Search results for: 'Peptide'

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Cat.No. 产品名称 Information
GA22011 H-Ala-Leu-Pro-Met-His-Ile-Arg-OH The lactokinin ALPMHIR is an angiotensin-converting enzyme (ACE) inhibitory peptide, which corresponds to a sequence released by tryptic digestion from the milk protein β-lactoglobulin. It might be useful in the treatment of hypertension although its ACE inhibitory activity is about a 100 times lower than that of the antihypertensive drug captopril.
GA21996 H-Ala-D-Glu(Lys-D-Ala-D-Ala-OH)-OH A murein peptide sequence. Substrate for DD-carboxypeptidase (muramoylpentapeptide carboxypeptidase, D-alanine carboxypeptidase).
GA21959 H-Aib-OBzl . HCl
2-甲基丙氨酸苄酯盐酸盐
Building block for the solution synthesis of Aib-containing peptides, e.g. peptaibols. Coupling to this sterically demanding amino acid derivative allows to assess the efficiency of coupling reagents and protocols.
GA21946 H-4-Cyano-Phe-OH
L-4-氰基苯丙氨酸
Key intermediate for the synthesis of amidines, which can be used as arginine mimetics. McMurray obtained p-Tetrazolylphenylalanine by 1,3-dipolar cycloaddition with trimethyltin azide. Additionally, p-Cyanophenylalanine may serve as well as a IR- or Raman-probe in peptides and recombinant proteins. As a fluorophore, it has been used in combination with Trp in FRET substrates.
GA21945 H-4,5-Dehydro-Leu-OH
(S)-甲基烯丙基甘氨酸
Precursor amino acid for tritium-labeled L-leucine. Specifically labeled bioactive peptides such as oxytocin can be conveniently synthesized by using this compound.
GA21921 Granuliberin-R Granuliberin-R is a mast cell degranulating peptide, originally isolated from the skin of the frog Rana rugosa.
GA21918 Glycoprotein Hormone α (32-46) amide The FSH, TSH, LH, and hCG are glycoprotein hormones sharing a common α subunit. Residues 32-46 of this α subunit have been identified as a receptor binding domain. This peptide fragment inhibited FSH and LH/hCG binding to their respective calf testis membrane receptors with IC?? of 36 µM and 54 µM, respectively.
GA21917 Gluten Exorphin A5 The sequence of this opioid peptide was found at 15 sites in the primary structure of the high molecular weight glutenin. Gluten exorphin A5 is highly specific for δ-receptors and displays opioid activity in the MVD assay. The N-terminal Gly increases its activity - thus the structure-activity relationships of gluten exorphins A are quite different from those of the endogenous opioid peptides.
GA21908 GLP-2 (1-34) (human)
人胰高血糖素样肽2
A synthetic form of the peptide GLP-2
GA21903 Gliadorphin-7
Prolamin (43-49), α/β-Gliadin (43-49), GD-7, Gluteomorphin

Gliadorphin-7, YPQPQPF, is an opioid peptide which is formed during digestion of the gliadin component of the gluten protein. Elevated concentrations of gliadinoorphin-7 due to insufficient proteolysis has been associated with autism, schizophrenia, and celiac disease. See also H-3858.
GA21887 Galanin (1-13)-Neuropeptide Y (25-36) amide The chimeric peptide M32 is a high affinity galanin receptor antagonist (IC??= 0.1 nM in rat hypothalamus membranes and Kd= 0.01 nM in rat spinal cord membranes). M32 is also recognized by neuropeptide Y receptors (IC??= 0.25 µM in rat cerebral cortex membranes).
GA21885 FSL-1-FLAG The lipopeptide FSL-1, synthesized on the basis of the N-terminal structure of a M. salivarium lipoprotein, is capable of inducing the cell surface expression of ICAM-1 in human gingival fibroblasts. It furthermore revealed an activity to induce production of monocyte chemoattractant protein 1, interleukin-6 (IL-6), and IL-8. FSL-1 also activated macrophages to produce tumor necrosis factor alpha. Overall, results by Okusawa and coworkers suggest that the diacylglyceryl and the peptide portions of FSL-1 are indispensable for the expression of biological activities and for the recognition by Toll-like receptors 2 and 6. Furthermore, the same authors conclude that the recognition of FSL-1 by Toll-like receptors 2 and 6 apparently is hydrophobic.
GA21878 For-Met-Leu-pNA fML-pNA, chromogenic substrate for a continuous spectrophotometric assay for peptide deformylase, see also L-2055.
GA21877 For-Met-Leu-Phe-Phe-OH
N-甲酰-间-亮氨酸-丙氨酸-丙氨酸
A potent chemotactic peptide.
