Search Site
  • 0
    My Cart

    Click Here to Find How Many Items You Have Added:)

qq在线咨询
Home >> Signaling Pathways >> GPCR/G protein >> Bradykinin Receptors

Bradykinin Receptors(缓激肽受体)

Bradykinin is a potent vasodilator peptide that exerts its vasodilatory action through stimulation of specific endothelial B2 receptors, thereby causing the release of prostacyclin, NO, and EDHF.

Bradykinin (BK) has been reported to be involved in the progression of many types of cancer. Two bradykinin receptors, bradykinin B1 receptor (B1R) and bradykinin B2 receptor (B2R), are significantly expressed in all the tested colorectal cancer cells. Repression of B2R, but not B1R, attenuates the BK-mediated invasion and migration, and inhibits ERK1/2 activation and IL-6 production. Moreover, blocking of the ERK pathway decreases the BK-mediated IL-6 production. In addition, IL-6 repression suppresses the effects of BK on colorectal cancer cell invasion and migration.

Bradykinin, the enzymatic product of kallikrein-kinin system (KKS), is a major modulator of Ang II actions on blood volume, vascular reactivity and salt sensitivity.

  1. Cat.No. 产品名称 Information
  2. GC69135 Fulimetibant Fulimetibant 是一种缓激肽受体 (bradykinin receptor) 拮抗剂。
  3. GC61535 Lys-[Des-Arg9]Bradykinin TFA Lys-[Des-Arg9]BradykininTFA是一种天然存在的激肽，是一种有效且高度选择性的缓激肽B1受体激动剂，对人，小鼠和兔子的B1受体的Ki值为0.12nM，1.7nM和0.23nM。Lys-[Des-Arg9]BradykininTFA对B2受体的抑制活性较低。
  4. GC50373 Retrobradykinin 逆缓激肽具有与缓激肽相反的序列。
  5. GA20221 (Hyp³)-Bradykinin (Hyp³)-缓激肽，天然存在的肽激素，是一种缓激肽受体激动剂。
  6. GC35548 Bradykinin An endogenous vasodilator
  7. GC35015 [Des-Arg9]-Bradykinin An active metabolite of bradykinin and agonist of bradykinin B1 receptors
  8. GC43888 Icatibant (acetate) A synthetic peptide antagonist of the bradykinin B2 receptor
  9. GC34042 Bradykinin 2-9 (Des-Arg1-bradykinin) 缓激肽 2-9 (Des-Arg1-bradykinin) 是一种氨基截短的缓激肽。
  10. GC33850 [Des-Arg9]-Bradykinin acetate An active metabolite of bradykinin and agonist of bradykinin B1 receptors
  11. GC32605 Bradykinin 1-6 Bradykinin(1-6)是一种氨基截短的激肽肽。Bradykinin(1-6)是由羧肽酶Y切割形成的一种稳定的Bradykinin代谢物。
  12. GC32601 Bradykinin 1-7 (Bradykinin Fragment 1-​7) 缓激肽 1-7（缓激肽片段 1-7）是一种氨基截短的缓激肽。
  13. GC32592 Bradykinin 1-5 Bradykinin(1-5)是Bradykinin的主要稳定代谢物，由血管紧张素转换酶(ACE)经蛋白水解作用形成。
  14. GC32576 Bradykinin 1-3 Bradykinin(1-3)是一个含3个氨基酸的残基肽。Bradykinin(1-3)是由脯氨酰内肽酶切割形成的一种氨基截短的激肽肽。
  15. GC31926 FR167344 free base FR167344freebase是有口服活性，非多肽的缓激肽受体B2(bradykininreceptorB2)拮抗剂，对B2有高亲和力，IC50值为65nM，对B1受体没有结合力。
  16. GC19339 SSR240612 A bradykinin B1 receptor antagonist
  17. GC16820 ELN441958 ELN441958 是一种有效、中性、竞争性和选择性的缓激肽 B1 受体拮抗剂，对天然人缓激肽 B1 受体的 Ki 为 0.26 nM。
  18. GC17933 WIN 64338 hydrochloride WIN 64338 hydrochloride 是一种有效的、选择性的、非肽竞争性缓激肽 B2 受体拮抗剂。
  19. GC15188 MEN 11270 B2 bradykinin receptor antagonist
  20. GC16110 R 715 缓激肽 B1 受体拮抗剂
  21. GC11961 Sar-[D-Phe8]-des-Arg9-Bradykinin selective bradykinin B1 receptor agonist
  22. GC18038 [Phe8Ψ(CH-NH)-Arg9]-Bradykinin Selective bradykinin B2 receptor agonist
  23. GC17164 Lys-Bradykinin Endogenous bradykinin receptor agonist
  24. GC13179 R 892 bradykinin B1 receptor antagonist
  25. GC10255 Lys-[Des-Arg9]Bradykinin bradykinin B1 receptor agonist
  26. GC15587 HOE 140 HOE 140 (HOE-140) 是一种有效且特异性的缓激肽 B2 受体肽拮抗剂，IC50 和 Ki 分别为 1.07 nM 和 0.798 nM。
  27. GC16761 Bombinakinin M Potent bradykinin receptor agonist
  28. GC14629 Bombinakinin-GAP Bioactive bradykinin-related peptide

27 Item(s)

per page

Set Descending Direction