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Ciprostene (calcium salt) Sale

(Synonyms: Ciprostene calcium, U61431F) 目录号 : GC43270

A stable analog of PGI2

Ciprostene (calcium salt) Chemical Structure

Cas No.:81703-55-1

规格 价格 库存 购买数量
1mg
¥2,125.00
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5mg
¥9,559.00
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10mg
¥16,994.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 µg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 µg/kg/min and 60 ng/ml, respectively.

Chemical Properties

Cas No. 81703-55-1 SDF
别名 Ciprostene calcium, U61431F
Canonical SMILES CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@]2(C)[C@@H]1C/C(C2)=C/CCCC([O-])=O.CCCCC[C@H](O)/C=C\[C@H]3[C@H](O)C[C@@]4(C)[C@@H]3C/C(C4)=C\CCCC([O-])=O.[Ca+2]
分子式 [C22H35O4]2•Ca2+ 分子量 767.1
溶解度 DMF: > 25 mg/ml,DMSO: > 16.8 mg/ml,ethanol: > 34 mg/ml,PBS pH 7.2: > 0.29 µ g/ml 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 1.3036 mL 6.5181 mL 13.0361 mL
5 mM 0.2607 mL 1.3036 mL 2.6072 mL
10 mM 0.1304 mL 0.6518 mL 1.3036 mL
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Research Update

Beneficial effects of acute intravenous ibuprofen on neurologic recovery of head-injured mice: comparison of cyclooxygenase inhibition with inhibition of thromboxane A2 synthetase or 5-lipoxygenase

Cent Nerv Syst Trauma 1985 Summer;2(2):75-83.PMID:3938345DOI:10.1089/cns.1985.2.75

The ability of the cyclooxygenase inhibitor ibuprofen to affect early neurologic recovery following a moderately severe concussive head injury was studied in male CF-1 mice. Each mouse received a 900 g-cm (50 g weight dropped 18 cm) head injury, followed within 5 minutes with a single IV dose of ibuprofen (sodium salt; 1, 3, 10, or 30 mg/kg). At 1 hour postinjury, their neurologic status was assessed using a grip test. Drug administration and neurologic evaluation were carried out blindly. A dose-related improvement in recovery was observed, with a 10 mg/kg IV dose causing a 122% increase in the mean grip test score compared to 0.9% saline treatment (p less than 0.01 by one-way ANOVA). In addition, there was a significant decrease in the number of mice in the 10 mg/kg ibuprofen group that fell off the grip test string in 0-5 seconds (i.e., that were severely impaired). In comparison, neither the selective thromboxane A2 synthetase inhibitor furegrelate sodium, the stable epoprostenol (PGI2) analog Ciprostene calcium, nor the selective 5-lipoxygenase inhibitor piriprost potassium caused any therapeutic effect. The highest dose of the TXA2 synthetase inhibitor (30 mg/kg IV) actually had a statistically significant detrimental action that appeared to be due to an increase in posttraumatic cerebral hemorrhage. The possible mechanisms of the beneficial effect of ibuprofen in acute head injury are discussed in relation to an attenuation of the synthesis of vasoactive arachidonic acid metabolites (e.g., prostaglandin F2 alpha, thromboxane A2) and oxygen-free radical-induced lipid peroxidation.