Search results for: 'Peptide'

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Cat.No. 产品名称 Information
GA21515 Fmoc-Arg(Me)(Pbf)-OH Nω-Methylation is a widespread post-translational modification of Arg-containing proteins. Arg(Me) can be conveniently introduced during the Fmoc-SPPS of model peptides using this derivative.
GA21513 Fmoc-amino-PEG2-ethylamino-Suc-OH
N-(FMOC-8-氨基-3-2,6-二氧杂辛基)琥珀酰胺酸
Fmoc-Ebes, short PEG spacer, which can be incorporated into peptides during SPPS.
GA21496 Fmoc-8-aminooctanoic acid
N-Fmoc-8-氨基辛酸
Aoc, a flexible hydrophobic spacer, can also be incorporated in a peptide chain as an equivalent of a tripeptide.
GA21482 Fmoc-4-(neopentyloxysulfonyl)-Abu-OH Orthogonally protected derivative of homocysteic acid. As a Glu substitute, or for introducing a highly acidic moiety, it can be incorporated into various peptide effectors, such as receptor ligands and enzyme inhibitors. The neopentyl sulfonate can be cleaved with HF/m-cresol or by slow hydrolysis in 0.1% TFA in water/acetonitrile. This cysteic acid homolog occurs in nature; homocysteic acid, generated from plasma homocysteine, can damage endothelial tissue.
GA21472 Fmoc-(Hmb)Gly-OH
FMOC-甘氨酸-(HMB)-NCA
Incorporation of HmbGly during Fmoc-SPPS prevents the aggregation of the growing peptide. Hmb is removed during the final TFA cleavage, which can be prevented by O-acetylation. Please see also our Hmb- and Dmb-dipeptides.
GA21471 Fmoc-(Dmb)Leu-OH Derivative for the Fmoc-SPPS of backbone-protected peptides. Introduction of Dmb at appropriate positions prevents aggregation of the growing peptide chain. Please see also our Dmb-dipeptides.
GA21470 Fmoc-(Dmb)Gly-OH
FMOC-N-(2,4-二甲氧基苄基)-GLY-OH
Derivative for the Fmoc-SPPS of backbone-protected peptides. Introduction of Dmb at appropriate positions prevents aggregation and aspartimide formation. Please see also our Dmb-dipeptides.
GA21469 Fmoc-(Dmb)Ala-OH
N-[(2,4-二甲氧基苯基)甲基]-N-[芴甲氧羰基]-L-丙氨酸
Derivative for the Fmoc-SPPS of backbone-protected peptides. Introduction of Dmb at appropriate positions prevents aggregation of the growing peptide chain. Conroy et al. could stabilize the aspartimide-prone Asp(OAll or ODmab)-Ala motif by incorporating DmbAla. Please see also our Dmb-dipeptides.
GA21468 Fluorogenic Human CMV Protease Substrate The FRET substrate Dabcyl-RGVVNASSRLA-Edans has been synthesized to develop a fluorescence-based assay of human cytomegalovirus proteinase. It is cleaved specifically at the Ala-Ser bond thereby liberating the C-terminal peptide-EDANS fragment from the proximity quenching effect of the DABCYL group. This represents the first fluorescence-based assay of the herpes virus proteases and permits the characterization of potential inhibitors. Cleavage yields the N-terminal fragment H-2442.
GA21463 FITC-εAhx-Antennapedia Homeobox (43-58) amide FITC-LC-Antp Homeobox (43-58) amide can be used to translocate covalently attached peptides through biological membranes. The fluorescence label is useful for fluorescence-activated cell sorting (FACS) analysis and fluorescence microscope studies.
GA21453 FGF basic (119-126) (human, mouse, rabbit, rat) FGF sequences as KRTGQYKL block binding of basic FGF to its high affinity receptor. They also inhibit basal and basic FGF-induced proliferation of vascular endothelial cells at submicromolar peptide concentrations.
GA21432 Exendin-4 (3-39) Potent glucagon-like peptide 1 (GLP-1) receptor antagonist.
GA21424 ent-Amyloid β-Protein (1-42) All-D Aβ (1-42) exhibits similar properites as the all-L Aβ. The peptide forms ion channels in lipid bilayers.
GA21412 EAK16-II A self-assembling peptide forming a stable β-sheet structure, which may be used as carrier or matrix for cell culture.
GA21397 Dolastatin 15
DLS 15
A peptide with anticancer activity
GA21395 Dnp-Pro-TNF-α (71-82) amide (human) The sequence of the chromophoric peptide substrate Dinitrophenyl-SPLAQAVRSSSR-amide corresponds to human Pro-TNF-α (71-82) and can be used in the detection of new Pro-TNF-α-processing enzymes, with the cleavage site Ala??-Val??.
