Search results for: 'Peptide'

类别: Aminopeptidase ACE Calpains Cathepsin Gamma Secretase MMP Thrombin Other Proteases Endogenous Metabolite Mitochondrial Metabolism PAI-1 Ser/Thr Protease Caspase Bax Bcl-2 Family IAP TNF-α Other Apoptosis PD-1/PD-L1 interaction Pyroptosis Histone Acetyltransferases Histone Demethylases Histone Methyltransferase HIF Protein Ser/Thr Phosphatases Citrullination Histones/Histone Peptides PPAR Neuronal Metabolism P450 Others Bone Growth & Remodeling Carbohydrate Metabolism Cofactors & Vitamins Dyslipidemias Metabolic Syndrome Necrosis Nutrient Sensing Reproductive Biology Sterol Biosynthesis PKA p38 JNK cAMP Broad Spectrum Protein Kinase Inhibitor EGFR Insulin Receptor Src Trk ATM/ATR CDK DNA/RNA Synthesis Casein Kinase Akt AMPK GSK-3 PI3K S6 Kinase Antibiotic HCV HIV Antifungal Bacterial Parasite SARS-CoV Coronaviruses Dengue Entry/Fusion Inhibitors Yellow Fever COVID-19 Antiviral Microtubule/Tubulin Dynamin ECM & Adhesion Molecules Cytoskeleton & Motor Proteins Endomembrane System & Vesicular Trafficking Proteolysis Autophagy Proteasome STAT PKC Integrin PAR1 Neuropeptide FF/AF Receptors Formyl Peptide Receptors 5-HT Receptor Adrenergic Receptor Apelin Receptor Angiotensin Receptor Bombesin Receptors Bradykinin Receptors Calcitonin and Related Receptors Cannabinoid Receptor CaSR CCK1 Receptors CCR Chemokine Receptors CRF2 Receptors CXCR Endothelin Receptor ETB Receptors Galanin Receptors Ghrelin Receptors GIP Receptor Glucagon Receptor Melanin-concentrating Hormone Receptors Melanocortin (MC) Receptors Motilin Receptor Non-selective CRF Neurotensin Receptors NOP Receptor NPY Receptors Orphan 7-TM Receptors OX Receptor Oxytocin Receptors Peptide Receptors Protease-Activated Receptors Secretin Receptors Somatostatin Receptor Vasopressin Receptor Ras Urotensin-II Receptor VIP Receptors Neuromedin U Receptors mAChR Neurokinin Receptor Notch Wnt/β-catenin Cancer stem cell YAP AMPAR Calcium Channel Pannexin-1 Potassium Channel TRP Channel Kainate Receptors Na+/K+ ATPase iGluR Cancer Biology Peptides Ras-like GTPases Tumor Microenvironment Cell Migration & Metastasis GnRH Opioid Receptor Thyroid hormone Receptor TRH Glucocorticoids & Mineralocorticoids AChR Alzheimer Amyloid β CGRP DAPK Gap Junction GluR Histamine Receptor Neuroscience Peptides Nicotinic Receptor Substance P/NK1 Receptor CaMK Behavioral Neuroscience Neuroendocrinology Neuroprotection Ophthalmology Pain Research Parkinson Prion Diabetes NAFLD & NASH Obesity Peptide Inhibitors and Substrate Other Signal Transduction Papain TLR NF-κB Interleukin Related Complement System IFNAR NO Synthase NOD-like Receptor (NLR) STING Reactive Oxygen Species Apoptosis Glutathione Adaptive Immunity Allergy Arthritis Autoimmunity Gastric Disease Innate Immunity Pulmonary Diseases PSMA Acute Phase Reactants Arrhythmia Atherosclerosis Chronic Kidney Disease Coagulation & Hemostasis Diabetic Nephropathy Endothelium Erythrocytes & Hemoglobin Heart Failure Hypertension Hypotension Lipoproteins Myocardial Contractility Myocardial Hypertrophy Myocardial Infarction Serum Proteins Smooth Muscle Cells Stroke Vasoconstriction Thrombosis Vasodilation ADC Cytotoxin ADC Linker Drug-Linker Conjugates for ADC PROTAC Antioxidants Carbohydrate Oxidation Lipid Peroxidation Pro-Oxidant Activity Adenylate cyclase AT Receptors Cell Penetrating Peptide Cytokine Enzyme Substrates / Activators Fluorescent Probes Glycoprotein Guanylate Cyclase Guanylyl Cyclase MDR multidrug resistance Myosin Natriuretic Peptide Receptors Nitric Oxide Renin Tachykinin Transcription Factors Cyclase Toxicology Antiparasitics Toxins Peptide Coupling Reagents Amino Acids and Derivatives N-Protecting Reagents Other