Search results for: 'Peptide'

类别: Aminopeptidase ACE Calpains Cathepsin Gamma Secretase MMP Thrombin Other Proteases Endogenous Metabolite Mitochondrial Metabolism PAI-1 Ser/Thr Protease Caspase Bax Bcl-2 Family IAP TNF-α Other Apoptosis PD-1/PD-L1 interaction Pyroptosis Histone Acetyltransferases Histone Demethylases Histone Methyltransferase HIF Protein Ser/Thr Phosphatases Citrullination Histones/Histone Peptides PPAR Neuronal Metabolism P450 Others Bone Growth & Remodeling Carbohydrate Metabolism Cofactors & Vitamins Dyslipidemias Metabolic Syndrome Necrosis Nutrient Sensing Reproductive Biology Sterol Biosynthesis PKA p38 JNK cAMP Broad Spectrum Protein Kinase Inhibitor EGFR Insulin Receptor Src Trk ATM/ATR CDK DNA/RNA Synthesis Casein Kinase Akt AMPK GSK-3 PI3K S6 Kinase Antibiotic HCV HIV Antifungal Bacterial Parasite SARS-CoV Coronaviruses Dengue Entry/Fusion Inhibitors Yellow Fever COVID-19 Antiviral Microtubule/Tubulin Dynamin ECM & Adhesion Molecules Cytoskeleton & Motor Proteins Endomembrane System & Vesicular Trafficking Proteolysis Autophagy Proteasome STAT PKC Integrin PAR1 Neuropeptide FF/AF Receptors Formyl Peptide Receptors 5-HT Receptor Adrenergic Receptor Apelin Receptor Angiotensin Receptor Bombesin Receptors Bradykinin Receptors Calcitonin and Related Receptors Cannabinoid Receptor CaSR CCK1 Receptors CCR Chemokine Receptors CRF2 Receptors CXCR Endothelin Receptor ETB Receptors Galanin Receptors Ghrelin Receptors GIP Receptor Glucagon Receptor Melanin-concentrating Hormone Receptors Melanocortin (MC) Receptors Motilin Receptor Non-selective CRF Neurotensin Receptors NOP Receptor NPY Receptors Orphan 7-TM Receptors OX Receptor Oxytocin Receptors Peptide Receptors Protease-Activated Receptors Secretin Receptors Somatostatin Receptor Vasopressin Receptor Ras Urotensin-II Receptor VIP Receptors Neuromedin U Receptors mAChR Neurokinin Receptor Notch Wnt/β-catenin Cancer stem cell YAP AMPAR Calcium Channel Pannexin-1 Potassium Channel TRP Channel Kainate Receptors Na+/K+ ATPase iGluR Cancer Biology Peptides Ras-like GTPases Tumor Microenvironment Cell Migration & Metastasis GnRH Opioid Receptor Thyroid hormone Receptor TRH Glucocorticoids & Mineralocorticoids AChR Alzheimer Amyloid β CGRP DAPK Gap Junction GluR Histamine Receptor Neuroscience Peptides Nicotinic Receptor Substance P/NK1 Receptor CaMK Behavioral Neuroscience Neuroendocrinology Neuroprotection Ophthalmology Pain Research Parkinson Prion Diabetes NAFLD & NASH Obesity Peptide Inhibitors and Substrate Other Signal Transduction Papain TLR NF-κB Interleukin Related Complement System IFNAR NO Synthase NOD-like Receptor (NLR) STING Reactive Oxygen Species Apoptosis Glutathione Adaptive Immunity Allergy Arthritis Autoimmunity Gastric Disease Innate Immunity Pulmonary Diseases PSMA Acute Phase Reactants Arrhythmia Atherosclerosis Chronic Kidney Disease Coagulation & Hemostasis Diabetic Nephropathy Endothelium Erythrocytes & Hemoglobin Heart Failure Hypertension Hypotension Lipoproteins Myocardial Contractility Myocardial Hypertrophy Myocardial Infarction Serum Proteins Smooth Muscle Cells Stroke Vasoconstriction Thrombosis Vasodilation ADC Cytotoxin ADC Linker Drug-Linker Conjugates for ADC PROTAC Antioxidants Carbohydrate Oxidation Lipid