Search results for: 'Peptide'

类别: Aminopeptidase ACE Calpains Cathepsin Gamma Secretase MMP Thrombin Other Proteases Endogenous Metabolite Mitochondrial Metabolism PAI-1 Ser/Thr Protease Caspase Bax Bcl-2 Family IAP TNF-α Other Apoptosis PD-1/PD-L1 interaction Pyroptosis Histone Acetyltransferases Histone Demethylases Histone Methyltransferase HIF Protein Ser/Thr Phosphatases Citrullination Histones/Histone Peptides PPAR Neuronal Metabolism P450 Others Bone Growth & Remodeling Carbohydrate Metabolism Cofactors & Vitamins Dyslipidemias Metabolic Syndrome Necrosis Nutrient Sensing Reproductive Biology Sterol Biosynthesis PKA p38 JNK cAMP Broad Spectrum Protein Kinase Inhibitor EGFR Insulin Receptor Src Trk ATM/ATR CDK DNA/RNA Synthesis Casein Kinase Akt AMPK GSK-3 PI3K S6 Kinase Antibiotic HCV HIV Antifungal Bacterial Parasite SARS-CoV Coronaviruses Dengue Entry/Fusion Inhibitors Yellow Fever COVID-19 Antiviral Microtubule/Tubulin Dynamin ECM & Adhesion Molecules Cytoskeleton & Motor Proteins Endomembrane System & Vesicular Trafficking Proteolysis Autophagy Proteasome STAT PKC Integrin PAR1 Neuropeptide FF/AF Receptors Formyl Peptide Receptors 5-HT Receptor Adrenergic Receptor Apelin Receptor Angiotensin Receptor Bombesin Receptors Bradykinin Receptors Calcitonin and Related Receptors Cannabinoid Receptor CaSR CCK1 Receptors CCR Chemokine Receptors CRF2 Receptors CXCR Endothelin Receptor ETB Receptors Galanin Receptors Ghrelin Receptors GIP Receptor Glucagon Receptor Melanin-concentrating Hormone Receptors Melanocortin (MC) Receptors Motilin Receptor Non-selective CRF Neurotensin Receptors NOP Receptor NPY Receptors Orphan 7-TM Receptors OX Receptor Oxytocin Receptors Peptide Receptors Protease-Activated Receptors Secretin Receptors Somatostatin Receptor Vasopressin Receptor Ras Urotensin-II Receptor VIP Receptors Neuromedin U Receptors mAChR Neurokinin Receptor Notch Wnt/β-catenin Cancer stem cell YAP AMPAR Calcium Channel Pannexin-1 Potassium Channel TRP Channel Kainate Receptors Na+/K+ ATPase iGluR Cancer Biology Peptides Ras-like GTPases Tumor Microenvironment Cell Migration & Metastasis GnRH Opioid Receptor Thyroid hormone Receptor TRH Glucocorticoids & Mineralocorticoids AChR Alzheimer Amyloid β CGRP DAPK Gap Junction GluR Histamine Receptor Neuroscience Peptides Nicotinic Receptor Substance P/NK1 Receptor CaMK Behavioral Neuroscience Neuroendocrinology Neuroprotection Ophthalmology Pain Research Parkinson Prion Diabetes NAFLD & NASH Obesity Peptide Inhibitors and Substrate Other Signal Transduction Papain TLR NF-κB Interleukin Related Complement System IFNAR NO Synthase NOD-like Receptor (NLR) STING Reactive Oxygen Species Apoptosis Glutathione Adaptive Immunity Allergy Arthritis Autoimmunity Gastric Disease Innate Immunity Pulmonary Diseases PSMA Acute Phase Reactants Arrhythmia Atherosclerosis Chronic Kidney Disease Coagulation & Hemostasis Diabetic Nephropathy Endothelium Erythrocytes & Hemoglobin Heart Failure Hypertension Hypotension Lipoproteins Myocardial Contractility Myocardial Hypertrophy Myocardial Infarction Serum Proteins Smooth Muscle Cells Stroke Vasoconstriction Thrombosis Vasodilation ADC Cytotoxin ADC Linker Drug-Linker Conjugates for ADC PROTAC Antioxidants Carbohydrate Oxidation Lipid Peroxidation Pro-Oxidant Activity Adenylate cyclase AT Receptors Cell Penetrating Peptide Cytokine Enzyme Substrates / Activators Fluorescent Probes Glycoprotein Guanylate Cyclase Guanylyl Cyclase MDR multidrug resistance Myosin Natriuretic Peptide Receptors Nitric Oxide Renin Tachykinin Transcription Factors Cyclase Toxicology Antiparasitics Toxins Peptide Coupling Reagents Amino Acids and Derivatives N-Protecting Reagents Other Reagents Other Resin and Derivatives Natural Products Screening Library Cyanine Dyes Affinity Probes Enzyme Substrates Fluorescence Biochemical Assay Reagents B type Natriuretic Peptide Transferase Insulin Macrophage Migration Inhibitory Factor GHRP GLP Glucagon Peptide Hormones Other Natural Proteins Other Superoxide Dismutase SARS Leukotrienes Lipid-Based Drug Delivery Prostaglandins Neuropeptides Tag Peptides Amyloid β protein Inhibitors and Substrates Peptide Epitopes Peptides for Drug Delivery Featured Products Food-Borne Illnesses MRSA Pneumonia STDs Tuberculosis Candidiasis Leishmaniasis Quorum Sensing Hepatitis

Cat.No. 产品名称 Information
GA20922 Boc-Cys(Me)-OH Educt for the synthesis of potential inhibitors of the glycosphingolipid biosynthesis (Brenner-Weiss et al.). Cys(Me) (Smc) can be incorporated in peptides as precursor of dehydroalanine. Dha-containing peptides are key intermediates in the synthesis of lantibiotics.