Reagents Other Resin and Derivatives Natural Products Screening Library Cyanine Dyes Affinity Probes Enzyme Substrates Fluorescence Biochemical Assay Reagents B type Natriuretic Peptide Transferase Insulin Macrophage Migration Inhibitory Factor GHRP GLP Glucagon Peptide Hormones Other Natural Proteins Other Superoxide Dismutase SARS Leukotrienes Lipid-Based Drug Delivery Prostaglandins Neuropeptides Tag Peptides Amyloid β protein Inhibitors and Substrates Peptide Epitopes Peptides for Drug Delivery Featured Products Food-Borne Illnesses MRSA Pneumonia STDs Tuberculosis Candidiasis Leishmaniasis Quorum Sensing Hepatitis

Cat.No. 产品名称 Information
GC45714 ZK 756326 (hydrochloride) A non-peptide agonist of CCR8
GC45666 Palmitoyl Tripeptide-5 (trifluoroacetate salt)
棕榈酰三肽-5
A cosmeceutical peptide
GC45641 Acetyl Octapeptide-3
乙酰八胜肽-1
A cosmeceutical peptide
GC38287 α-Pyridone
2-羟基吡啶,Pyridin-2-one; α-Hydroxypyridine
2-Hydroxypyridine (2-Pyridino, 2-Pyridone) is used in peptide synthesis.
GC38168 Heterophyllin B
太子参环肽B
Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla, which provides a novel strategy for the treatment of esophageal cancer.
GC38148 Etelcalcetide
维拉卡肽,AMG 416; KAI-4169
A peptide agonist of CaSR
GC38147 Etelcalcetide hydrochloride
维考西肽盐酸盐,AMG 416 hydrochloride; KAI-4169 hydrochloride
A peptide agonist of CaSR
GC38109 Enfuvirtide acetate
醋酸恩夫韦地; T20 acetate; DP178 acetate
A peptide inhibitor of HIV-1 fusion
GA24015 ε-Maleimidocaproic acid-(2-nitro-4-sulfo)-phenyl ester . sodium salt
Ε-N-马来酰亚胺己酸(2-N-4-S)苯酯钠盐
mal-sac-HNSA, an often used freely water-soluble, heterobifunctional crosslinking reagent for conjugation of sulfhydryl (cysteine)-containing peptides to carrier proteins. The reaction of mal-sac-HNSA with amino groups can be monitored spectrophotometrically due to the concomitant release of the dianion of 1-hydroxy-2-nitro-4-benzenesulfonic acid.
GA24012 β-Neoendorphin A hypothalamic opioid peptide related to Leu-enkephalin and dynorphin A with potent activity in the guinea-pig ileum assay.
GA24006 β-Defensin 2 (human) An antimicrobial peptide
GA24003 β-Casomorphin (1-2) The antihypertensive peptide isolated from fermented milk had a low inhibitory activity against angiotensin I-converting enzyme (ACE), IC? ? 720 μM. G-3625 is a possible biosynthetic precursor of endomorphin.
GA24000 α-Synuclein (71-82) (human)
Α-突触核蛋白Α-SYNUCLEIN(71-82)(HUMAN)
The deposition of α-synuclein (α-syn) fibrils in Lewy bodies is a characteristic feature of individuals with neurodegenerative disorders. The central hydrophobic region of α-synuclein, resembled by the peptide α-synuclein (71-82), is believed to be responsible for the protein aggregation. In addition, α-synuclein (71-82) forms amyloid fibrils of similar morphology to α-synuclein, suggesting that this region contributes to the fibrillogenic core of the full-length protein, referring to the studies of Madine and coworkers.
GA23999 α-Synuclein (67-78) (human)
Α-突触核蛋白Α-SYNUCLEIN(67-78)(HUMAN)
The Parkinson's disease-associated protein α-synuclein (α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. Two distinct cholesterol-binding domains in α-synuclein were identified by Fantini and coworkers. The tilted peptide of α-synuclein (67-78) bound cholesterol with high affinity and was toxic for cultured astrocytes. A cholesterol recognition consensus motif with lower affinity for cholesterol and devoid of toxicity, is encased in the glycosphingolipid-binding domain (34-45) of α-synuclein. The authors propose that the association of α-synuclein with lipid rafts involves both the binding of α-synuclein (34-45) to glycosphingolipids, and the interaction of α-synuclein (67-78) with cholesterol.
