Search results for: 'Peptide'

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Cat.No. 产品名称 Information
GA23477 Relaxin H2 (human) Relaxin H2 is the major stored and circulating isoform of the peptide hormone relaxin in humans. This pregnancy hormone has also shown cardioprotective activity. The observed long-term effects of relaxin H2 on connective tissues may be due to alterations in the turnover of collagen and proteoglycans.
GA23476 rec β-Defensin 2 (human) β-Defensin 2 (BD-2) (human), an antimicrobial peptide, is expressed throughout the epithelia of many organs. BD-2 is inducible upon contact of keratinocytes with Gram-negative bacteria or proinflammatory cytokines such as TNF-α and IL-1β. Elevated expression has been detected in lesional epidermal keratinocytes both in psoriasis and in the inflamed skin of mastitis.
GA23475 rec β-Defensin 1 (human) β-Defensin 1 (BD-1) (human) is a small cationic peptide originally isolated from human plasma. It exerts antimicrobial activity and is constitutively expressed in epithelia at the mucosal surface. A role for BD-1 in innate immune response has been proposed.
GA23441 Ranalexin Ranalexin, isolated from the skin of the American bullfrog, Rana catesbeiana, is an amphibian antimicrobial peptide. It contains a single intramolecular disulfide bond which forms a heptapeptide ring within the molecule. Structurally, ranalexin resembles the bacterial antibiotic, polymyxin, which contains a similar heptapeptide ring.
GA23437 Pz-Pro-Leu-OH Cleavage product of Pz-peptide, M-1715, a substrate for collagenase and thimet oligopeptidase.
GA23432 Pyr-Trp-Gly-NH₂ The tripeptide pEWG-amide found in plasma stimulates the uptake of serotonin into platelets. Increased amounts of pEWG-amide can be detected in the urine of autistic children. The urinary peptide, which is generated from the CNS glycoprotein reelin, has also been associated with depression and anxiety disorders.
GA23391 Pseudin-2 Pseudin-2 is a cationic α-helical peptide originally isolated from the skin of the paradoxical frog Pseudis paradoxa on the basis of its antimicrobial activity. GLNALKKVFQGIHEAIKLINNHVQ stimulated insulin secretion from BRIN-BD11 cells by a Ca²?-independent mechanism.
GA23386 Procathepsin B (26-50) (rat) This 25 residue peptide was completely resistant to proteolysis by cathepsin B even after incubation overnight. It inhibited human cathepsin B with Ki = 2.8 µM and rat cathepsin B with Ki = 2 µM.
GA23383 Preptin (rat) Preptin is a 34-amino acid peptide hormone, which is co-secreted with insulin from the pancreatic β-cells in response to glucose stimulation. It is osteogenic in vitro and in vivo and may act in concert with the other β-cell hormones insulin and amylin to stimulate bone formation in hyperinsulinemic states such as obesity.
GA23380 Prepro-Killer Cell Immunoglobulin-Like Receptor 3DL3 (23-31) Riteau et al. carried out immunofluorescence analysis using a rabbit antiserum directed against the nonapeptide VGGQDKPFL corresponding to the N-terminal sequence of KIR2DL4. The peptide did not discriminate between p49 and KIR2DL4 receptor.
GA23373 Polybia-MP1 A mastoparan-related antimicrobial insect venom peptide selectively inhibiting the proliferation of prostate and bladder cancer cells.
GA23359 Perisulfakinin Perisulfakinin was originally isolated from the corpora cardiaca of the American cockroach, Periplaneta americana. The peptide, which shows sequence similarity to gastrin and cholecystokinin, stimulates hindgut contractions in the same species.
GA23351 PDGF Antagonist The 13-amino acid peptide derived from the primary sequence of the B-chain of PDGF was found to be an antagonist for PDGF α- and β-receptors. The sequence of H-8650, ANFLVWEIVRKKP, combines PDGF-BB 35-40 (loop I) and PDGF-BB 76-82 (loop III).
GA23350 PAR-3 (1-6) amide (human) A peptide agonist of PAR1 and PAR2
GA23349 PAR-2 (1-6) amide (human) (scrambled) LSIGKV-amide, a partially reversed human PAR-2 activating peptide serving as an inactive control for the PAR-2 agonist SLIGKV-amide (H-4624).
GA23342 PAL resin (200-400 mesh, 0.2-0.5 mmol/g) Useful for the synthesis of peptide amides using Fmoc strategy. Cleavage has been performed with 50 % TFA in CH?Cl? or 95% aqueous TFA. Scavengers may be required.