Peroxidation Pro-Oxidant Activity Adenylate cyclase AT Receptors Cell Penetrating Peptide Cytokine Enzyme Substrates / Activators Fluorescent Probes Glycoprotein Guanylate Cyclase Guanylyl Cyclase MDR multidrug resistance Myosin Natriuretic Peptide Receptors Nitric Oxide Renin Tachykinin Transcription Factors Cyclase Toxicology Antiparasitics Toxins Peptide Coupling Reagents Amino Acids and Derivatives N-Protecting Reagents Other Reagents Other Resin and Derivatives Natural Products Screening Library Cyanine Dyes Affinity Probes Enzyme Substrates Fluorescence Biochemical Assay Reagents B type Natriuretic Peptide Transferase Insulin Macrophage Migration Inhibitory Factor GHRP GLP Glucagon Peptide Hormones Other Natural Proteins Other Superoxide Dismutase SARS Leukotrienes Lipid-Based Drug Delivery Prostaglandins Neuropeptides Tag Peptides Amyloid β protein Inhibitors and Substrates Peptide Epitopes Peptides for Drug Delivery Food-Borne Illnesses MRSA Pneumonia STDs Tuberculosis Candidiasis Leishmaniasis Quorum Sensing Hepatitis

Cat.No. 产品名称 Information
GA20927 Boc-Cys(Z-aminoethyl)-OH A protected derivative of the naturally occuring Lys analog δ-thialysine or thiosine, which can be incorporated into peptides as Lys mimetic.
GA20924 Boc-Cys(NPys)-OH Npys allows site-directed disulfide bond formation, as it is cleaved by thiols. Galande and Spatola obtained disulfide heterodimers of peptides via coupling Boc-Cys(NPys)-OH together with Fmoc-Cys(Mmt)-OH (B-2540) to MBHA-resin followed by Mmt removal with 1% TFA in dichloromethane. Mourier et al. used BCNP for the identification of T-cell epitopes in Cys and/or Cyt-containing proteins.
GA20913 Boc-cis-4-fluoro-Pro-OH
(2S,4S)-N-Boc-顺式-4-氟-L-脯氨酸
4-Fluoroprolines (all isomers) have been incorporated in collagen models and mimics. They are building blocks for engineering the secondary structure or for shifting the cis/trans equilibrium of a peptide. Additionally, the F-atom may serve as a probe (¹?F-NMR) for conformational studies.
GA20896 Boc-AOAc-OH
叔丁氧羰基氨氧基乙酸
Protected aminooxyacetic acid derivative for the incorporation of an N-terminal O-alkylhydroxylamine moiety, which is used in the chemoselective ligation of unprotected peptide fragments, for the conjugation to lipids and glycosides, and for the introduction of labels by oxime formation. Peptides containing AOAc may be cleaved selectively at the N-O bond with Zn/AcOH. See also the 12-aminooxydodecanoic acid derivative A-4720.
GA20887 Boc-Ala-D-Glu-NH₂ Building block for adjuvant peptides as romurtide.
GA20873 Boc-4-cyano-Phe-OH
Boc-L-4-氰基苯丙氨酸
Derivative for introducing p-cyanophenylalanine during Boc-SPPS. This Phe derivative may serve as a selectively excitable fluorophore or as an IR probe in peptides and for obtaining FRET substrates.
GA20868 Boc-3,4-dehydro-Pro-OH
Boc-3,4-脱氢-L-脯氨酸
This dehydro-amino acid has been incorporated into biologically active peptides such as, e.g., oxytocin, bradykinin, Arg-vasopressin, or angiotensin I-converting enzyme inhibitors.
GA20859 Biotinyl-εAhx-SCC1 (263-268)-2,4,6-trimethylbenzoyloxy-methylketone (S. cerevisiae) Yeast separase inhibitor, representing an acyloxymethyl ketone (AMK) derivative of budding yeast SCC1 cleavage recognition peptide (SVEQGR), coupled to a biotin moiety (Bio).
