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Infliximab 目录号 GC19533

单抗

规格 价格 库存 购买数量
2mg
¥3,975.00
现货
5mg
¥5,555.00
现货

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Sample solution is provided at 25 µL, 10mM.

质量管理

Quality Control & SDS

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Chemical Properties

Cas No. 170277-31-3 SDF Download SDF
别名 N/A
化学名 N/A
Canonical SMILES N/A
分子式 C6428H9912N1694O1987S46 分子量 144188.23
溶解度 N/A 储存条件 Store at -30°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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产品描述

Infliximab neutralizes the biological activity of TNF-α by binding with high affinity to the soluble (free floating in the blood) and transmembrane (located on the outer membranes of T cells and similar immune cells) forms of TNF-α, and inhibits or prevents the effective binding of TNF-α with its receptors. Infliximab has high specificity for TNF-α, and does not neutralize TNF beta. Infliximab prevents disease in transgenic mice (a special type of mice biologically engineered to produce a human form of TNF-α and which are used to test the results of these drugs that might be expected in humans).

References:
[1].Promising biological therapies for ulcerative colitis: A review of the literature.
Akiho H, et al. World J Gastrointest Pathophysiol. 2015 Nov 15;6(4):219-27. PMID: 26600980.
[2].Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent.
Keane J, et al. N Engl J Med. 2001 Oct 11;345(15):1098-104. PMID: 11596589.