GA21393 Dnp-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg-NH₂ The FRET peptide Dnp-PLGLWAr-amide is an efficient substrate for interstitial/vertebrate collagenase (MMP-1), stromelysin (MMP-3), and especially for the gelatinases (MMP-2 and MMP-9) and the punctuated metalloproteinase (MMP-7).
GA21390 Dnp-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-OH The FRET peptide Dnp-RPLALWRS is the best fluorogenic substrate developed for matrilysin (also called punctuated metalloproteinase 1, PUMP-1 or MMP-7) thus far. In addition to good kinetic parameters (kcat/Km = 1.9 . 10? M?¹s?¹), it showed good solubility in assay buffer.
GA21389 Dnp-(Leu⁴²¹)-Collagen Type VIII α1 Chain (419-426) amide (human, mouse)
Highly sensitive and selective substrate for collagenase-3 (MMP-13) with a kcat/Km value of 4.22 · 10⁶ M⁻¹s⁻¹ (pH = 7.5, T = 37 °C). The kcat/Km value of human collagenase-3 for this synthetic peptide is 1344-, 11-, and 820-fold better than that of related MMPs stromelysin-1 (MMP-3), gelatinase B (MMP-9), and collagenase-1 (MMP-1), respectively.
GA21381 Diphenyldiazomethane resin (200-400 mesh, 0.7-1.3 mmol/g) Diphenyldiazomethane was used industrially for producing benzhydryl esters (diphenylmethyl esters) of β-lactam antibiotics. This "polymeric diphenyldiazomethane" readily reacts with carboxylic acids, e.g. Fmoc-amino acids, which need not to be activated. Products can be cleaved from this very acid-sensitive resin derivative with 1-5 % TFA in dichloromethane. Fmoc-α-amino alcohols can be anchored to PDDM in the presence of BF? etherate. As the resulting benzhydryl ethers can be cleaved with 1% TFA/DCM, fully protected peptide alcohols can be obtained.
GA21379 Dicarboxidine . 2 HCl Chromogen developed as a safe substitute for conventional benzidine type reagents. For detection of N-Boc-protected amino acids and peptides by TLC. Substrate for peroxidases as horse radish peroxidase.
GA21374 Deltorphin Deltorphin, YmFHLMD-amide, a peptide first isolated from skin extracts of the South American frog Phyllomedusa sauvagei, corresponds to the predicted prodermorphin heptapepeptide. Deltorphin acts as a highly potent and fully selective agonist for the δ-opioid receptor.
GA21368 Dde-Lys(Fmoc)-OH The amino-protecting group Dde is orthogonal to both Fmoc and Boc protection and finds increasing application in the synthesis of modified peptides assembled by Fmoc-tBu solid-phase methodologies. Dde can be cleaved by 2 % hydrazine in DMF.
GA21327 Cyclo(-Gly-His) Cyclo(His-Gly) inhibited the growth of MCF-7 cancer cells in vitro and showed antithrombotic effects. Cyclo-(His-Gly), which is related to anorexigenic peptide, was shown to inhibit release of catecholamine and norepinephrine in vitro significantly. The diketopiperazine could play a role in the hypothalamic modulation of appetite suppressant circuitry.
GA21324 Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro-Ala)
环-(-GLY-ARG-GLY-ASP-SER-PRO-ALA)
It has been demonstrated that the RGD-containing peptide, c(GRGDSPA), inhibited the binding of fibronectin to stimulated platelets with IC??= 0.223 µM. c(GRGDSPA) also blocked thrombin-induced platelet aggregation with IC??= 32 µM, but was less potent than native fibronectin in this respect.
GA21323 Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro) c(GRGDSP) is a cyclic RGD peptide. It stimulates constriction in rat afferent arteriole. It has been used for the targeted delivery of cisplatin. It could be shown, that c(RGDSP) inhibits the adhesion of mouse B16 melanoma cells onto fibronectin-coated wells.
GA21318 Cyclo(-D-Tyr-Arg-Gly-Asp-Cys(carboxymethyl)-OH) sulfoxide This sulfur-bridged cyclic RGD peptide is a potent inhibitor of the binding of glycoprotein IIb/IIIa to fibrinogen with an IC?? of 1.5 nM. Furthermore, it is a highly potent inhibitor of fibrinogen-mediated platelet aggregation (IC?? = 0.15 µM). Its antithrombotic activity in vivo may render this compound useful in the treatment of arterial thromboembolic diseases.
GA21317 Cyclo(-D-Trp-Tyr) Hsieh et al. tested peptide nanotubes obtained from cyclo-(D-Trp-Tyr) as oral gene delivery carriers in nude mice.
GA21305 Cyclo(-Arg-Gly-Asp-D-Tyr-Lys(Tide Fluor™ 7WS)) Cyclic RGD peptide labeled with a fluorophor absorbing at 749 nm and emitting at 775 nm.
