Autophagy(自噬)

Cat.No. 产品名称 Information

GC37677 SRT 1720 A selective, potent SIRT1 activator

GC37676 SR9011 hydrochloride A REV-ERBα/β agonist

GC37669 Soyasapogenol B Soyasapogenol B，大豆的一种成分，具有抗增殖，抗转移活性。Soyasapogenol B 触发内质网应激反应，其介导结肠直肠癌中的细胞凋亡和自噬。

GC37665 Sorafenib (D4) Sorafenib D4 (Bay 43-9006 D4) 是 Sorafenib 氘代化合物标准品。Sorafenib 是一种多激酶抑制剂，抑制 Raf-1，B-Raf 和 VEGFR-3 的 IC50 分别为6 nM，20 nM，22 nM。

GC37664 Sorafenib (D3) An internal standard for the quantification of sorafenib

GC37646 SKF-86002 An anti-inflammatory agent

GC37630 Sevelamer Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.

GC37601 SBE13 A potent Plk1 inhibitor

GC37595 SB 242235 A p38α MAPK inhibitor

GC37575 Ruxolitinib sulfate A potent, selective JAK1/JAK2 inhibitor

GC37561 Rosuvastatin D6 Sodium An internal standard for the quantification of rosuvastatin

GC37560 Rosuvastatin D6 Calcium Rosuvastatin D6钙盐是Rosuvastatin的氘代化合物标准品。

GC37559 Rosuvastatin D3 Sodium Rosuvastatin D3钠盐是Rosuvastatin氘代化合物标准品。

GC36963 Pregnenolone monosulfate Pregnenolone monosulfate 是大麻素 CB1 受体的特异性抑制剂。

GC36930 Pitavastatin D4 Pitavastatin D4是Pitavastatin氘代化合物标准品。

GC36928 Pirarubicin Hydrochloride An anthracycline antitumor antibiotic

GC36879 PF-04457845 A selective FAAH inhibitor

GC36868 Pennogenin 3-O-beta-chacotrioside Pennogenin 3-O-beta-chacotrioside, an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1, and posesses anti-colorectal cancer activity.

GC36855 Paris saponin VII Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.

GC36848 Pantoprazole sodium hydrate A proton pump inhibitor

GC36847 Pantoprazole sodium A proton pump inhibitor

GC36821 OSU-T315 OSU-T315 (ILK-IN-2) is a potent Integrin-Linked Kinase (ILK) inhibitor with IC50 of 0.6 μM. OSU-T315 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity. OSU-T315 exhibits anti-tumor activity.

GC36806 Omeprazole D3 An internal standard for the quantification of omeprazole

GC36758 Norepinephrine hydrochloride

A racemic mixture of of L-norepinephrine and D-norepinephrine

GC36736 Nicodicosapent Nicodicosapent 是一种脂肪酸烟酸共轭体，可以抑制固醇调节元件结合蛋白 (SREBP) 的活性，调节胆固醇代谢的蛋白质如 PCSK9，HMG-CoA reductase，ATP citrate lyase 和 NPC1L1 等的活性。

GC36703 N-Benzyloleamide N-Benzyloleamide 是从 Lepidium meyenii (Maca) 中分离出的一种 maccamide。N-Benzyloleamide 不可逆地抑制脂肪酸酰胺水解酶 (FAAH)。N-Benzyloleamide 影响能量代谢，显示抗氧化和抗疲劳活性。

GC36690 Nampt-IN-3 Nampt-IN-3 (Compound 35) 同时抑制烟酰胺磷酸核糖转移酶 (NAMPT) 和 HDAC，IC50 分别为 31 nM 和 55 nM。Nampt-IN-3 有效诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)，最终导致细胞死亡。

GC36671 N-Benzyllinolenamide N-?Benzyllinolenamide 是从玛卡中得到的玛卡酰胺，为脂肪酰胺水解酶 (FAAH) 抑制剂，IC50 值为 41.8 μM。

GC36646 Momelotinib Mesylate Momelotinib Mesylate (CYT387 Mesylate) 是一种 ATP 竞争性的 JAK1/JAK2 抑制剂，IC50 值分别为 11 nM/18 nM，对其选择性约是 JAK3 的 10 倍。

GC36517 LYN-1604 hydrochloride A ULK1 activator

GC36479 Loperamide hydrochloride An Analytical Reference Standard

GC36447 Licochalcone E Licochalcone E 是可从Glycyrrhiza inflate 中提取到的黄酮类化合物，通过抑制AKT 和 MAPK 的激活来抑制NF-κB 和 AP-1 的转录活性。

GC36427 Lasalocid sodium An ionophore antibiotic

GC36356 Ixazomib citrate Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively.

GC36346 Isosorbide mononitrate A nitric oxide donor with cardioprotective activity

GC36339 Isorhapontigenin Isorhapontigenin (ISOR), isolated from Belamcanda chinensis, is a derivative of stilbene. Isorhapontigenin possessed potent antioxidative activity. Isorhapontigenin suppresses interleukin-1β-induced inflammation and cartilage matrix damage in rat chondrocytes.

GC36329 Irinotecan hydrochloride A potent inhibitor of DNA topoisomerase I

GC36215 Heparin Lithium salt Heparin Lithium salt 是一种抗凝剂，可与抗凝血酶III (ATIII) 可逆地结合 (50-400 U/Kg)。

GC36163 Glycycoumarin Glycycoumarin 是一种甘草中主要的生物活性香豆素。Glycycoumarin 通过激活自噬，抑制内质网应激介导的 JNK 和 GSK-3 介导的线粒体途径，来抑制肝细胞脂性凋亡。Glycycoumarin 能直接靶向 T-LAK 细胞源蛋白激酶发挥抗肝癌活性。

GC36149 GLPG2451 GLPG2451 是一种囊性纤维化跨膜电导调节器 (CFTR) 的增强剂，有效增强低温挽救的 F508del CFTR，EC50 为 11.1 nM。

GC36136 Ginkgolide K A terpene trilactone with diverse biological activities

GC36130 Gemcitabine elaidate A prodrug form of gemcitabine

GC36063 FMK 9a FMK 9a是autophagin-1的抑制剂，在FRET和LRA试验中测定的IC50值分别为80 和73 nM。

GC36061 Fluvastatin D6 sodium An internal standard for the quantification of fluvastatin

GC36023 FAAH inhibitor 1 FAAH inhibitor 1是脂肪酸酰胺水解酶（FAAH）抑制剂，IC50为18 nM。

GC36003 Erlotinib mesylate An EGFR tyrosine kinase inhibitor

GC35998 Episilvestrol Episilvestrol 是 silvestrol 的衍生物，从 Aglaia silvestris 中分到，能够抑制 eIF4A 靶作用的转录过程。

GC35982 EN6 An activator of autophagy

GC35969 eIF4A3-IN-1 eIF4A3-IN-1 (compound 53a) 是一种选择性的真核起始因子 4A3 (eIF4A3) 抑制剂 (IC50=0.26 μM; Kd=0.043 μM)，eIF4A3-IN-1 与 eIF4A3 的非 ATP 结合位点结合，并在 10 μM 和 3 μM 时明显抑制细胞无义介导的 RNA 衰变 (NMD), 可作为进一步研究 eIF4A3、外显子连接复合体 (EJC) 和 NMD 的探针。

GC35832 Dehydrocorydaline chloride An alkaloid with diverse biological activities

Autophagy(自噬)

Products for Autophagy