Home>>Signaling Pathways>> Ox Stress Reagents>> Antioxidants>>Rhein-13C4

Rhein-13C4 Sale

(Synonyms: 1,8-二羟基-3-羧基蒽醌) 目录号 : GC45798

An internal standard for the quantification of rhein

Rhein-13C4 Chemical Structure

Cas No.:1189928-10-6

规格 价格 库存 购买数量

Customer Review

Based on customer reviews.

电话:400-920-5774 Email: sales@glpbio.cn

Sample solution is provided at 25 µL, 10mM.


Quality Control & SDS

View current batch:


Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically increasing TNF-α, IL-1β, and HMBG1 expression.2 Rhein shows efficacy against pancreatic fibrosis, chronic pancreatitis, and hyperglycemia-induced pancreatic β-cell apoptosis.3,4 It also inhibits angiogenesis of breast cancer cells under normoxic and hypoxic conditions.5

|1. Domagala, F., Martin, G., Bogdanowicz, P., et al. Inhibition of interleukin-1β-induced activation of MEK/ERK pathway and DNA binding of NF-κB and AP-1: Potential mechanism for Diacerein effects in osteoarthritis. Biorheology 43(3-4), 577-587 (2006).|2. Gao, Y., Chen, X., Fang, L., et al. Rhein exerts pro- and anti-inflammatory actions by targeting IKKβ inhibition in LPS-activated macrophages. Free Radic. Biol. Med. 72, 104-112 (2014).|3. Tsang, S.W., Zhang, H., Lin, C., et al. Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitis. PLoS One 8(12), 1-15 (2013).|4. Sayre, L.M., Larson, D.L., Takemori, A.E., et al. Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different μ receptor subtypes in different tissues. Journal of Medicinal Chemistry 27(10), 1325-1335 (1984).|5. Fernand, V.E., Losso, J.N., Traux, R.E., et al. Rhein inhibits angiogenesis and the viability of hormone-dependent and -independent cancer cells under normoxic or hypoxic conditions in vitro. Chem. Biol. Interact. 192(3), 220-232 (2011).

Chemical Properties

Cas No. 1189928-10-6 SDF
别名 1,8-二羟基-3-羧基蒽醌
Canonical SMILES O=C1C2=C([13CH]=C([13C](O)=O)[13CH]=[13C]2O)C(C3=CC=CC(O)=C31)=O
分子式 C11[13C4]H8O6 分子量 288.2
溶解度 Soluble in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。


1 mg 5 mg 10 mg
1 mM 3.4698 mL 17.3491 mL 34.6981 mL
5 mM 0.694 mL 3.4698 mL 6.9396 mL
10 mM 0.347 mL 1.7349 mL 3.4698 mL
  • 摩尔浓度计算器

  • 稀释计算器

  • 分子量计算器

*在配置溶液时,请务必参考产品标签上、MSDS / COA(可在Glpbio的产品页面获得)批次特异的分子量使用本工具。


动物体内配方计算器 (澄清溶液)

给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
% DMSO % % Tween 80 % saline