TNF-α(肿瘤坏死因子-α)
Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.
- Cat.No. 产品名称 Information
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GC67680
BIO8898
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GC66460
UCB-5307
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GC66382
Lucatumumab
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GC66345
Golimumab
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GC65487
Certolizumab pegol
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GC65031
Belimumab
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GC64864
EJMC-1
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GC64839
Varlilumab
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GC64767
ISIS 104838
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GC63972
5,7-Dimethoxyflavanone
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GC63231
TNF-α-IN-2
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GC62451
Benpyrine
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GC62400
LEESGGGLVQPGGSMK acetate
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GC62346
UCB-9260
UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 binds TNF with Kd of 13 ?nM. UCB-9260 also inhibits NF-κB with IC50 of 202?nM after TNF stimulation.
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GC61533
UTL-5g
UTL-5g (GBL-5g) is a novel small-molecule TNF-α inhibitor which can lower hepatotoxicity, nephrotoxicity and myelotoxicity induced by Cisplatin.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
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GC48907
Metaxalone-d6
An internal standard for the quantification of metaxalone
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GC48827
Flufenamic Acid-d4
An internal standard for the quantification of flufenamic acid
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GC48292
α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)
A peptide hormone
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GC48202
Treprostinil (diethanolamine salt)
An agonist of IP2, DP2, and EP2 receptors
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GC48195
trans-trismethoxy Resveratrol-d4
An internal standard for the quantification of trans-trismethoxy resveratrol
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GC48099
SR 12460
An IKKβ NBD mimetic
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GC48098
SR 12343
An IKKβ NBD mimetic
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GC47544
Lauric Acid-13C
An internal standard for the quantification of lauric acid
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GC46862
Apigenin-d5
An internal standard for the quantification of apigenin
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GC60796
D-Trimannuronic acid
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GC60225
Licarin A
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GC39815
Semapimod tetrahydrochloride
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GC50196
Simvastatin - d6
An internal standard for the quantificaition of simvastatin
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GC39070
Negletein
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GC46015
KY 05009
A TNIK inhibitor
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GC45960
9c(i472)
A 15-LO-1 inhibitor
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GC38868
TRAF-STOP inhibitor 6877002
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GC45798
Rhein-13C4
An internal standard for the quantification of rhein
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GC45772
6(5H)-Phenanthridinone
An inhibitor of PARP1 and 2
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GC37555
Roquinimex
An immunomodulator with diverse biological activities
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GC36106
Gamma-glutamylcysteine (TFA)
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GC35523
Bioymifi
A DR5 agonist
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GC35440
AX-024
An inhibitor of the CD3ε-Nck interaction
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GC35377
Apratastat
An inhibitor of ADAM17 and MMPs
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GC35184
7,3',4'-Tri-O-methylluteolin
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GC44943
sPLA2 Inhibitor
An orally active inhibitor of sPLA2-IIA
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GC44388
NF-κB Control
A negative control peptide used with NF-κB inhibitor
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GC44097
LY303511 (hydrochloride)
An inhibitor of cell proliferation
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GC43894
IKK2 Inhibitor VI
An inhibitor of IKK2
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GC43368
D,L-1′-Acetoxychavicol Acetate
A natural exportin 1 inhibitor
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GC43190
CAY10682
A dual inhibitor of p53-Mdm2 interaction and NF-κB signaling
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GC43189
CAY10681
A dual modulator of p53-MDM2 interaction and NF-κB signaling
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GC43176
CAY10575
An IKKβ and Plk1 inhibitor
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GC43110
C8 Galactosylceramide (d18:1/8:0)
A synthetic bioactive sphingolipid
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GC42953
BMS 345541 (trifluoroacetate salt)
BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 μM).