Autophagy(自噬)

Cat.No. 产品名称 Information

GC25651 MRT68921 HCl MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.

GC25650 MRT67307 HCl MRT67307 is a potent and dual IKKε and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibits ULK1 and ULK2 and blocks autophagy.

GC52477 Corynoxine (hydrochloride) An indole alkaloid

GC52467 Cell Death Screening Library For screening a variety of cell death pathways

GC65575 Cabazitaxel-d6

GC65540 eIF4A3-IN-2

GC65432 LV-320

GC65386 Trimetazidine-d8 dihydrochloride

GC65331 IZCZ-3

GC65318 BOLD-100

GC65307 S130

GC65297 MW-150 An inhibitor of p38α MAPK

GC65191 DC-LC3in-D5

GC65115 mTOR inhibitor-1 mTOR inhibitor-1 is a novel mTOR pathway inhibitor which can suppress cells proliferation and inducing autophagy.

GC65106 Pregnenolone-d4-1

GC65072 Niacin-13C6

GC65010 Bortezomib-d8

GC65004 Apostatin-1 Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N). Apostatin-1 inhibits bortezomib-induced apoptosis and RIPK1-dependent apoptosis (RDA) with an IC50 of about 1 μM.

GC64524 Clematichinenoside AR

GC52057 QN523 An anticancer agent

GC49815 Oleuropein aglycone A polyphenol with diverse biological activities

GC64378 Valproic acid-d6

GC64363 Lumefantrine-d9

GC64358 Olacaftor

GC64325 Ligustilide Ligustilide is the most abundant bioactive ingredient in Rhizoma Chuanxiong, a Chinese medicinal herb commonly used for the treatment of cardiovascular ailments. Solutions are best fresh-prepared.

GC64223 Sophocarpine monohydrate An alkaloid with diverse biological activities

GC64136 Desmethyl Naproxen-d3

GC64113 Lamotrigine-13C3,d3

GC64098 Isoniazid-d4

GC64076 Nortriptyline Nortriptyline hydrochloride (Desitriptyline, ELF-101, EN-7048, Desmethylamitriptyline) is the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression.

GC64070 Omeprazole-d3-1 An internal standard for the quantification of omeprazole

GC64032 Salicylic acid-d6

GC64013 ZX-29 ZX-29 is a potent and selective ALK inhibitor with an IC50s of 2.1, 1.3 and 3.9 nM for ALK, ALK L1196M and ALK G1202R mutations, respectively.

GC64003 Carvedilol-d4

GC63840 Tat-beclin 1 Tat-beclin 1 (Tat-BECN1), a peptide known to stimulate autophagy through mobilization of endogenous Beclin 1, induces autophagy in vitro and in vivo and improves clinical outcomes.

GC63827 Atropine sulfate monohydrate A non-selective muscarinic acetylcholine receptor antagonist

GC49670 Indium (III) thiosemicarbazone 5b An anticancer agent

GC63601 Trimetazidine An Analytical Reference Standard

GC63515 Hoechst 33342 A fluorescent DNA probe

GC63316 Ammonium chloride Ammonium chloride is an inorganic compound and can be used for establishing the rat model of renal calcium oxalate calculus, it is also an autophagy inhibitor.

GC62881 CA77.1 CA77.1 (CA) is a potent, brain-penetrant and orally active activator of chaperone-mediated autophagy (CMA) for the treament of Alzheimer's disease (AD).

GC62853 Aumitin

GC49341 Spermidine-d6 An internal standard for the quantification of spermidine

GC49308 Ungeremine A betaine-type alkaloid with diverse biological activities

GC49189 (E/Z)-4-hydroxy Tamoxifen-d5 An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen

GC49084 PHY34 An inhibitor of late-stage autophagy

GC49016 Dimethyl 2-ketoglutarate An esterified form of α-ketoglutarate

GC62630 TAS-117 hydrochloride

GC62626 ICCB-19 hydrochloride ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits Receptor-interacting serine/threonine-protein kinase 1 (RIPK1). ICCB-19 effectively induces autophagy.

GC62564 Mito-LND