of two zinc fingers and the ligand binding domain (LBD) of 13 α-helices and a small 4-stranded β-sheet. PPARs are ligand-regulated transcription factors controlling gene expression by binding to specific response elements (PPREs) within promoters, where PPARs bind as heterodimers with a retinoid X receptor and interact with cofactors upon binding leading to the increasing of rate of transcription initiation.
Products for PPAR
- Cat.No. 产品名称 Information
- GC31450 Naveglitazar racemate Naveglitazarracemate是Naveglitazar的外消旋体。Naveglitazar是过氧化物酶体增殖物激活受体(PPAR)α-γ双重,γ显性激动剂,在动物模型具有降低葡萄糖潜力。
- GC31408 Indeglitazar (PPM 204) Indeglitazar (PPM 204) (PPM 204) 是一种可口服的 PPAR 泛激动剂,适用于所有三种 PPARα, PPARδ和PPARγ;。
- GC31396 Raspberry ketone (Frambione) Raspberry ketone (p-Hydroxybenzyl acetone, Frambinone, Oxyphenylon, Rheosmin, Rasketone) is a natural phenolic compound that is the primary aroma compound of red raspberries. Raspberry ketone shows cardioprotective action against isoproterenol-induced myocardial infarction in rats, and the effects may be due to its PPAR-α agonistic activity.
- GC31350 Astaxanthin Astaxanthin (β-Carotene-4,4'-dione, Trans-Astaxanthin), a xanthophyll carotenoid, is a nutrient with unique cell membrane actions and diverse clinical benefits with excellent safety and tolerability. Astaxanthin, a red dietary carotenoid isolated from Haematococcus pluvialis, is a modulator of PPARγ and a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity.
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GC31325
Saroglitazar Magnesium
Saroglitazarmagnesium是一种新型的过氧化物酶体增殖物活化受体PPAR的激动剂,具有显著PPARα活性和中度PPARγ活性,在HepG2细胞中的EC50值分别为0.65pMand3nM。
- GC31320 Lanifibranor (IVA337) A PPAR agonist
- GC30462 Pparδ agonist 1 Pparδagonist1是PPAR-δ的激动剂,EC50值为5.06nM,可用于研究与PPAR-δ相关的疾病,例如:线粒体疾病、肌肉疾病、血管疾病、脱髓鞘疾病和代谢疾病。
- GC30379 Saroglitazar A PPARα and PPARγ dual agonist
- GC19450 MA-0204 MA-0204 是一种有效的、高选择性和可口服的过氧化物酶体增殖物激活受体 δ (PPARδ) 调节剂,对人类、小鼠和大鼠 PPARδ 的 EC50 分别为 0.4 nM、7.9 nM 和 10 nM。
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GC19280
Pemafibrate
Pemafibrate (K-877) is an oral peroxisome proliferator-activated receptor (PPAR)-α agonist for the treatment of hyperlipidaemia, EC50 on Gal4hPPARα = 1 nM.
- GC19242 Seladelpar Seladelpar (MBX-8025) 是一种口服有效的(50% 作用浓度 EC50 2 nM)和特异性 PPAR-δ 激动剂。
- GC18876 CAY10599 An agonist of PPARγ
- GC18151 Elafibranor (GFT505) An agonist of PPARα and PPARδ
- GC15909 RB394 A dual modulator of sEH and PPARγ
- GC16488 SR 2595 An inverse agonist of PPARγ
- GC15085 G3335 A PPARγ antagonist III
- GC14232 SR 1824 A non-agonist PPARγ ligand
- GC10190 DG-172 (hydrochloride) An orally available PPARβ/δ inverse agonist
- GC14531 Glycerophospho-N-Oleoyl Ethanolamine Precursor of oleoyl ethanolamide
- GC12289 3-Thiatetradecanoic Acid An analog of myristic acid
- GC12760 LT175 A dual PPARα/γ ligand
- GC16301 Cetaben A non-fibrate hypolipidemic drug
- GC14595 MCC-555 A structural homolog of rosiglitazone
- GC12400 N-Octadecyl-N'-propyl-sulfamide A potent PPARα activator
- GC11732 GW 590735 A potent and selective agonist of PPARα
- GC11477 Darglitazone A PPARγ agonist
- GC14246 Muraglitazar A PPARα and PPARγ dual agonist
- GC15995 BMS 687453 A potent PPARα agonist
- GC11916 GQ-16 A PPARγ partial agonist
- GC14584 Fenofibric acid An agonist of PPARα, PPARγ, and PPARδ and an active metabolite of fenofibrate
- GC14187 GW 6471 An antagonist of PPARα
- GC10381 AUDA A potent inhibitor of soluble epoxide hydrolase
- GC16944 SR 1664 An inhibitor of Cdk5-mediated PPARγ phosphorylation
- GC15673 CP 775146 A PPARα agonist
- GC18037 Tesaglitazar A PPARα/γ agonist
- GC12252 S26948 A PPARγ agonist
- GC17824 GSK 0660 A PPARβ/δ antagonist
- GC12062 nTZDpa PPARγ partial agonist
- GC11586 SR 202 An antagonist of agonist-induced PPARγ transcriptional activity
- GC18024 GW 7647 A selective PPARα agonist
- GC16103 Oleylethanolamide An endogenous, potent agonist for PPARα
- GC13829 BADGE A PPARγ ligand that disrupts hormone-mediated cell differentiation
- GC17135 Ciglitazone A potent, selective PPARγ ligand
- GC13960 15-deoxy-Δ-12,14-Prostaglandin J2 Contains 90-95% of the trans,trans-Δ12,14 isomer
- GC17377 Clofibrate A selective PPARα agonist
- GC14543 Bezafibrate A non-selective PPAR agonist
- GC14915 Gemfibrozil A PPARα and PPARγ agonist
- GC12250 Fenofibrate A PPARα agonist
- GC16607 Mesalamine An NSAID and active metabolite of sulfasalazine, balsalazide, and olsalazine
- GC14948 Pioglitazone Pioglitazone (PIO)是一种噻唑烷二酮类抗糖尿病药物,可作为PPARγ激动剂。它对人和小鼠PPARγ的EC50分别为0.93和0.99 µM..