TNF-α(肿瘤坏死因子-α)

Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.

Products for TNF-α

Cat.No. 产品名称 Information
GC35440 AX-024 An inhibitor of the CD3ε-Nck interaction
GC35377 Apratastat An inhibitor of ADAM17 and MMPs
GC35184 7,3',4'-Tri-O-methylluteolin 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) 是一种来自草药马鞭草科 (Lippia nodiflora L.) 的类黄酮，Lippia nodiflora L. 已被证明具有抗炎，解热，镇咳，抗糖尿病，抗癌和抗黑素生成特性。7,3',4'-Tri-O-methylluteolin 以浓度依赖方式明显抑制促炎细胞因子，如 TNF-α，IL-6 和 IL-1β。7,3',4'-Tri-O-methylluteolin 显著降低在转录水平的诱导型一氧化氮合酶和环加氧酶-2 的 mRNA 表达。
GC44943 sPLA2 Inhibitor An orally active inhibitor of sPLA₂-IIA
GC44388 NF-κB Control A negative control peptide used with NF-κB inhibitor
GC44097 LY303511 (hydrochloride) An inhibitor of cell proliferation
GC43894 IKK2 Inhibitor VI An inhibitor of IKK2
GC43368 D,L-1′-Acetoxychavicol Acetate A natural exportin 1 inhibitor
GC43190 CAY10682 A dual inhibitor of p53-Mdm2 interaction and NF-κB signaling
GC43189 CAY10681 A dual modulator of p53-MDM2 interaction and NF-κB signaling
GC43176 CAY10575 An IKKβ and Plk1 inhibitor
GC43110 C8 Galactosylceramide (d18:1/8:0) A synthetic bioactive sphingolipid
GC42953 BMS 345541 (trifluoroacetate salt) BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 μM).
GC42925 Berteroin A natural sulforaphane analog
GC42880 Avenanthramide-C methyl ester Inhibitor of NF-κB activation
GC41342 Terrecyclic Acid A sesquiterpene
GC40650 CAY10706 A TrxR inhibitor
GC19533 Infliximab
Infliximab (Avakine) 是一种嵌合单克隆 IgG1 抗体，可特异性结合 TNF-α。
GC34579 Etanercept
Etanercept(Enbrel)是一种肿瘤坏死因子(TNF)抑制剂，用于治疗类风湿性关节炎，强直性脊柱炎，银屑病关节炎和斑块状银屑病。
GC34513 C25-140 C25-140 is a small-molecule inhibitor of TRAF6-Ubc13 interaction. C25-140 directly binds to TRAF6, thereby blocking the interaction of TRAF6 with Ubc13, and as a consequence lowers TRAF6 activity. C25-140 impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells.
GC34214 Adalimumab (Anti-Human TNF-alpha, Human Antibody) 阿达木单抗（Adalimumab 抗人TNFα，人抗体）是治疗类风湿关节炎的主要疗法之一。
GC33934 DCVC DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine) 是三氯乙烯 (TCE) 的生物活性代谢物。
GC33826 C 87 C87是一种新型小分子TNFα抑制剂;高效抑制TNFα诱导的细胞毒性，IC50值为8.73μM。
GC33825 Taurochenodeoxycholic acid (12-Deoxycholyltaurine)
A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications
GC33337 CDC801
CDC801是一种强效的磷酸二酯酶4(PDE4)和肿瘤坏死因子-α(TNF-α)抑制剂。IC50分别为1.1μM和2.5μM。
GC33330 Cynaropicrin A sesquiterpene lactone
GC33133 SPD304 A small-molecule inhibitor of TNFα activity
GC31905 TNF-α-IN-1 TNF-α-IN-1是TNF-α抑制剂，来自专利US20030096841A1，化合物实例I-7.
GC31739 Hispidol ((Z)-Hispidol) Hispidol ((Z)-Hispidol) ((Z)-Hispidol ((Z)-Hispidol)) 是炎症性肠病的潜在治疗剂；抑制 TNF-α；诱导单核细胞与结肠上皮细胞的粘附，IC50 为 0.50 μM.
GC31692 Homoplantaginin A flavonoid glycoside with antioxidant and anti-inflammatory activities
GC30910 Eucalyptol (1,8-Cineole) Eucalyptol是5-HT3受体,钾通道,TNF-α和IL-1β的抑制剂。
GC19046 AX-024 hydrochloride An inhibitor of the CD3ε-Nck interaction
GC18796 Herbicidin A An adenine nucleoside antibiotic with herbicidal activity
GC18392 Cellocidin An antibiotic
GC17632 Maslinic Acid A biologically active triterpene
GC11659 R-7050 An antagonist of TNF-α receptor signaling
GC15573 GSK481 A selective inhibitor of RIP1
GC14500 CPI-1189 A benzamide
GC16673 N-Formyl-Met-Leu-Phe A peptide agonist of FPRs
GC16007 Methylthiouracil 甲基硫氧嘧啶是一种抗甲状腺药物。
GC13473 Lenalidomide hemihydrate An analog of thalidomide
GC10350 TIC10 isomer TIC10异构体是TIC10的异构体。
GC11167 Necrostatin 2 A potent inhibitor of necroptosis
GC12045 LY 303511 An inhibitor of cell proliferation
GC14015 Lenalidomide hydrochloride An analog of thalidomide
GC10420 Apremilast (CC-10004) An orally available PDE4 inhibitor
GC11751 QNZ (EVP4593) An inhibitor of NF-κB activation
GC17054 Thalidomide An immunomodulatory compound with diverse biological activities
GC11008 Necrostatin-1
A RIP1 kinase inhibitor
GC11697 Pomalidomide (CC-4047) An inhibitor of cereblon