STAT(信号转导及转录激活蛋白)

STAT (signal transducer and activator of transcription) are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumour surveillance.

Cat.No. 产品名称 Information
GC25899 SC-1 SC-1 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7), a Sorafenib analogue and potently inhibits the phosphorylation of STAT3, induces cell apoptosis through SHP-1 dependent STAT3 inactivation.
GC67958 HP590
GC67779 STX-0119
GC67706 LY5
GC52293 STAT3 Inhibitor 4m A STAT3 inhibitor
GC65344 STAT5-IN-2 STAT5-IN-2 inhibits the growth of acute and chronic myeloid leukemia cells and the phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation, with minimal effects on bone marrow stromal cells that play vital functions in the microenvironment of hematopoietic and leukemic cells.
GC65020 Danvatirsen
GC64891 YM-341619
GC63204 Stafib-2
GC63203 Stafia-1-dipivaloyloxymethyl ester
GC49139 CAY10784 A STAT3 inhibitor
GC62559 Stafia-1 Stafia-1 is the first STAT5a inhibitor that inhibits STAT5a (IC50=22.2?μM, Ki=10.9?μM) with at least 9‐fold selectivity over STAT5b and higher selectivity against other STAT family members.
GC62272 AC-4-130
GC62254 Stafib-1
GC61807 (E/Z)-AG490
GC61627 Ochromycinone
GC61574 AS1810722
GC61524 SC-43 An SHP-1 activator
GC48839 Nifuroxazide-d4 An internal standard for the quantification of nifuroxazide
GC47061 CAY10763 A dual inhibitor of IDO1 and STAT3 activation
GC46503 2-(1,8-Naphthyridin-2-yl)phenol An enhancer of STAT1 activity
GC60586 Angoline hydrochloride
GC60585 Angoline
GC50343 HJC 0416 hydrochloride HJC 0416 hydrochloride 是一种有效的口服活性 STAT3 抑制剂，具有比 Stattic 更强的抗癌特性。 HJC 0416 hydrochloride 是一种用于乳腺癌研究的有前途的抗癌剂。
GC39081 Reticuline
GC39022 Tetramethylcurcumin Tetramethylcurcumin (FLLL31), a small-molecule signal transducer and activator of transcription 3 (STAT3) inhibitor derived from curcumin, binds selectively to Janus kinase 2 and the STAT3 Src homology-2 domain, which serve crucial roles in STAT3 dimerization and signal transduction.
GC38737 AS2863619 free base A dual inhibitor of Cdk8 and Cdk19
GC38736 AS2863619 A dual inhibitor of Cdk8 and Cdk19
GC45756 Pimozide-d4 An internal standard for the quantification of pimozide
GC38386 Golotimod hydrochloride
GC38044 Fraxinellone A liminoid degradant with diverse biological activities
GC37689 STAT3-IN-3
GC37688 STAT3-IN-1 STAT3-IN-1 (compound 7d) is an excellent, selective and orally active inhibitor of STAT3 with IC50 of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 induces apoptosis of tumor cells.
GC36175 Golotimod (TFA)
GC36174 Golotimod
GC36016 Eupalinolide K
GC35720 Colivelin TFA A potent STAT3 activator and neuroprotective agent
GC35715 CMD178 TFA
GC35651 Cenisertib
GC35554 Brevilin A A sesquiterpene lactone with anticancer activity
GC35466 Balsalazide sodium hydrate A prodrug form of 5-ASA
GC35395 Arnicolide D A sesquiterpene lactone with anticancer activity
GC44880 SD 1029 A JAK2 inhibitor
GC44400 Niclosamide (ethanolamine salt)
An anthelmintic mitochondrial uncoupler
GC44227 MM-206 A STAT3 inhibitor
GC44213 ML115 A cell-permeable STAT3 activator
GC43406 Delphinidin (chloride) Natural vasorelaxant and inhibitor of EGFRs and HATs
GC42974 Brassinin An anticancer phytoalexin
GC40715 Ascochlorin An isoprenoid antibiotic and antiviral
GC34742 Protosappanin A