GA20833 Biotinyl-Gly-Gly-OH Building block for introducing biotin with a polar spacer moiety or for synthesizing biotinylated Gly-Gly-containing peptides.
GA20807 Big Endothelin-1 (1-38), human
大内皮素-1 (1-38)，人
A peptide precursor of endothelin-1
GA20806 Benzhydrylamine resin (200-400 mesh, 0.60-0.90 mmol/g) . HCl For the synthesis of C-terminally amidated peptides. The peptide-resin bond of BHA resin is stable to trifluoroacetic acid but is cleaved by hydrogen fluoride. In most cases, scavengers have to be added.
GA20805 BAM-3200 3200 Dalton opioid peptide from porcine adrenal medulla with kappa-opioid receptor agonistic properties.
GA20781 Asn-Ala-Intercellular Adhesion Molecule 1 (1-21) (human) Asn-Ala-ICAM 1 (1-21) inhibits virus replication in HIV-1 infected HTLV-1 transformed cells (MT-2 cells). The peptide induces up to 70% inhibition of reverse transcriptase activity, up to 60% reduction of soluble virus antigen production, and inhibition of syncytium formation.
GA20779 AQEE-30 (mouse, rat) AQEE-30 (VGF588-617) is a Pro-VGF-derived peptide that increases synaptic charge in hippocampal neurons, induces penile erection when injected into the paraventricular nucleus of male rats and evokes thermal hyperalgesia when injected intrathecally into naÏve adult mice.
GA20778 APL1β28
淀粉样蛋白APL1Β28
A highly sensitive biomarker for the production of Aβ 1-42 derived from the βAPP-like protein APLP1. The peptide is generated by the same proteolytic mechanism as Aβ42. Non-amyloidogenic APL1β28 can be detected in the CSF and its levels correlate with Aβ42 production. Its ratio to total APL1β (APL1β25, APL1β27, and APL1β28) is significantly increased in familial and sporadic cases of AD.
GA20764 Angiotensin II Antipeptide The sequence of this "anti-angiotensin II" peptide has been deduced from the antisense mRNA complementary to the human angiotensin II mRNA. The resulting octapeptide shows 50% sequence homology with angiotensin II. It acts, however, as an antagonist of different physiological actions of angiotensin II, such as uterine contractions or hypertensive responses in the rat.
GA20757 Anantin (linear sequence) Anantin, GFIGWGNDIFGHYSGDF, the linear form of the cyclic peptide isolated from streptomyces, acts as an ANP receptor antagonist.
GA20748 Amyloid β-Protein (3-42) The N-terminally truncated Aβ42 may be formed in increased amounts as AD progresses. Aβ 3-42 is the precursor of the Pyr-peptide. (Pyr³)-Aβ 3-42 positive plaques are resistant to age-dependent degradation likely due to their high stability and propensity to aggregate.
GA20744 Amyloid β-Protein (2-42) Aβ 2-42 could be a biomarker for differentiating AD from other degenerative dementias, such as frontotemporal dementias (FTD). The peptide promotes phagocytosis by macrophages.
GA20742 Amyloid β-Protein (17-40) Cleavage of APP by alpha- and gamma-secretase (i.e. the non-amyloidogenic pathway) yields p3 peptide, a mix of Aβ 17-40 and Aβ 17-42. p3 is a major constituent of diffuse plaques observed in AD brains and pre-amyloid plaques in people affected by Down syndrome.
GA20738 Amyloid β-Protein (1-6) Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice.
GA20722 Amyloid β-Protein (1-14) The N-terminal Aβ fragments Aβ1-14, Aβ1-15 (H-6368), and Aβ1-16 (H-2958) are elevated in cell media and in CSF in response to γ-secretase inhibitor treatment. The presence of these small peptides is consistent with a catabolic amyloid precursor protein cleavage pathway by β- followed by α-secretase. It has been shown that Aβ1-14, Aβ1-15, and Aβ1-16 increase dose-dependently in response to γ-secretase inhibitor treatment while Aβ1-42 levels are unchanged.
