Autophagy(自噬)
Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.
Products for Autophagy
- Cat.No. 产品名称 Information
- GC49016 Dimethyl 2-ketoglutarate An esterified form of α-ketoglutarate
- GC62630 TAS-117 hydrochloride TAS-117 hydrochloride 是一种有效、选择性、具有口服活性的别构 Akt 抑制剂 (对 Akt1、2 和 3 的 IC50 分别为 4.8、1.6 和 44 nM)。TAS-117 hydrochloride 激发抗骨髓瘤活性并增强蛋白酶体抑制诱导的致命内质网应激。TAS-117 hydrochloride 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)。
- GC62626 ICCB-19 hydrochloride ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits Receptor-interacting serine/threonine-protein kinase 1 (RIPK1). ICCB-19 effectively induces autophagy.
- GC62564 Mito-LND Mito-LND (Mito-Lonidamine) 是一种具有口服活性的且靶向线粒体的氧化磷酸化 (oxidative phosphorylation (OXPHOS)) 抑制剂。Mito-LND 抑制线粒体生物能,刺激活性氧 (reactive oxygen species) 的形成,并诱导肺癌细胞自噬细胞死亡。
- GC62528 (Rac)-Hesperetin (Rac)-Hesperetin 是Hesperetin 的外消旋体。 Hesperetin 是一种天然黄烷酮类物质,为有效的,广谱的人 UGT 抑制剂。Hesperetin 可通过激活 p38 MAPK 来诱导凋亡。
- GC62465 Idelalisib D5 Idelalisib D5 (CAL-101 D) 是 Idelalisib 的一种氘代化合物。Idelalisib 是一种口服有效的高选择性 p110δ 抑制剂。
- GC62339 mTOR inhibitor-8 mTOR inhibitor-8 是一种 mTOR 抑制剂和自噬 (autophagy) 诱导剂。mTOR inhibitor-8 通过 FKBP12 抑制 mTOR 活性,并诱导 A549 人肺癌细胞自噬。
- GC62309 AS1708727 AS1708727 是口服有效的 Foxo1 抑制剂,其对 G6Pase 和 PEPCK 的 EC50 值分别为 0.33 μM 和0.59 μM。
- GC62203 Falcarindiol Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.
- GC61865 Cearoin Cearoin 通过促进 ROS 产生和激活 ERK 来增强自噬 (autophagy) 和诱导细胞凋亡(apoptosis)。
- GC19766 Heparin sodium salt (MW 15kDa) 肝素钠盐(MW 15kDa)(Sodium heparin (MW 15kDa))是肝素的聚合物,分子量为15kDa。
- GC61809 Olanzapine D3 OlanzapineD3(LY170053D3)是Olanzapine的氘代物。Olanzapine是一种选择性单胺能拮抗剂,高亲和力结合5-羟色胺H1,5HT2A/2C,5HT3,5HT6(Ki分别为7、4、11、57和5nM),多巴胺D1-4(Ki=11-31nM),毒蕈碱M1-5(Ki=1.9-25nM)和肾上腺素α1受体(Ki=19nM)。Olanzapine是一种非典型的抗精神病剂。
- GC61669 Ethyl 3,4-dihydroxybenzoate Ethyl3,4-dihydroxybenzoate(Ethylprotocatechuate)是一种抗氧化剂,是一种在花生种子的种皮中发现的脯氨酰羟化酶(prolyl-hydroxylase)抑制剂。Ethyl3,4-dihydroxybenzoate通过激活NO合酶(NOsynthase)并产生线粒体ROS来保护心肌。Ethyl3,4-dihydroxybenzoate可诱导ESCC细胞自噬(autophagy)和凋亡(apoptosis)。Ethyl3,4-dihydroxybenzoate是胶原蛋白合成抑制剂,具有骨骼保护作用。
- GC61565 Indophagolin Indophagolin, a potent indoline-containing autophagy inhibitor with IC50 of 140 nM, antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively, also has a strong antagonistic effect on serotonin receptor 5-HT6 with IC50 of 1.0 μM.