GA23996 α-Synuclein (34-45) (human)
Α-突触核蛋白Α-SYNUCLEIN(34-45)
The Parkinson's disease-associated protein α-synuclein (α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. Two distinct cholesterol-binding domains in α-synuclein were identified by Fantini and coworkers. The tilted peptide of α-synuclein (67-78) bound cholesterol with high affinity and was toxic for cultured astrocytes. A cholesterol recognition consensus motif with lower affinity for cholesterol and devoid of toxicity, is encased in the glycosphingolipid-binding domain (34-45) of α-synuclein. The authors propose that the association of α-synuclein with lipid rafts involves both the binding of α-synuclein (34-45) to glycosphingolipids, and the interaction of α-synuclein (67-78) with cholesterol.
GA23995 α-Neoendorphin A hypothalamic opioid peptide related to Leu-enkephalin and dynorphin A with potent activity in the guinea-pig ileum assay.
GA23989 α-Defensin 6
α-防御素-6
Cysteine-rich cationic peptide with antiviral activity against HSV infection and a role in N. gonorrhoeae-mediated HIV enhancement. In contrast to the other members of the ƒ-defensin family it shows very low antimicrobial activity against Gram-negative and Gram-positive bacteria. As a biomarker of colon adenocarcinoma it may have utility in colon cancer screening and diagnosis.
GA23986 α-Casein (90-96) α-Casein exorphin is a δ-selective opioid receptor ligand acting as an opioid agonist. RYLGYLE is also used as model peptide
GA23963 Z-Val-Ala-DL-Asp-fluoromethylketone zVAD-FMK inhibited apoptosis induced by diverse stimuli. Preincubation of cells with this caspase-1 (ICE) inhibitor (50 µM) almost completely inhibited the formation of large kilobase-pair fragments of DNA, a characteristic biochemical change associated with apoptosis. Z-VAD-FMK was shown to irreversibly inhibit most types of caspases, hence it is also called pan-caspase inhibitor. For a cell-permeable analog see N-1560. Inhibitor of peptide:N-glycanase (PNGase).
GA23962 Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone
N-[(苯基甲氧基)羰基]-L-缬氨酰基-N-[3-氟-1-(2-甲氧基-2-氧代乙基)-2-氧代丙基]-L-丙氨酰胺
Z-VAD(OMe)-FMK, a pan-caspase inhibitor, is a competitive irreversible peptide inhibitor and blocks caspase-1 family and caspase-3 family enzymes. The methyl ester of Z-VAD-FMK has been used in studies to support the hypothesis that inhibitors of caspases can limit brain infarction resulting from the permanent obstruction of a brain artery.
GA23895 Z-Phe-Arg-OMe . HCl Z-FR-OMe, substrate for peptide synthesis catalyzed by by a recombinant cysteine protease, cathepsin L1 from liver fluke (Fasciola hepatica).
GA23851 Z-Leu-Leu-4,5-dehydro-Leu-aldehyde The peptide aldehyde SIB1281 inhibited the formation of β- and γ-secretase derived amyloid β-protein (Aβ) with IC?? = 1.8 µM and stimulated the formation of α-secretase derived soluble amyloid precursor protein (sα) with an EC?? of 250 nM.
GA23837 Z-His-Phe-Phe-OEt zHFFe, a good substrate for pepsin. Hertel et al identified zHFFe as a potent inhibitor of zero-trans glucose flux with a Ki of 26 μM. Similar to HIV protease inhibitors, transport inhibition by this peptide was acute, non-competitive, and reversible. Within a Xenopus oocyte expression system, zHFFe acutely and reversibly inhibited GLUT4-mediated glucose uptake, whereas GLUT1 activity was unaffected at concentrations as high as 1 mM.
GA23822 Z-Gly-Pro-Leu-Gly-Pro-OH Substrate for collagenase and for prolyl endopeptidase (post-proline cleaving enzyme). Cleavage of Z-GPLGP yields Z-Gly-Pro-OH (C-1880) and H-Leu-Gly-Pro-OH (H-3895), an antihypertensive peptide.
GA23815 Z-Gly-Phe-OH
N-苄氧羰基甘氨酰-L-苯丙氨酸
Substrate for carboxypeptidase A. The peptide is also an effective deactivating carrier into cells for primary and secondary amines, which are then unmasked intracellularly by enzymatic action.
