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IKK2 Inhibitor VI

(Synonyms: 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide) 目录号 : GC43894

An inhibitor of IKK2

IKK2 Inhibitor VI Chemical Structure

Cas No.:354811-10-2

规格 价格 库存 购买数量
500μg
¥857.00
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1mg
¥1,542.00
现货
5mg
¥6,766.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM). [1] It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.[2][3]

Reference:
[1]. Baxter, A., Brough, S., Cooper, A., et al. Hit-to-lead studies: The discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors. Bioorganic & Medicinal Chemistry Letters 14, 2817-2822 (2004).
[2]. McNamara, L.A., Ganesh, J.A., and Collins, K.L. Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation. Journal of Virology 86(17), 9337-9350 (2012).
[3]. Punj, V., Matta, H., and Chaudhary, P.M. A computational profiling of changes in gene expression and transcription factors induced by vFLIP K13 in primary effusion lymphoma. PLoS One 7(5), 1-15 (2012).

Chemical Properties

Cas No. 354811-10-2 SDF
别名 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide
化学名 2-[(aminocarbonyl)amino]-5-phenyl-3-thiophenecarboxamide
Canonical SMILES O=C(N)NC1=C(C(N)=O)C=C(C2=CC=CC=C2)S1
分子式 C12H11N3O2S 分子量 261.3
溶解度 2mg/mL in ethanol, 30mg/mL in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.827 mL 19.1351 mL 38.2702 mL
5 mM 0.7654 mL 3.827 mL 7.654 mL
10 mM 0.3827 mL 1.9135 mL 3.827 mL
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