IAP(凋亡抑制蛋白)
Inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that suppress apoptosis by binding to and inhibiting caspases 3, 7 and/or 9. Members of IAP family are characterized by a novel baculoviral IAP repeat (BIR) domain (approximate 70 amino acids) in which a conserved cysteine and histidine residues (Cx2Cx6Wx3Dx5Hx6C) represents a novel zinc-binding fold. However, not all proteins with BIR domain qualify to be an IAP family member. The ability to suppress apoptosis is required as well. So far, eight members of human IAP family have been identified, which are divided into three classes, including class I (XIAP, cIAP1, cIAP2, ILP2 and MLIAP), class II (NAIP) and class III (SURVIVIN and BRUCE).
- Cat.No. 产品名称 Information
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GC64980
MV1
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GC63870
SBP-0636457
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GC63709
SM-433 hydrochloride
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GC63290
Xevinapant hydrochloride
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GC63195
SM-433
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GC63194
SM-1295
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GC62640
APG-1387
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GC50465
A 410099.1
High affinity XIAP antagonist; active in vivo
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GC38545
Polygalacin D
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GC37649
SM-164 Hydrochloride
A cell-permeable Smac mimetic
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GC32803
ASTX660
A non-peptidomimetic inhibitor of IAP protein-peptide interactions
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GC32781
CUDC-427 (GDC-0917)
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GC19257
MX69
An inhibitor of the MDM2 protein and XIAP RNA interaction
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GC19050
AZD5582
A Smac mimetic and IAP inhibitor
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GC17448
AT-406 (SM-406)
A Smac mimetic and IAP antagonist
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GC16479
UC 112
UC 112 是一种新型强效 IAP(凋亡抑制剂)抑制剂;有效抑制两种人黑色素瘤(A375 和 M14)和两种人前列腺(PC-3 和 DU145)癌细胞系的细胞生长(IC50\u003d0.7-3.4 uM)。
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GC17167
SM-164
A cell-permeable Smac mimetic
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GC12333
BV6
A bivalent Smac mimetic and IAP antagonist
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GC13163
Embelin
A benzoquinone with diverse biological activities
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GC14402
Triptolide
A diterpenoid triepoxide with diverse biological activities
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GC14291
LCL161
A Smac mimetic and inhibitor of IAP family proteins
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GC14451
GDC-0152
An inhibitor of IAPs
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GC13107
YM155
A small molecule survivin suppressant
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GC12426
Birinapant (TL32711)
An antagonist of cIAP1, cIAP2, and XIAP