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STAT (signal transducer and activator of transcription) are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumour surveillance.

  1. Cat.No. 产品名称 Information
  2. GC25899 SC-1 SC-1 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7), a Sorafenib analogue and potently inhibits the phosphorylation of STAT3, induces cell apoptosis through SHP-1 dependent STAT3 inactivation.
  3. GC67958 HP590
  4. GC67779 STX-0119
  5. GC67706 LY5
  6. GC52293 STAT3 Inhibitor 4m A STAT3 inhibitor
  7. GC65344 STAT5-IN-2 STAT5-IN-2 inhibits the growth of acute and chronic myeloid leukemia cells and the phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation, with minimal effects on bone marrow stromal cells that play vital functions in the microenvironment of hematopoietic and leukemic cells.
  8. GC65020 Danvatirsen
  9. GC64891 YM-341619
  10. GC63204 Stafib-2
  11. GC63203 Stafia-1-dipivaloyloxymethyl ester
  12. GC49139 CAY10784 A STAT3 inhibitor
  13. GC62559 Stafia-1 Stafia-1 is the first STAT5a inhibitor that inhibits STAT5a (IC50=22.2?μM, Ki=10.9?μM) with at least 9‐fold selectivity over STAT5b and higher selectivity against other STAT family members.
  14. GC62272 AC-4-130
  15. GC62254 Stafib-1
  16. GC61807 (E/Z)-AG490
  17. GC61627 Ochromycinone
  18. GC61574 AS1810722
  19. GC61524 SC-43 An SHP-1 activator
  20. GC48839 Nifuroxazide-d4 An internal standard for the quantification of nifuroxazide
  21. GC47061 CAY10763 A dual inhibitor of IDO1 and STAT3 activation
  22. GC46503 2-(1,8-Naphthyridin-2-yl)phenol An enhancer of STAT1 activity
  23. GC60586 Angoline hydrochloride
  24. GC60585 Angoline
  25. GC50343 HJC 0416 hydrochloride HJC 0416 hydrochloride 是一种有效的口服活性 STAT3 抑制剂,具有比 Stattic 更强的抗癌特性。 HJC 0416 hydrochloride 是一种用于乳腺癌研究的有前途的抗癌剂。
  26. GC39081 Reticuline
  27. GC39022 Tetramethylcurcumin Tetramethylcurcumin (FLLL31), a small-molecule signal transducer and activator of transcription 3 (STAT3) inhibitor derived from curcumin, binds selectively to Janus kinase 2 and the STAT3 Src homology-2 domain, which serve crucial roles in STAT3 dimerization and signal transduction.
  28. GC38737 AS2863619 free base A dual inhibitor of Cdk8 and Cdk19
  29. GC38736 AS2863619 A dual inhibitor of Cdk8 and Cdk19
  30. GC45756 Pimozide-d4 An internal standard for the quantification of pimozide
  31. GC38386 Golotimod hydrochloride
  32. GC38044 Fraxinellone A liminoid degradant with diverse biological activities
  33. GC37689 STAT3-IN-3
  34. GC37688 STAT3-IN-1 STAT3-IN-1 (compound 7d) is an excellent, selective and orally active inhibitor of STAT3 with IC50 of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 induces apoptosis of tumor cells.
  35. GC36175 Golotimod (TFA)
  36. GC36174 Golotimod
  37. GC36016 Eupalinolide K
  38. GC35720 Colivelin TFA A potent STAT3 activator and neuroprotective agent
  39. GC35715 CMD178 TFA
  40. GC35651 Cenisertib
  41. GC35554 Brevilin A A sesquiterpene lactone with anticancer activity
  42. GC35466 Balsalazide sodium hydrate A prodrug form of 5-ASA
  43. GC35395 Arnicolide D A sesquiterpene lactone with anticancer activity
  44. GC44880 SD 1029 A JAK2 inhibitor
  45. GC44400 Niclosamide (ethanolamine salt)

    An anthelmintic mitochondrial uncoupler

  46. GC44227 MM-206 A STAT3 inhibitor
  47. GC44213 ML115 A cell-permeable STAT3 activator
  48. GC43406 Delphinidin (chloride) Natural vasorelaxant and inhibitor of EGFRs and HATs
  49. GC42974 Brassinin An anticancer phytoalexin
  50. GC40715 Ascochlorin An isoprenoid antibiotic and antiviral
  51. GC34742 Protosappanin A

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