GA20739 Amyloid β-Protein (1-6) amide Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice. Amidated or acetylated and amidated forms of the sequence were used for example for quantitative structure retention relationships (QSRR) experiments. The latter could allow prediction of reversed-phase high-performance liquid chromatography (HPLC) retention of peptides, as reported by Kaliszan and coworkers.
GA20727 Amyloid β-Protein (1-39) Small quantities of Aβ37, 38 and 39 can be detected in CSF together with Aβ40, the most abundant Aβ homolog, Aβ42, and N-terminally truncated amyloid peptides. The relative amounts depend on the variant of Alzheimer's disease. The C-terminally truncated amyloid peptides are also found in amyloid plaques.
GA20720 Amyloid β-Protein (10-35) Amyloid β-protein (10-35), YEVHHQKLVFFAEDVGSNKGAIIGLM, was used as a truncated peptide model for the full-length amyloid β-proteins (1-40) and (1-42) in high-resolution structural studies. In contrast to the full-length amyloid β-proteins, amyloid β-protein (10-35) allowed the controlled and reproducible formation of homogeneous fibrils from aqueous solutions of defined pH, ionic strength and soluble peptide concentration necessary for high-resolution structural studies.
GA20565 Ac-Glu-Ser-Met-Asp-aldehyde (pseudo acid)
乙酰基-谷氨酰-丝氨酰-蛋氨酰-天冬氨醛
The peptide aldehyde Ac-ESMD-CHO corresponds to one of the cleavage sites of the inactive 32 kD caspase-3 precursor (amino acids 25-28). In a concentration range of 2.5 - 5 µM, it blocked the formation of the p17 subunit and concomitantly induced the accumulation of the p20 peptide.
GA20535 Acetyl-Amyloid β-Protein (1-6) amide Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice. Amidated or acetylated and amidated forms of the sequence were used for example for quantitative structure retention relationships (QSRR) experiments. The latter could allow prediction of reversed-phase high-performance liquid chromatography (HPLC) retention of peptides, as reported by Kaliszan and coworkers.
GA20533 Acetyl-Amyloid β/A4 Protein Precursor₇₇₀ (96-110) (cyclized)
乙酰基-淀粉样肽Β/A4蛋白质前体770(APP)(96-110)(环化)
This cyclized peptide which is homologous to the heparin-binding domain of APP, binds strongly to heparin and inhibits binding of ¹²?I-labeled APP to heparin (IC??= 10??M). The peptide blocks the heparan sulfate proteoglycan-dependent stimulatory effect of APP on neurite outgrowth.
GA20491 Ac-Asp-Arg-Leu-Asp-Ser-OH The acetylated pentapeptide Ac-DRLDS inhibits tumor cell adhesion to laminin, fibronectin, vitronectin, and RGDS-IgG substrates. Ac-DRLDS also inhibits tumor cell adhesion to CS-1-IgG as well as the CS-1-derived peptide (EILDV) (H-2592), in a concentration-dependent manner. Although the inhibitory effect was less than that of EILDV, this peptide retains the properties of both RGDS and EILDV.
GA20438 5-FAM-LL-37 FAM-labeled (ab/em = 494/518nm) LL-37. LL-37 is an antimicrobial peptide with angiogenic activity. It corresponds to the C-terminal sequence (134-170) of the human cathelicidin antimicrobial protein hCAP18/LL-37. hCAP18/LL-37 is an effector of the innate immune system and is expressed in leukocytes and epithelial cells where it is upregulated in association with inflammation and injury. An overexpression of hCAP18/LL-37 in a series of breast carcinomas could be demonstrated. LL-37 has been suggested to stimulate epithelial cell proliferation partially through formyl peptide receptor-like 1 (FPRL1).
GA20284 (Pyr³)-Amyloid β-Protein (3-42)
(PYR3)-淀粉Β-蛋白
(Pyr³)-Amyloid β-Protein (3-42) was found to be the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. Therefore, (Pyr³)-Aβ (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits. Nussbaum et al. studies the Prion-like behaviour and tau-dependent cytotoxicity of the truncated Aβ sequence.
