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Bradykinin Receptors(缓激肽受体)

Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF.

Bradykinin (BK) has been reported to be involved in the progression of many types of cancer. Two bradykinin receptors, bradykinin B1 receptor (B1R) and bradykinin B2 receptor (B2R), are significantly expressed in all the tested colorectal cancer cells. Repression of B2R, but not B1R, attenuates the BK-mediated invasion and migration, and inhibits ERK1/2 activation and IL-6 production. Moreover, blocking of the ERK pathway decreases the BK-mediated IL-6 production. In addition, IL-6 repression suppresses the effects of BK on colorectal cancer cell invasion and migration.

Bradykinin, the enzymatic product of kallikrein-kinin system (KKS), is a major modulator of Ang II actions on blood volume, vascular reactivity and salt sensitivity.

  1. Cat.No. 产品名称 Information
  2. GC61535 Lys-[Des-Arg9]Bradykinin TFA
  3. GC50373 Retrobradykinin 逆缓激肽具有与缓激肽相反的序列。
  4. GA20221 (Hyp³)-Bradykinin (Hyp³)-缓激肽,天然存在的肽激素,是一种缓激肽受体激动剂。
  5. GC35548 Bradykinin An endogenous vasodilator
  6. GC35015 [Des-Arg9]-Bradykinin An active metabolite of bradykinin and agonist of bradykinin B1 receptors
  7. GC43888 Icatibant (acetate) A synthetic peptide antagonist of the bradykinin B2 receptor
  8. GC34042 Bradykinin 2-9 (Des-Arg1-bradykinin)
  9. GC33850 [Des-Arg9]-Bradykinin acetate An active metabolite of bradykinin and agonist of bradykinin B1 receptors
  10. GC32605 Bradykinin 1-6
  11. GC32601 Bradykinin 1-7 (Bradykinin Fragment 1-​7)
  12. GC32592 Bradykinin 1-5
  13. GC32576 Bradykinin 1-3
  14. GC31926 FR167344 free base
  15. GC19339 SSR240612 A bradykinin B1 receptor antagonist
  16. GC16820 ELN441958 ELN441958 是一种有效、中性、竞争性和选择性的缓激肽 B1 受体拮抗剂,对天然人缓激肽 B1 受体的 Ki 为 0.26 nM。
  17. GC17933 WIN 64338 hydrochloride WIN 64338 hydrochloride 是一种有效的、选择性的、非肽竞争性缓激肽 B2 受体拮抗剂。
  18. GC15188 MEN 11270 B2 bradykinin receptor antagonist
  19. GC16110 R 715 缓激肽 B1 受体拮抗剂
  20. GC11961 Sar-[D-Phe8]-des-Arg9-Bradykinin selective bradykinin B1 receptor agonist
  21. GC18038 [Phe8Ψ(CH-NH)-Arg9]-Bradykinin Selective bradykinin B2 receptor agonist
  22. GC17164 Lys-Bradykinin Endogenous bradykinin receptor agonist
  23. GC13179 R 892 bradykinin B1 receptor antagonist
  24. GC10255 Lys-[Des-Arg9]Bradykinin bradykinin B1 receptor agonist
  25. GC15587 HOE 140 HOE 140 (HOE-140) 是一种有效且特异性的缓激肽 B2 受体肽拮抗剂,IC50 和 Ki 分别为 1.07 nM 和 0.798 nM。
  26. GC16761 Bombinakinin M Potent bradykinin receptor agonist
  27. GC14629 Bombinakinin-GAP Bioactive bradykinin-related peptide

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