GA21304 Cyclo(-Arg-Gly-Asp-D-Phe-Glu) c(RGDfE) is a cyclic RGD peptide, that has has been used as integrin ligand for radiolabeling, on gold nanoparticles and for the delivery of nanomedicine. Its negative control c(RADfE) is available as well (article number: 4099641).
GA21302 Cyclo(-Arg-Ala-Asp-D-Tyr-Lys) Control peptide for c(RGDyK)
GA21301 Cyclo(-Arg-Ala-Asp-D-Phe-Val) c(RADfV) was used as control peptide in the search for RGD analogs which are suitable to block angiogenesis. In contrast to H-2574, it had no effect on the growth of new blood vessels.
GA21288 Crotalicidin
抗菌肽CROTALICIDIN
Potent antimicrobial peptide with low cytotoxicity produced by the venom glands of Crotalus durissus terrificus.
GA21287 CRAMP-18 (mouse)
抗菌肽CRAMP-18
CRAMP-18 (mouse) corresponds to the functional region of the antibacterial peptide CRAMP. It displayed potent antibacterial activity against several bacteria with no hemolytic activity (minimal inhibitory concentration: 12.5-50 µM).
GA21281 Corazonin
黑化诱导神经肽
Corazonin is a cardioaccelerating peptide, which has been isolated from the corpus cardiacum of the American cockroach, Periplaneta americana. It is the most potent insect cardioactive neuropeptide.
GA21279 Copeptin (human)
和肽素
和肽素是一种由 39 个氨基酸组成的肽，主要产生于下丘脑的室旁神经元和视上核。
GA21276 Collagen Type II Fragment The collagen II fragment PTGPLGPKGQTGELGA-Hyp-GNKGEQGPK, a peptide analog of an antigenic determinant of type II collagen, prevents the onset of collagen-induced arthritis in vivo.
GA21272 Chorionic Gonadotropin-β (109-145) (human) Antisera raised to this 37-residue peptide from the hCG-β subunit very effectively neutralized the biological activity of hCG in vivo.
GA21262 Chemotactic Domain of Elastin Repeating peptide in elastin. VGVAPG stimulated human skin fibroblast proliferation and was chemotactic for fibroblasts and monocytes. The palmitoylated form is marketed as a cosmetic ingredient.
GA21255 Cecropin A (1-8)-Melittin (1-18) amide For this synthetic cecropin A-melittin hybrid peptide a leishmanicidal activity has been described.
GA21243 Caloxin 2A1 A peptide plasma membrane Ca²⁺/Mg²⁺-ATPase inhibitor
GA21238 Calcitonin (9-32) (free acid) (human) hCT(9-32) is a human calcitonin (hCT)-derived cell-penetrating peptide that has been shown totranslocate the plasma membrane of mammalian cells.
GA21234 C3a (72-77) (human) Anaphylatoxic peptide; induces generation of thromboxane B? from guinea pig peritoneal macrophages.
GA21221 Bz-Nle-Lys-Arg-Arg-AMC
Benzoyl-Nle-Lys-Arg-Arg-AMC, Benzoyl-Nle-Lys-Arg-Arg-7-amino-4-methylcoumarin, Bz-Nle-Lys-Arg-Arg-AMC
Bz-Nle-Lys-Arg-Arg-AMC 是黄热病病毒 (YFV) 非结构 3 (NS3)、登革热病毒 (DV) NS2B/3 丝氨酸蛋白酶和寨卡病毒的荧光四肽底物(ZIKV) NS2B/NS3 丝氨酸蛋白酶。
GA21191 Bromoacetyl resin (200-400 mesh) Enables an efficient, non-acidolytic method for the selective cleavage of phenacyl ester of Boc-amino acids and -peptides linked to a polystyrene resin by the use of trimethyltin hydroxide.
GA21139 Boc-Thionoser(Bzl)-1-(6-nitro)benzotriazolide
(S)-[2-(6-硝基-1H-苯并三唑-1-基)-1-[(苄氧基)甲基]-2-硫酮乙基]氨基甲酸叔丁酯
Building block for the synthesis of thionopeptides and peptides containing thiazolidine rings.
GA21101 Boc-Pen(Trt)-OH
N-[叔丁氧羰基]-3-[(三苯基甲基)硫基]-L-缬氨酸
Coupling of peptide thioesters to N-terminal penicillamine (introduced as Boc-Pen(Trt)) followed by desulfuration yielding valine broadens the scope of Native Chemical Ligation.
GA21059 Boc-Lys(Boc)-Pro-OH A dipeptide building block for branched peptides and dendrimers.
GA21058 Boc-Lys(Boc)-Gly-OH A dipeptide building block for branched peptides, MAPs, and dendrimers.
GA21046 Boc-Leu-Leu-OH
BOC-亮氨酰-亮氨酸
A peptide building block

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