- GC61521 Calmodulin-Dependent Protein Kinase II(290-309) acetate Calmodulin-DependentProteinKinaseII(290-309)acetate是有效的CaMK拮抗剂,抑制抑制Ca2+/钙调蛋白依赖性蛋白激酶II的IC50值为52nM。
- GC61520 Cilengitide TFA An integrin αVβ3 receptor antagonist
- GC61472 Zingiberene Zingiberene(α-Zingiberene)是一种单环倍半萜烯,是姜油的主要成分。具有神经保护潜能。Zingiberene能诱导自噬(autophagy)。具有抗癌活性。
- GC19729 Adenosine 5′-diphosphoribose sodium Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) 是一种烟酰胺腺嘌呤核苷酸 (NAD+) 代谢物。
- GC48689 SBP-7455 A dual inhibitor of ULK1 and ULK2
- GC48676 Monascuspiloin A fungal metabolite with anticancer activity
- GC48595 Chenodeoxycholic Acid MaxSpec® Standard A primary bile acid
- GC19569 Hydroquinone
- GC48124 Tamoxifen-d5 An internal standard for the quantification of tamoxifen
- GC48118 Sunitinib-d10 An internal standard for the quantification of sunitinib
- GC48052 Rilmenidine-d4 An internal standard for the quantification of rilmenidine
- GC48027 Rapamycin-d3 An internal standard for the quantification of rapamycin
- GC47735 N-acetyl Desethylchloroquine-d4 An internal standard for the quantification of N-acetyl desethylchloroquine
- GC47445 Hydroxychloroquine-d4 (sulfate) An internal standard for the quantification of hydroxychloroquine
- GC47436 HT-2 Toxin-13C22 An internal standard for the quantification of HT-2 toxin
- GC47408 Glycochenodeoxycholic Acid-d4 An internal standard for the quantification of glycochenodeoxycholic acid
- GC47303 Erlotinib-d6 (hydrochloride) An internal standard for the quantification of erlotinib
- GC47195 Desethylchloroquine-d4 An internal standard for the quantification of desethylchloroquine
- GC47194 Desethylchloroquine An active metabolite of chloroquine
- GC47193 Desethyl Hydroxychloroquine-d4 An internal standard for the quantification of desethyl hydroxychloroquine
- GC47065 CAY10773 A derivative of sorafenib
- GC46923 Bexarotene-d4 A neuropeptide with diverse biological activities
- GC46897 AUTEN-99 An inhibitor of MRMR14/Jumpy
- GC61263 Salvigenin A polyphenol flavonoid with diverse biological activities
- GC61256 Rupatadine D4 fumarate RupatadineD4fumarate(UR-12592D4fumarate)是Rupatadinefumarate的氘代标记物。RupatadineFumarate(UR-12592Fumarate)富马酸盐是PAF/H1受体双抑制剂,Ki值分别为0.55μM和0.1μM。
- GC61251 Rosuvastatin D3 RosuvastatinD3(ZD4522D3)是Rosuvastatin的一种氘代化合物。Rosuvastatin(ZD4522)是一种竞争性HMG-CoA还原酶抑制剂,IC50为11nM。Rosuvastatin有效阻断人类醚-a-go-go相关基因(hERG)电流,IC50为195nM,延迟心脏复极化,从而延长动作电位持续时间(APDs)和校正QT间期(QTc)间隔。
- GC61229 Quinacrine dihydrochloride Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.
- GC61227 Quercetin D5 QuercetinD5是Quercetin的一种氘代化合物。Quercetin是一种天然黄酮类化合物,可激活或抑制许多蛋白质的活性。Quercetin可激活SIRT1,也可抑制PI3K,抑制PI3Kγ,PI3Kδ,PI3Kβ的IC50分别为2.4μM,3.0μM,5.4μM。
- GC61183 Physalin B PhysalinB是Capegooseberry中主要的甾体活性成分之一,通过调节p53依赖的凋亡途径,诱导乳腺癌细胞周期阻滞和诱导凋亡(apoptosis)。PhysalinB抑制人结肠癌细胞泛素-蛋白酶体通路并诱导不完全自噬反应。
- GC61155 Omeprazole sodium An irreversible inhibitor of the gastric proton pump
- GC61045 Metformin D6 hydrochloride An internal standard for the quantification of metformin
- GC61003 Loperamide D6 hydrochloride LoperamideD6hydrochloride(R-18553D6hydrochloride)是Loperamidehydrochloride的氘代化合物。Loperamidehydrochloride是一种阿片受体(opioidreceptor)的激动剂,可用于腹泻的研究。
- GC60935 Indomethacin sodium hydrate A non-selective COX inhibitor
- GC60930 Imatinib D4 ImatinibD4(STI571D4)是Imatinib(STI571)的氘代物。Imatinib是一种口服生物可用的酪氨酸激酶抑制剂,可选择性抑制BCR/ABL,v-Abl,PDGFR,c-kit激酶活性。
- GC60891 GW406108X GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.
- GC60882 Glyphosate An herbicide