GA20718 Amyloid β/A4 Protein Precursor₇₇₀ (667-676)
Β-基质分泌酶Ⅲ
The peptide substrate APP (667-676), SEVKMDAEFR, corresponds to the wild-type amyloid precursor protein (APP) β-secretase cleavage site. SEVKMDAEFR has been used for assaying β-secretase activity.
GA20716 Amyloid P Component (27-38) amide A wide variety of cells attach to the surface of polystyrene plastic dishes coated with this peptide, which corresponds to a fragment of the amyloid P component, a glycoprotein found in all types of amyloid deposits.
GA20715 Amyloid Dan Protein (1-34) (reduced) Amyloid peptide that is associated with dementia.
GA20710 Amylin (8-37) (human)
糊精(8-370)(人)
A peptide fragment of amylin
GA20707 Amylin (1-13) (human) A peptide fragment of amylin
GA20705 AMCA-Glu-Glu-Lys-Pro-Ile-Ser-Phe-Phe-Arg-Leu-Gly-Lys(biotinyl)-NH₂ Specific substrate for cathepsin D (Km = 53 µM, kcat = 7.28 s?¹, kcat/Km = 0.14 µM?¹s?¹) with a single cathepsin cleavage site between the two Phe residues. It is flanked by an N-terminal AMCA-fluorophore (7-amino-4-methylcoumarin-3-acetic acid) and a C-terminal biotin moiety. After enzymatic hydrolysis the biotin-conjugated cleavage product and undigested substrate AMCA-EEKPISFFRLGK(Biotinyl)-amide can be removed with streptavidin-coated magnetic beads. The remaining fluorescent peptide in solution represents the amount of digested substrate. The versatility of this cathepsin D 'digest and pull down assay' is applicable for routine assays.
GA20696 AF-2 AF-2, KHEYLRF-amide, was isolated from a head extract of the nematode, Ascaris suum. The peptide produced multiple effects on muscle tension, markedly increasing the tension change associated with changes in muscle membrane potential. It had mainly inhibitory effects on Helix central neurones due to an increase in potassium conductance. KHEYLRF-amide has also been detected in Caenorhabditis elegans
GA20693 Adrenomedullin 5 (primate) Adrenomedullin 5 (AM5) stimulates central and peripheral cardiovascular actions in mammals. The peptide induced dose-dependent decreases in arterial pressure without affecting the heart rate, when injected intravenously. When injected into the cerebral ventricle, ADM5 increased arterial pressure and heart rate.
GA20687 Adipokinetic Hormone II (Locusta migratoria)
Lom-AKH-II
Lom-AKH II, a peptide hormone from the corpora cardiaca of the locust Locusta migratoria, is an important regulator of energy metabolism. It stimulates the mobilization of lipids from the fat body and enables long term flight.
GA20685 Adipokinetic Hormone (Apis mellifera ligustica, Bombyx mori, Heliothis zea, Manduca sexta) AKH, a peptide hormone which stimulates synthesis of 1,2-diacyl-sn-glycerols in the Manduca sexta fat body.
GA20683 Ac-α-benzyl-4,6-O-benzylidene-muramic acid
N-乙酰基-1-O-(苯基甲基)-4,6-O-(苯基亚甲基)-ALPHA-胞壁酸
Protected MurNAc derivative for the synthesis of acetyl-muramic acid peptides. For MurNAc see Q-1015.
GA20663 Ac-Trp-NHMe NATMA and NATA (E-1225) served as peptide model for studying hydration and solution dynamics of peptides and proteins.
GA20660 Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)
乙酰基-色氨酰-谷氨酰-组氨酰-天冬氨醛
Ac-WEHD-CHO, a very potent reversible inhibitor of caspase-1 (ICE). It bears the optimal tetrapeptide recognition motif for this enzyme. With a Ki of 56 pM it belongs to the most potent reversible, peptide-based inhibitors described for any protease. For caspase-8 a Ki of 21.1 nM has been reported.
GA20651 ACTH (1-16)
D-葡萄糖二酸单钾盐
A peptide fragment of ACTH
GA20636 Ac-Phe-NHMe
(ALPHAS)-ALPHA-(乙酰氨基)-N-甲基-苯丙酰胺
NAPMA serves as model for phenylalanine-containing peptides e.g. in photophysical studies.