GA23769 Z-D-Phe-Phe-Gly-OH A high level of inhibition of virus replication was obtained with this peptide, which resembles a region of a viral polypeptide.
GA23727 Z-Asp-Gln-Met-Asp-AFC Ac-DQMD-AFC, fluorogenic substrate for caspase-3. It contains the DQMD peptide sequence of the baculovirus caspase inhibitor p35.
GA23665 VIP Antagonist VIP antagonist, a hybrid of neurotensin (6-11) and VIP (7-28), is a competitive antagonist of VIP-binding to glial cells. In rats with reduced masculine potential, The peptide markedly inhibits VIP-stimulated sexual behaviour. Furthermore, it has been shown to antagonize VIP receptors on non-small cell lung cancer cells, thereby inhibiting tumor growth in vitro and in vivo.
GA23664 Vesicular Stomatitis Virus Nucleoprotein (52-59) VSV-8, RGYVYQGL, corresponds to positions 52 to 59 of vesicular stomatitis virus (VSV) nucleoprotein which is expressed in the cytosol of cells infected by VSV. CTL response against VSV in H-2Kb mice is directed against this immunodominant peptide. VSV-8 forms a complex with murine MHC class I molecule H-2Kb, which is similar to human HLA class I.
GA23663 Urotensin II (goby) A peptide vasoconstrictor
GA23662 Uroguanylin Topoisomer B (human) Short peptides containing two disulfide bridges can form interconvertible topoisomers with the same disulfide connectivity. In case of uroguanylin (UGN), both are relatively stable and can be separated, and interconversion is slow. The topoisomers differ in biological activity: The UGN A topomer potently activates the guanylate cyclase C receptor found primarily in the intestine. The B topomer is a very weak agonist of this receptor. Moss et al. could show that UGN B has potent natriuretic activity in the kidney.
GA23655 Tyrosinase (206-214) (human) AFLPWHRLF is a tyrosinase epitope recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL). Therefore it represents a reagent that may be used to generate melanoma-specific T cells for adoptive immunotherapy, as well as in peptide vaccines for HLA-A24+ melanoma patients.
GA23654 Tyrosinase (192-200) (human, mouse) SEIWRDIDF, antigenic peptide presented by HLA-B44 and recognized on a human melanoma by autologous cytolytic T lymphocytes.
GA23642 Tricyclic amide linker resin (DL-form) (200-400 mesh, 0.5-0.8 mmol/g) Ramage resin is highly suitable for the preparation of peptide amides by the Fmoc-strategy and is recommended for C-terminal Phe, Tyr and Ile. Cleavage has been performed with 50 % TFA in CH?Cl? or 95% aqueous TFA. Scavengers may be required. Tricyclic amide linker resin has been used for the synthesis of fluorogenic substrates for continuous assay of aminopeptidase P. glpbio additionally offers the Ramage amide linker (Q-2745) to be coupled to other types of carrier resin.
GA23640 TRH-Gly TRH-Gly is the direct precursor of TRH; the glycine is cleaved by an α-amidating enzyme to form the C-terminal amide. Significant concentrations of the tetrapeptide, however, have been found in hypothalamus, pituitary, thyroid, and peripheral blood of rats as well as in human cerebrospinal fluid. Several data suggest that the peptide is also biologically active.
GA23637 TRAP-5 amide
SFLLR-NH₂
TRAP-5 amide，也称为SFLLR-amide，是一种蛋白酶激活受体1（PAR 1）激动剂肽。
GA23632 Toxin GaTx1 GaTx1 is a component of the venom of the yellow scorpion (Leiurus quinquestriatus hebraeus). The highly bridged 34-peptide, a chloride channel ligand, potently and reversibly inhibits cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels when the channels are in the interburst closed state. Since the toxin inhibits CFTR only when applied to the cytoplasmic side, it is unlikely that CFTR represents the native target. Manufactured and sold under license from Georgia Tech Research Corporation, USA; patent WO/2007/137163 (PCT/US2007/069243).
GA23631 Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) TSST-1 is a "superantigen" which binds to MHC class II molecules and induces stimulation of T cells. This TSST-1 fragment has an active site of the TSST-1 holotoxin which binds to MHC class II molecules and is able to xenostimulate T cells in an MHC unrestricted manner. Therefore this peptide could be of great value in studying the immunobiology of MHC class II molecules.