GA23335 Ovotransferrin (328-332) ACE-inhibitory peptide associated with antioxidant and anticoagulation properties, IC?? 20 μM.
GA23333 Ovalbumin (154-159) The hexapeptide TNGIIR exhibited higher inhibition of ACE than several other peptides tested in comparison, as found by Yu et al. The concentration of the peptide, necessary to inhibit 50% of the activity of ACE, was 70 μM.
GA23324 Orexin A (16-33) OXA 16-33 lacks the disulfide bridges of orexin A, but retains a part of the activity of full-length OXA/OXB. The peptide has been used in place of the intact neuropeptide.
GA23316 Octaarginine The cell-penetrating peptide octa-arginine is a potent inhibitor of proteasome activities.
GA23252 Neuropeptide GE A peptide derived by proteolytic cleavage from the rat melanin-concentrating hormone (MCH) precursor. Neuropeptide glycine-glutamic acid (NGE) was suggested to act as a neuroregulator.
GA23248 Neuromedin U-25 (porcine)
猪神经调节肽U-25
Neuromedin U-8 and neuromedin U-25 from porcine spinal cord are potent stimulators of rat uterus smooth muscle. Both peptides have also been reported to influence blood pressure in rats and dogs
GA23203 Monocyte Chemotactic Protein-1 (human)
C-C趋化因子2
Synthetic peptide.
GA23186 Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse) This peptide is as H-3958 a gp100 epitope that is recognized in the context of HLA-A2 by tumor-infiltrating lymphocytes (TIL) in vivo. PMEL 17 could be a melanogenic enzyme.
GA23175 Mca-Amyloid β/A4 Protein Precursor₇₇₀ (667-676)-Lys(Dnp)-Arg-Arg amide This fluorescent (FRET) peptide substrate contains the wild-type amyloid precursor protein (APP) β-secretase cleavage site. Mca-SEVKMDAEFRK(Dnp)RR- amide has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo. See also L-1905.
GA23173 Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide (human)
专用电脑软件
Mca-PLAQAV-Dpa-RSSSR-amide, a fluorogenic (FRET) peptide substrate for tumor necrosis factor (TNF) converting enzyme (TACE, ADAM-17 endopeptidase).
GA23169 Maxadilan Maxadilan, isolated from the salivary gland of the sand fly Lutzomyia longipalpis, is a potent vasodilator. The peptide specifically and potently activates the mammalian PAC1 receptor, one of the three receptors for PACAP.
GA23152 LQEQ-19 (mouse, rat) LQEQ-19 (VGF599-617) is a Pro-VGF-derived peptide that induces penile erection when injected into the paraventricular nucleus of male rats. The effect is mediated by increased nitric oxide production in the hypothalamic nucleus causing activation of paraventricular oxytocinergic neurons. LQEQ-19 also evoked thermal hyperalgesia when injected intrathecally into naÏve adult mice.
GA23145 LL-37 FKR LL-37 FKR (FK-21), C-terminal fragment of LL-37, showed antimicrobial activity and similar concentration-dependent chemotactic activities on granulocytes as the full-length peptide.
GA23143 LL-37 (37-1) Reverse LL-37 used as control peptide.
GA23142 Gly-His-Lys acetate salt
Liver-Cell Growth Factor acetate salt

Gly-His-Lys acetate salt is a tripeptide consisting of glycine, histidine, and lysine, which is primarily used in the field of biochemistry and peptide research.
GA23136 Leu-Valorphin-Arg Leu-Valorphin-Arg, LVVYPWTQR, corresponds to the sequence (32-40) of the β-,δ-,γ-, and ε-chains of human hemoglobin. It shows binding affinity for µ- and sigma-opioid receptors and has opioid activity in the GPI bioassay. LVV-Hemorphin-6 is found in large amounts in the pituitary and seems to be present in the circulation to a much lesser degree. In view of its high stability towards the membrane-bound lung enzymes and its strong inhibitory action on ACE activity, LVV-hemorphin-6 appears to be the most potent of the hemorphin-related peptides assayed.
GA23131 Lepirudin
来匹卢定
Synthetic peptide. Lepirudin is an anticoagulant which functions as a direct thrombin inhibitor.
GA23129 Lauric acid-OSu
2,6-二甲基吡啶
Suitable for the synthesis of lauroyl derivatives of amines and thiols. Reagent for the modification of peptides to increase their lipophilicity.