GA20622 Ac-muramyl-Ala-D-Glu(Lys(stearoyl)-OH)-NH₂
罗莫肽,Muroctasin
The investigation of the adjuvant activity of this muramyl peptide on humoral and cellular immune responses showed that it augments the mitogenic responses of splenic lymphocytes to phytohemagglutinin and lipopolysaccharide and the formation of antibodies to sheep erythrocytes in mice. In addition, it potentiated polyclonal B cell activation in vivo and in vitro.
GA20596 Ac-Leu-NHMe
(2S)-2-(乙酰氨基)-N,4-二甲基-戊酰胺
NALMA and the more hydrophilic NAGMA (E-1060) served as peptide models for studying hydration and solution dynamics of peptides and proteins.
GA20588 Ac-Ile-Tyr-Gly-Glu-Phe-NH₂ Ac-IYGEF-amide, excellent small peptide substrate for the protein tyrosine kinase pp60c-src (Km= 368 µM and Vmax= 1.02 µmol min?¹ mg?¹).
GA20581 Ac-Ile-Glu-Thr-Asp-aldehyde (pseudo acid)
乙酰基-异亮氨酰-谷氨酰-苏氨酰-天冬氨醛
The peptide aldehyde Ac-IETD-CHO corresponds to one of the cleavage sites of the inactive 32 kD caspase-3 precursor (amino acids 172-175). In a concentration range of 0.5 µM, Ac-IETD-CHO.blocked the formation of the p17 subunit and concomitantly induced the accumulation of the 32 kD precursor.
GA20576 Ac-His(1-Trt)-OH
N-乙酰基-N'-三苯甲基-L-组氨酸
Ac-His(Trt) has been used as building block for obtaining peptide mimetics.
GA20573 Ac-Gly-NHMe NAGMA and the more hydrophobic NALMA (E-1110) served as peptide models for studying hydration and solution dynamics of peptides and proteins.
GA20572 Ac-Gly-Lys-OMe
α-N-Acetylglycyl-L-Lysine
A peptide urokinase substrate
GA20568 Ac-Gly-Ala-Val-Ile-Leu-Arg-Arg-NH₂ The cone-shaped amphiphilic peptide Ac-GAVILRR-amide consisting of a hydrophobic tail and a large cationic head group forms donut-like aggregates.
GA20567 Ac-Gly-Ala-Lys-AMC Ac-GAK-AMC, control peptide for protease-coupled histone deacetylase (HDAC) assay with Ac-Gly-Ala-Lys(Ac)-AMC (I-1975).
GA20560 Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH₂ Ac-ED(edans)KPILFFRLGK(dabcyl)E-amide, a sensitive fluorescent (FRET) peptide substrate for cathepsin D. This enzyme can degrade extracellular matrix components and may facilitate the spread of tumor cells. High levels of active cathepsin D were found within senile plaques in brains of Alzheimer's patients.
GA20538 Acetyl-Heme-Binding Protein 1 (1-21) (human) F2L is an acetylated peptide corresponding to an N-terminal fragment of the human heme-binding protein. Ac-MLGMIKNSLFGSVETWPWQVL acts specifically through the FPR-like receptor (FPRL) 2 promoting calcium mobilization and chemotaxis in dendritic cells and monocytes. In neutrophils, F2L inhibited FPR and FPRL1-mediated signaling.
GA20536 Acetylcholine Receptor α₁ (129-145) (human, bovine, rat, mouse) This fragment of a conserved sequence in nicotinic acetylcholine receptor activates T helper lymphocytes and induces the production of autoantibodies that cause electrophysiologic signs of experimental autoimmune myasthenia gravis. EIIVTHFPFDEQNCSMK may be useful in the development of a peptide-based antigen-specific immunotherapy of myasthenia gravis.
GA20534 Acetyl-Amyloid β-Protein (15-20) amide Incubation of Ac-QKLVFF-NH? with the amyloid β-protein (1-40) inhibited polymerization of the amyloid β-protein (1-40) into amyloid fibrils. The peptide is thought to block the polymerization sites.

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