Home >> Signaling Pathways >> Apoptosis >> IAP


Inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that suppress apoptosis by binding to and inhibiting caspases 3, 7 and/or 9. Members of IAP family are characterized by a novel baculoviral IAP repeat (BIR) domain (approximate 70 amino acids) in which a conserved cysteine and histidine residues (Cx2Cx6Wx3Dx5Hx6C) represents a novel zinc-binding fold. However, not all proteins with BIR domain qualify to be an IAP family member. The ability to suppress apoptosis is required as well. So far, eight members of human IAP family have been identified, which are divided into three classes, including class I (XIAP, cIAP1, cIAP2, ILP2 and MLIAP), class II (NAIP) and class III (SURVIVIN and BRUCE).

  1. Cat.No. 产品名称 Information
  2. GC64980 MV1
  3. GC63870 SBP-0636457
  4. GC63709 SM-433 hydrochloride
  5. GC63290 Xevinapant hydrochloride
  6. GC63195 SM-433
  7. GC63194 SM-1295
  8. GC62640 APG-1387
  9. GC50465 A 410099.1 High affinity XIAP antagonist; active in vivo
  10. GC38545 Polygalacin D
  11. GC37649 SM-164 Hydrochloride A cell-permeable Smac mimetic
  12. GC32803 ASTX660 A non-peptidomimetic inhibitor of IAP protein-peptide interactions
  13. GC32781 CUDC-427 (GDC-0917)
  14. GC19257 MX69 An inhibitor of the MDM2 protein and XIAP RNA interaction
  15. GC19050 AZD5582 A Smac mimetic and IAP inhibitor
  16. GC17448 AT-406 (SM-406) A Smac mimetic and IAP antagonist
  17. GC16479 UC 112 UC 112 是一种新型强效 IAP(凋亡抑制剂)抑制剂;有效抑制两种人黑色素瘤(A375 和 M14)和两种人前列腺(PC-3 和 DU145)癌细胞系的细胞生长(IC50\u003d0.7-3.4 uM)。
  18. GC17167 SM-164 A cell-permeable Smac mimetic
  19. GC12333 BV6 A bivalent Smac mimetic and IAP antagonist
  20. GC13163 Embelin A benzoquinone with diverse biological activities
  21. GC14402 Triptolide A diterpenoid triepoxide with diverse biological activities
  22. GC14291 LCL161 A Smac mimetic and inhibitor of IAP family proteins
  23. GC14451 GDC-0152 An inhibitor of IAPs
  24. GC13107 YM155 A small molecule survivin suppressant
  25. GC12426 Birinapant (TL32711) An antagonist of cIAP1, cIAP2, and XIAP

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