STAT(信号转导及转录激活蛋白)
STAT (signal transducer and activator of transcription) are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumour surveillance.
- Cat.No. 产品名称 Information
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GC25899
SC-1
SC-1 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7), a Sorafenib analogue and potently inhibits the phosphorylation of STAT3, induces cell apoptosis through SHP-1 dependent STAT3 inactivation.
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GC67958
HP590
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GC67779
STX-0119
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GC67706
LY5
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GC52293
STAT3 Inhibitor 4m
A STAT3 inhibitor
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GC65344
STAT5-IN-2
STAT5-IN-2 inhibits the growth of acute and chronic myeloid leukemia cells and the phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation, with minimal effects on bone marrow stromal cells that play vital functions in the microenvironment of hematopoietic and leukemic cells.
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GC65020
Danvatirsen
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GC64891
YM-341619
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GC63204
Stafib-2
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GC63203
Stafia-1-dipivaloyloxymethyl ester
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GC49139
CAY10784
A STAT3 inhibitor
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GC62559
Stafia-1
Stafia-1 is the first STAT5a inhibitor that inhibits STAT5a (IC50=22.2?μM, Ki=10.9?μM) with at least 9‐fold selectivity over STAT5b and higher selectivity against other STAT family members.
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GC62272
AC-4-130
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GC62254
Stafib-1
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GC61807
(E/Z)-AG490
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GC61627
Ochromycinone
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GC61574
AS1810722
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GC61524
SC-43
An SHP-1 activator
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GC48839
Nifuroxazide-d4
An internal standard for the quantification of nifuroxazide
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GC47061
CAY10763
A dual inhibitor of IDO1 and STAT3 activation
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GC46503
2-(1,8-Naphthyridin-2-yl)phenol
An enhancer of STAT1 activity
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GC60586
Angoline hydrochloride
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GC60585
Angoline
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GC50343
HJC 0416 hydrochloride
HJC 0416 hydrochloride 是一种有效的口服活性 STAT3 抑制剂,具有比 Stattic 更强的抗癌特性。 HJC 0416 hydrochloride 是一种用于乳腺癌研究的有前途的抗癌剂。
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GC39081
Reticuline
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GC39022
Tetramethylcurcumin
Tetramethylcurcumin (FLLL31), a small-molecule signal transducer and activator of transcription 3 (STAT3) inhibitor derived from curcumin, binds selectively to Janus kinase 2 and the STAT3 Src homology-2 domain, which serve crucial roles in STAT3 dimerization and signal transduction.
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GC38737
AS2863619 free base
A dual inhibitor of Cdk8 and Cdk19
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GC38736
AS2863619
A dual inhibitor of Cdk8 and Cdk19
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GC45756
Pimozide-d4
An internal standard for the quantification of pimozide
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GC38386
Golotimod hydrochloride
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GC38044
Fraxinellone
A liminoid degradant with diverse biological activities
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GC37689
STAT3-IN-3
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GC37688
STAT3-IN-1
STAT3-IN-1 (compound 7d) is an excellent, selective and orally active inhibitor of STAT3 with IC50 of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 induces apoptosis of tumor cells.
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GC36175
Golotimod (TFA)
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GC36174
Golotimod
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GC36016
Eupalinolide K
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GC35720
Colivelin TFA
A potent STAT3 activator and neuroprotective agent
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GC35715
CMD178 TFA
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GC35651
Cenisertib
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GC35554
Brevilin A
A sesquiterpene lactone with anticancer activity
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GC35466
Balsalazide sodium hydrate
A prodrug form of 5-ASA
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GC35395
Arnicolide D
A sesquiterpene lactone with anticancer activity
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GC44880
SD 1029
A JAK2 inhibitor
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GC44400
Niclosamide (ethanolamine salt)
An anthelmintic mitochondrial uncoupler
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GC44227
MM-206
A STAT3 inhibitor
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GC44213
ML115
A cell-permeable STAT3 activator
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GC43406
Delphinidin (chloride)
Natural vasorelaxant and inhibitor of EGFRs and HATs
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GC42974
Brassinin
An anticancer phytoalexin
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GC40715
Ascochlorin
An isoprenoid antibiotic and antiviral
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GC34742
Protosappanin A