GA21869 Fmoc-γ-azido-Abu-OH
(S)-2-(((9H-芴-9-基)甲氧基)羰基氨基)-4-叠氮丁酸
Protected derivative of L-azidohomoalanine (Aha), a Met isostere. This building block for 'click chemistry' additionally creates a specific cleavage site in peptides, Aha-containing sequences can be cleaved under mild conditions in the presence of phosphines or dithiols via formation of homoserine lactone.
GA21855 Fmoc-β-(2,2-dimethyl-4H-benzo[1,3]dioxin-6-yl)-Ala-OH
(S)-2-(FMOC--氨基)-3-(2,2-二甲基-4H-苯并[1,3]二氧杂环己烯-6-基)丙酸
A derivative of 3-Hydroxymethyl-L-tyrosine, a homolog of DOPA. Both side-chain functionalities are protected simultaneously by acetonide formation, which is reverted during TFA cleavage. 1,3-Diols readily form acetals allowing selective peptide modification.
GA21845 Fmoc-α-amino-DL-Gly(Boc)-OH
Α-FMOC-Α'-BOC-二氨基乙酸
Has been used as a template for the introduction of betidamino acid in bioactive peptides. The structural constraints introduced by the presence of a betidamino acid were of particular interest in the identification of bioactive conformations of peptide hormones and for the design of receptor selective analogs.
GA21843 Fmoc-α-allyl-DL-Gly-OH
N-(9-芴基甲氧羰基)-烯丙基-DL-甘氨酸
Allylglycine-containing peptides may be cleaved selectively at the amide bond between allylglycine and the subsequent amino acid with iodine. The lateral vinyl bond allows selective modifications of a peptide e.g. via metathesis. The synthetic applications of aliphatic unsaturated α-amino acids as allylglycine have been reviewed by Kaiser et al.
GA21842 Fmoc-α-allyl-D-Gly-OH
Fmoc-D-烯丙基甘氨酸
Educt for the synthesis of protected enantiomerically pure 2-deoxystreptamine. Building block for obtaining carba analogs of disulfide-bridged peptides.
GA21827 Fmoc-Tyr(PO₃(MDPSE)₂)-OH
N-[(9H-芴-9-基甲氧基)羰基]-O-[双[2-(甲基二苯基硅烷基)乙氧基]磷酰]-L-酪氨酸
This protected phosphotyrosine derivative can be used as building block for the synthesis of phosphotyrosine peptides. The MDPSE-phosphate group is stable under the conditions used for repetitive removal of the Fmoc group, readily removable with TFA and stable at room temperature for several months.
GA21823 Fmoc-Tyr(Boc-Nmec)-OH Fmoc-Tyr derivative for improving the solubility of hydrophobic peptides after cleavage from the resin, as removal of Boc leaves a charged moiety. After purification, the solubilizing Nmec (N-methyl-N-[2-(methylamino)ethyl]carbamoyl) group is split off via an intramolecular cyclization in neutral or slightly basic solution.
GA21809 Fmoc-Thr(tBu)-ODhbt
N-芴甲氧羰基-O-叔丁基-L-苏氨酸-3,4-二氢-3-羟基-4-氧-1,2,3-苯并三嗪酯
ODhbt esters are more reactive than OPfp esters in peptide synthesis.
GA21798 Fmoc-Ser(tBu)-ODhbt
Fmoc-O-叔丁基-L-丝氨酸3,4-二氢-4-氧代-1,2,3-苯并三嗪-3-基酯
ODhbt esters are more reactive than OPfp esters in peptide synthesis.
GA21766 Fmoc-p-azido-Phe-OH
N-芴甲氧羰基-L-4-叠氮基苯丙氨酸
The azido group is sensitive towards piperidine. In Fmoc-SPPS, this derivative is best introduced as N-terminus or modified before elongating the peptide. B-2360 has been employed as a precursor of p-aminophenylalanine. Levinson et al. reduced the azido group on-resin with a large excess of tributylphosphine in DMF.
GA21765 Fmoc-p-azido-D-Phe-OH Fmoc-D-AzF can be incorporated in peptides as precursor of p-aminophenylalanine. Levinson et al. reduced the azido group on-resin with a large excess of tributylphosphine in DMF.
GA21745 Fmoc-N-Me-Arg(Pbf)-OH
FMOC-N-甲基-PBF-L-精氨酸
Derivative for synthesizing peptides containing Nα-methylated arginine, superior to Fmoc-N-Me-Arg(Mtr)-OH (4026642), as Pbf can be removed under much milder conditions.
GA21735 Fmoc-Lys(retro-Abz-Boc)-OH Fmoc-Lys(Boc-Abz)-OH a protected building block for the preparation of fluorescence-labeled peptides. The anthranilic acid attached at the side-chain of lysine is highly sensitive and its fluorescence spectrum does not overlap with those of Trp, Phe, and Tyr.