GA23630 TOTT
2-(1-氧化吡啶-2-基)-1,1,3,3-四甲基异硫脲四氟硼酸盐
Reagent for peptide coupling and amidation reactions.
GA23611 Thymosin β₁₀ (human, rat)
胸腺BETA10
Thymosin β?? is differentially expressed in embryogenesis and neuronal development. Overexpression of the peptide has also been observed in many inflammatory conditions and in a variety of human cancers.
GA23606 TGF α (34-43) (rat) The fragment CHSGYVGVRC comprises the third disulfide loop of rat TGF α. Antibodies elicited against the synthetic decapeptide crossreacted with native TGF α but not EGF. The peptide competed with EGF for binding to its receptors and was found to be an antagonist of EGF-induced mitogenesis. More recent results indicate that administration of TGF α (34-43) inhibits the development of gastric cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine.
GA23601 Teplow's Amyloid β-Protein (1-42) (scrambled II) This peptide is a specifically designed negative control in studies with Abeta42. It is "scrambled", which means it contains the same amino acids as Abeta42, but in different order. Referring to studies by Yamin and coworkers, Teplow's Amyloid β-Protein (1-42) does not show a number of phenomena regularly observed with Abeta42 (fibril formation, oligomerization, toxicity to neurons) and furthermore has a relatively flat hydropathy profile, which can be an advantage in several studies, for example in order to avoid unspecific interaction with the cell membrane.
GA23600 Teplow's Amyloid β-Protein (1-40) (scrambled II) This peptide is a specifically designed negative control in studies with Abeta40. It is "scrambled", which means it contains the same amino acids as Abeta40, but in different order. Referring to studies by Yamin and coworkers, Teplow's Amyloid β-Protein (1-40) does not show a number of phenomena regularly observed with Abeta40 (fibril formation, oligomerization, toxicity to neurons) and furthermore has a relatively flat hydropathy profile, which can be an advantage in several studies, for example in order to avoid unspecific interaction with the cell membrane.
GA23564 Suc-Phe-Gly-Leu-βNA Suc-FGL-βNA, substrate for the characterization of an LHRH-degrading neutral endopeptidase which is now known as thimet oligopeptidase (metalloendopeptidase 24.15, Pz-peptidase, collagenase-like peptidase). This enzyme has a ubiquitous distribution in mammals and, besides LHRH, cleaves various other bioactive peptides such as bradykinin and neurotensin.
GA23517 Substance P (4-11) The octapeptide substance P (4-11), PQQFFGLM-amide, seems to be more active than the natural peptide in various pharmacological tests in vitro and in vivo. Octa-substance P was shown to be an agonist of the NK1 receptor, IC?? 15 nM.
GA23510 SPARC (119-122) (mouse) SPARC is a transiently expressed extracellular matrix-binding protein that alters cell shape and regulates endothelial cell proliferation in vitro. KGHK, a copper-binding peptide fragment, has been shown to be a potent stimulator of angiogenesis. Specific degradation of SPARC by proteases of the extracellular fluid may release this bioactive tetrapeptide. Acetylated KGHK is used as cosmetic ingredient.
GA23506 Sodefrin Sodefrin has first been isolated from the abdominal gland of the cloaca of the male red-bellied newt, Cynops pyrrhogaster. It showed a species specific female-attracting activity. It is the first amphibian pheromone to be identified and the first peptide pheromone identified in a vertebrate.
GA23504 Sex Pheromone Inhibitor iPD1
性激素抑制剂IPD1
The octapeptide ALILTLVS is produced by Streptococcus faecalis donor strains harboring bacteriocin plasmid pPD1. It inhibits the activity of sex pheromone cPD1. The non-polar peptide iPD1 is also used for calibration in mass spectrometry.
GA23503 Serpinin (mouse, rat) Serpinin is a chromogranin A (CgA)-derived peptide. It has been identified to be a key molecule which induces dense-core secretory granules (DCG) biogenesis by up-regulating protease nexin-1 (PN-1) expression in an activity-dependent manner in endocrine cells.
GA23502 Seminalplasmin Fragment (SPF) Analog SPF, the hydrophobic 13-residue fragment (28-40) of the antimicrobial peptide seminalplasmin, possesses antibacterial and hemolytic activities. SPFK, the SPF analog in which Glu³² has been replaced by Lys, exhibits potent antibacterial activity at concentrations at which erythrocyte lysis does not occur.

Products for Category