GA23118 KR-12 amide (human) KR-12 corresponds to amino acid residues 18-29 of LL-37 and is the smallest peptide of LL-37 retaining antibacterial activity. KR12 displays a selective toxic effect on bacteria but not on human cells. It may be used as a template for developing novel antimicrobial agents of therapeutic use.
GA23102 IL-6 (88-121) (human) IL-6 (88-121) competitively inhibits the binding of human IL-6 to its receptor by interacting with the IL-6 receptor to a significant degree. It is suggested that this peptide comprises a part of the receptor-binding region of IL-6.
GA23100 IGF-I Analog The IGF-I peptide analog JB-1 was able to inhibit the autophosphorylation of the IGF-I receptor by IGF-I as well as the growth of several different cell types, including prostate carcinoma cells and SV40-transformed cells. IGF1 analogs as JB-1 might be useful in treating abnormal cell growth.
GA23034 Hydrin 1' The Xenopus peptide hydrin 1' shows equivalent aldosterone-releasing activity compared to hydrin 1 and is also effective in stimulating water flux from the isolated toad bladder.
GA23013 H-Val-Leu-His-Asp-Asp-Leu-Leu-Glu-Ala-OH HA-1H peptide, epitope presented by HLA-A*0201.
GA23009 H-Val-Gly-Ser-Glu-OH Eosinophilic chemotactic tetrapeptide also used as model peptide.
GA22994 H-Tyr-Tyr-Tyr-Tyr-Tyr-Tyr-OH 六酪氨酸已被用作模型肽，例如，在质谱分析中。
GA22992 H-Tyr-Tyr-Tyr-OH
L-酪氨酰-L-酪氨酰-L-酪氨酸
The bitter taste of tri-tyrosine, YYY, is due to its marked hydrophobicity. Narai-Kanayama and Aso showed that Tyr-Tyr (G-3480) and Tyr-Tyr-Tyr efficiently inhibit angiotensin I-converting enzyme (ACE) from rabbit lung, their IC?? values were 34 μM and 51 μM, respectively. These two tyrosine peptides exhibited a mix of competitive and noncompetitive inhibitions.
GA22991 H-Tyr-Tyr-OH
L-Tyrosyl-L-tyrosine
Narai-Kanayama and Aso showed that Tyr-Tyr and Tyr-Tyr-Tyr (H-5230) efficiently inhibit angiotensin I-converting enzyme (ACE) from rabbit lung, their IC?? values were 34 μM and 51 μM, respectively. These two tyrosine peptides exhibited a mix of competitive and noncompetitive inhibitions.
GA22978 H-Tyr-L-1,2,3,4-tetrahydroisoquinoline-3-carboxamide . HCl Tyr-Tic-amide and its epimer are the first example for opioid peptides consisting of a message domain of only two residues. In addition, they are the first opioid dipeptides with significant opioid activity and represent a first meaningful link among peptide opioids and alkaloid opiates and thus may form the basis for an unified receptor site model. It has been shown furthermore that peptides containing the Tyr-Tic motif , as TIPP H-5776, act as very selective antagonists for δ-opioid receptors and those containing Tyr-D-Tic as non-selective μ-agonists.
GA22944 H-Trp-Gly-Tyr-OH Model peptide for studies of charge transfer in peptides by iodine oxidation.
GA22942 H-Trp-Gly-Gly-Tyr-OH Synthetic peptide for studies of charge transfer in peptides by iodine oxidation.
GA22929 H-Thr-Pro-Asn-Gln-Arg-Gln-Asn-Val-Cys-OH The nonapeptide TPNQRQNVC peptide is the naturally presented epitope at the cell surface by HLA-B7 molecules recognized by CTL RP1
GA22907 H-tBu-D-Gly-OH
D-叔亮氨酸
Both Tle enantiomers are components of the polytheonamides, highly cytotoxic linear peptides from the marine sponge Theonella swinhoei.
GA22870 H-Pro-Thr-His-Ile-Lys-Trp-Gly-Asp-OH Tuna Muscle Peptide, PTHIKWGD, an angiotensin I-converting enzyme (ACE) inhibitor originally isolated from tuna muscle.
GA22867 H-Pro-Pro-Pro-Pro-OH Tetraproline. PPPP was used as an internal standard in the quantitative determination of the antihypertensive (ACE-inhibiting) peptides IPP and VPP in cheese by HPLC-MS³.

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