TNF-α(肿瘤坏死因子-α)
Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.
Products for TNF-α
- Cat.No. 产品名称 Information
- GC14976 Lenalidomide (CC-5013) An analog of thalidomide
- GN10280 Sinensetin An anti-inflammatory flavone
- GN10030 Fisetin A flavonoid with diverse biological activities
- GN10216 Shikonin A natural product with anti-inflammatory and anti-tumor activity
- GN10254 Ginsenoside Rc A saponin with diverse biological activities
- GN10151 Geraniin A tannin with diverse biological activities
- GN10727 Forsythoside B A phenylpropanoid glycoside with diverse biological activities
- GN10429 Neochlorogenic acid A phenolic compound with diverse biological activities
- GN10415 Astilbin A flavonoid with diverse biological activities
- GN10538 Ginsenoside Rh1 A steroid glycoside with diverse biological activities
- GN10217 Hypaconitine A diterpene alkaloid with diverse biological activities
- GN10055 Mulberroside A A phenol with diverse biological activities
- GN10335 Mesaconitine 新乌头碱是乌头属植物的主要活性成分。
- GC15083 Celastrol A triterpenoid antioxidant