Home >> Signaling Pathways >> Apoptosis >> TNF-α

TNF-α(肿瘤坏死因子-α)

Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.

  1. Cat.No. 产品名称 Information
  2. GC67680 BIO8898
  3. GC66460 UCB-5307
  4. GC66382 Lucatumumab
  5. GC66345 Golimumab
  6. GC65487 Certolizumab pegol
  7. GC65031 Belimumab
  8. GC64864 EJMC-1
  9. GC64839 Varlilumab
  10. GC64767 ISIS 104838
  11. GC63972 5,7-Dimethoxyflavanone
  12. GC63231 TNF-α-IN-2
  13. GC62451 Benpyrine
  14. GC62400 LEESGGGLVQPGGSMK acetate
  15. GC62346 UCB-9260 UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 binds TNF with Kd of 13 ?nM. UCB-9260 also inhibits NF-κB with IC50 of 202?nM after TNF stimulation.
  16. GC61533 UTL-5g UTL-5g (GBL-5g) is a novel small-molecule TNF-α inhibitor which can lower hepatotoxicity, nephrotoxicity and myelotoxicity induced by Cisplatin.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
  17. GC48907 Metaxalone-d6 An internal standard for the quantification of metaxalone
  18. GC48827 Flufenamic Acid-d4 An internal standard for the quantification of flufenamic acid
  19. GC48292 α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) A peptide hormone
  20. GC48202 Treprostinil (diethanolamine salt) An agonist of IP2, DP2, and EP2 receptors
  21. GC48195 trans-trismethoxy Resveratrol-d4 An internal standard for the quantification of trans-trismethoxy resveratrol
  22. GC48099 SR 12460 An IKKβ NBD mimetic
  23. GC48098 SR 12343 An IKKβ NBD mimetic
  24. GC47544 Lauric Acid-13C An internal standard for the quantification of lauric acid
  25. GC46862 Apigenin-d5 An internal standard for the quantification of apigenin
  26. GC60796 D-Trimannuronic acid
  27. GC60225 Licarin A
  28. GC39815 Semapimod tetrahydrochloride
  29. GC50196 Simvastatin - d6 An internal standard for the quantificaition of simvastatin
  30. GC39070 Negletein
  31. GC46015 KY 05009 A TNIK inhibitor
  32. GC45960 9c(i472) A 15-LO-1 inhibitor
  33. GC38868 TRAF-STOP inhibitor 6877002
  34. GC45798 Rhein-13C4 An internal standard for the quantification of rhein
  35. GC45772 6(5H)-Phenanthridinone An inhibitor of PARP1 and 2
  36. GC37555 Roquinimex An immunomodulator with diverse biological activities
  37. GC36106 Gamma-glutamylcysteine (TFA)
  38. GC35523 Bioymifi A DR5 agonist
  39. GC35440 AX-024 An inhibitor of the CD3ε-Nck interaction
  40. GC35377 Apratastat An inhibitor of ADAM17 and MMPs
  41. GC35184 7,3',4'-Tri-O-methylluteolin
  42. GC44943 sPLA2 Inhibitor An orally active inhibitor of sPLA2-IIA
  43. GC44388 NF-κB Control A negative control peptide used with NF-κB inhibitor
  44. GC44097 LY303511 (hydrochloride) An inhibitor of cell proliferation
  45. GC43894 IKK2 Inhibitor VI An inhibitor of IKK2
  46. GC43368 D,L-1′-Acetoxychavicol Acetate A natural exportin 1 inhibitor
  47. GC43190 CAY10682 A dual inhibitor of p53-Mdm2 interaction and NF-κB signaling
  48. GC43189 CAY10681 A dual modulator of p53-MDM2 interaction and NF-κB signaling
  49. GC43176 CAY10575 An IKKβ and Plk1 inhibitor
  50. GC43110 C8 Galactosylceramide (d18:1/8:0) A synthetic bioactive sphingolipid
  51. GC42953 BMS 345541 (trifluoroacetate salt) BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 μM).

Items 1 to 50 of 100 total

per page
  1. 1
  2. 2

Set Descending Direction