GA21706 Fmoc-L-cysteic acid . disodium salt Protected derivative for the introduction of this highly polar amino acid. Cya-containing peptides are obtained by oxidation of cysteine or cystine, as a post-translational modification, as a by-product during peptide synthesis, or, intentionally (by using oxidants as H?O?/formic acid), for quantification of these sensitive amino acids. Use of B-4030 allows to obtain Cya-peptides containing sensitive amino acids, as an additional oxidation step is not required.
GA21705 Fmoc-L-azetidine-2-carboxylic acid
1-氯甲酸芴甲酯-(S)-吖丁啶-2-羧酸
A suitable derivative for incorporating this strained proline analog in peptides to modify their conformation. Its influence on the stability of the collagen helix has been studied by Zagari et al. Fmoc-Aze-OH was employed in the solid-phase synthesis of potent cyclic GnRH analogs.
GA21699 Fmoc-Homocys(Trt)-OH
N-芴甲氧羰基-S-三苯甲基-L-高半胱氨酸
Educt for the synthesis of β-turn peptidomimetics (Jiang and Burgess). Lindman et al. obtained Hcy-containing angiotensin II analogs by Fmoc-SPPS. Homocysteine can function as thiol component during chemical ligation. S-Methylation of the resulting peptide yields methionine.
GA21670 Fmoc-Glu-2-phenylisopropyl ester Fmoc-Glu derivative for the synthesis and selective modification of γ-Glu containing peptides. The OPp group can be removed selectively in the presence of Boc/OtBu with 1% TFA/DCM.
GA21664 Fmoc-Glu(2-phenylisopropyl ester)-OH
N-[(9H-芴-9-基甲氧基)羰基]-L-谷氨酸5-(1-甲基-1-苯基乙基)酯
Glu-derivative for the selective modification of the γ-carboxyl group. The OPp group can be removed selectively in the presence of Boc/OtBu with 1% TFA/DCM. Ocampo et al. applied OPp protection during the synthesis of a peptide-oligonucleotide conjugate and cleaved it with 3% trichloroacetic acid in DCM. Tofteng et al. generated a backbone pyroglutamyl imide moiety from C-terminal Glu after selective on-resin OPp removal.
GA21649 Fmoc-D-Thr(PO(OBzl)OH)-OH Building block for the synthesis of phosphothreonine containing peptides.
GA21647 Fmoc-D-Ser(PO(OBzl)OH)-OH Building block for the synthesis of D-phosphoserine containing peptides.
GA21637 Fmoc-D-Lys(Z)-OH
N-芴甲氧羰基-N'-苄氧羰基-D-赖氨酸
Building block for short polar peptides containing D-lysine. They are easier to purify when Z-protected, because they become more lipophilic.
GA21604 Fmoc-D-Cys(4-methoxytrityl)-OH
N-[芴甲氧羰基]-S-[(4-甲氧基苯基)二苯基甲基]-D-半胱氨酸
4-Methoxytrityl (Mmt) is a very acid sensitive cysteine protecting group that can selectively be removed by 0.5 - 1.0% TFA in the presence of protecting groups of the t-butyl type and S-Trt. It can be used in the solid-phase synthesis of cysteine-containing peptides, and further to selectively protect a thiol function in order to introduce a labeling group.
GA21600 Fmoc-D-Asp(OtBu)-(Hmb)Gly-OH A building block for the synthesis of peptides containing the D-Asp-Gly motif avoiding base-catalyzed aspartimide formation.
GA21587 Fmoc-Dap(Fmoc)-OH
N-芴甲氧羰基-3-[(芴甲氧羰基)氨基]-L-丙氨酸
Suitable derivative for the Fmoc-SPPS of peptide dendrimers.
GA21564 Fmoc-Cys(StBu)-OH
亚芴甲氧羰基半胱胺酸
Was converted into the corresponding N-Me-Cys derivative in excellent yield. Educt for obtaining the Cys 4-methyl-2,6,7-trioxabicyclo[2,2,2]octyl (OBO) orthoester. The OBO ester was attached to a thiol resin as disulfide for obtaining peptides containing a C-terminal cysteine.
GA21562 Fmoc-Cys(SASRIN™ resin)-OH (200-400 mesh, 0.3-0.6 mmol/g) This resin has been developed to allow C-terminal modification of cysteine-containing peptides. Fmoc-protected cysteine is linked to SASRIN™-resin by its thiol moiety, which thus is already protected. After derivatization of the carboxylic acid (and, if desired, standard Fmoc-SPPS) lthe modified cysteine derivative can be cleaved with TFA/water/triisopropylsilane (94:4:2, v/v/v) from the SASRIN™-resin. Extending the peptide chain at the C-terminus can be achieved by activation of the side-chain linked cysteine carboxylic acid and coupling to additional amino acids. Cys linked to a resin by its thiol function was oxidized with MCPBA after esterification and Nα-modification (Yamada et al.). DBU-induced elimination yielded dehydroalanine derivatives.
GA21556 Fmoc-Cys(3-(Boc-amino)-propyl)-OH This protected trifunctional amino acid derivative, representing an analog of homolysine, can be used for introducing a lysine or arginine mimetic. It has been incorporated in ??Tc-chelating peptides.
GA21554 Fmoc-Cys((S)-2,3-di(palmitoyloxy)-propyl)-OH
1S)-1-[[[(2R)-2-羧基-2-[[芴甲氧羰基]氨基]乙基]硫基]甲基]-1,2-乙二基双(十六烷酸)酯
SPPS employing the pure stereoisomer of Fmoc-Pam?Cys-OH allows to obtain more homogeneous lipopeptides. The configuration of the bis-palmitoyloxypropyl moiety could influence the biological activity of the peptide conjugate.
GA21553 Fmoc-Cys((RS)-2,3-di(palmitoyloxy)-propyl)-OH Incorporation of Fmoc-Pam2Cys-OH yields more hydrophilic products than incorporation of Pam?Cys-OH (F-2630) due to the free amino group obtained after attachment and deprotection. Nevertheless, the H-Pam?-peptides show comparable adjuvant activity.
GA21552 Fmoc-Cys((R)-2,3-di(palmitoyloxy)-propyl)-OH
(1R)-1-[[[(2R)-2-羧基-2-[[芴甲氧羰基]氨基]乙基]硫基]甲基]-1,2-乙二基双(十六烷酸)酯
SPPS employing the pure stereoisomer of Fmoc-Pam2Cys-OH allows to obtain more homogeneous lipopeptides. The configuration of the bis-palmitoyloxypropyl moiety could influence the biological activity of the peptide conjugate. For Fmoc-(S)-Pam2Cys-OH see B-4335.
GA21548 Fmoc-cis-4-fluoro-Pro-OH
(2S,4S)-FMOC-4-氟吡咯烷-2-甲酸
Stabilizes the PPII helix in Pro-rich short peptides, though less efficiently than the trans isomer. Oligomers of flp were studied by Horng and Raines.
GA21539 Fmoc-Asp(OtBu)-(Hmb)Gly-OH Aspartimide formation of the highly base-labile Asp-Gly motif during Fmoc-SPPS may be completely suppressed by coupling this Hmb-protected dipeptide derivative. Additionally, Hmb prevents aggregation of the growing peptide chain as efficiently as the incorporation of a pseudoproline moiety. O-Acylation renders the Hmb moiety acid-stable facilitating the purification of peptides prone to form aggregates. The acyl group can be removed with hydrazine hydrate in DMF (cf. Quibell).
GA21536 Fmoc-Asp(ODmab)-OH
N-芴甲氧羰基-L-天冬氨酸4-[[4-[[1-(4,4-二甲基-2,6-二氧代环己亚基)-3-甲基丁基]氨基]苯基]甲基]酯
Dmab can be removed with 2% hydrazine in DMF generating an indazole which allows the UV-spectrophotometrical monitoring of the cleavage. Conroy et al. used this Asp derivative for the solid-phase synthesis of N-linked glycopeptides. As Dmab represents an unhindered p-substituted Z-derivative, Asp(Dmab)-containing peptides are prone to base-catalyzed aspartimide formation.
GA21535 Fmoc-Asp(EDANS)-OH
N2-[芴甲氧羰基]-N-[2-[(5-磺基-1-萘基)氨基]乙基]-L-天冬氨酰胺
Building block for the synthesis of internally quenched fluorogenic peptide substrates. The fluorescent group EDANS can be efficiently quenched by the nonfluorescent DABCYL chromophore.
GA21534 Fmoc-Asp(2-phenylisopropyl ester)-OH
N-(9-芴甲氧羰基)-天冬氨酸4-(2-苯基异丙基)酯
An aspartic acid derivative allowing specific side chain deprotection with 1% TFA in dichloromethane. Ocampo et al. applied OPp protection during the synthesis of a peptide-oligonucleotide conjugate and cleaved it with 3% trichloroacetic acid in DCM. The OPp derivative is far less prone towards base-catalyzed aspartimide formation than the OAll, OBzl, or ODmab esters, its stability comes close to the stability of the OtBu ester.
GA21528 Fmoc-Asn(Mtt)-OH Mtt carboxamide protection is superior to Trt when synthesizing peptides containing an N-terminal Asn, as the latter is cleaved only sluggishly in this position.

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