GA20255 (Met¹⁸⁶)-Melanocyte Protein PMEL 17 (185-193) (human, bovine, mouse)
L-异亮氨酰-L-蛋氨酰-L-ALPHA-天冬氨酰-L-谷氨酰胺酰-L-缬氨酰-L-脯氨酰-L-苯丙氨酰-L-丝氨酰-L-缬氨酸
This modified sequence of the gp100 epitope gp(209-217) (H-4106), in which a methionine replaced the natural threonine at position 2, bound to the HLA-A2 molecule with greater affinity than the unmodified peptide and was shown to have an increased ability to generate melanoma-reactive cytotoxic T lymphocytes (CTLs) in vitro when used for sensitization of peripheral blood mononuclear cells. This synthetic peptide hold promise for the development of novel cancer immunotherapies.
GA20223 (Hyp⁴⁷⁴·⁴⁷⁷,Gln⁴⁷⁹)-cyclo-α-Fetoprotein (471-479) (human, lowland gorilla) The cyclic α-fetoprotein-derived peptide analog efficiently inhibited the growth of estrogen-dependent MCF-7 human breast cancer cell xenografts. The extent of inhibition was similar to that of tamoxifen. In contrast to tamoxifen the peptide did not interfere with estrogen binding to its receptor and therefore further development of this compound might yield a new class of valuable agents for the effective treatment of breast cancer.
GA20193 (Glu⁸·⁹)-Helodermin
(Glu⁸·⁹)-Helodermin has been isolated from the salivary gland of the Gila monster Heloderma suspectum. It consists of 35 amino acids and shares 53 and 42% homology with human pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP), respectively. It was shown to have high affinity for the mammalian VIP₂ receptor and equal potency and efficacy for stimulating cAMP production compared with mammalian VIP and PACAP. Even a helodermin-preferring receptor has been described. Furthermore, immunohistochemical studies, using antibodies that did not cross-react with mammalian VIP or PACAP or other known members of the GLP-1 / VIP / PACAP peptide family suggested the existence of a mammalian homologue to (Glu⁸·⁹)-Helodermin distinct from VIP and PACAP.
GA20189 (Glu²)-TRH Fertilization-promoting peptide (FPP), a TRH analog, was previously purified and characterized from both rabbit prostate and human semen. Nanomolar concentrations of this peptide have been shown to enhance capacitation of mouse epididymal spermatozoa with a concomitant increase in fertilizing ability. It was also detected in the thyroid gland. According to a study of Nguyen et al. Pyr-Glu-Pro-NH? opposes the cholinergic effect of TRH in the mammalian CNS: Co-perfusion with an equivalent of TRH in the rat hippocampus resulted in a significant attenuation of TRH-induced acetylcholine release.
GA20185 (Gln⁵³)-Connexin 37 (51-58) (human, mouse, rat) MUT 1, a tumor-associated antigen peptide originally isolated from the mouse Lewis lung carcinoma, appears to be a fragment of the gap junction protein connexin 37, mutated at position 54. MUT 1 induces effective antitumor cytotoxic T lymphocytes and mediates protection against metastasis, as well as rejection of established metastasis. This is the first description of peptide vaccine efficacity in treatment of residual tumors.
GA20030 (Arg⁶)-Amyloid β-Protein (1-40) The English (H6R) mutation of β-amyloid peptides accelerates fibrillation without increasing protofibril formation. Ono et al. showed that the English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers. The exchange of His? by Arg influences the structure of the Cu(II) complex formed by Aβ peptides.
GA20024 (7-Diethylaminocoumarin-3-yl)carbonyl-Amyloid β-Protein (1-40) Amyloid β-protein (1-40) that is N-terminally modified with the fluorescent dye (7-diethylaminocoumarin-3-yl)carbonyl (DAC or DEAC). This derivative can be utilized to assess the binding properties of amyloid β-protein (1-40) for various membranes since it behaves very similar to the native peptide. In aqueous environments the fluorophore is almost non-fluorescent whereas binding to membranes results in an increase in fluorescence intensity (Λex = 430 nm, Λem = 470 nm). Increases in the GM1 ganglioside and cholesterol content in the lipid bilayers facilitated the binding of this peptide. For phosphatidylcholine and phosphatidylserine no affinity was observed.
GC43644 Exendin-4 (acetate)
醋酸艾塞那肽; Exenatide acetate
A GLP-1R agonist
GC31334 Lixisenatide
利西拉来
Lixisenatide (Lyxumia, Adlyxin, ZP10A peptide, AVE0010) is a once-daily short-acting glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-1RA) with an IC50 of 1.4 nM for the human GLP-1 receptor in receptor binding studies.
GC92167 CCZ01048 (trifluoroacetate salt)
DOTA-(Pip)-Nle-CycMSH_hex
CCZ01048 is a synthetic peptide composed of a cyclized fragment of α-melanocyte stimulating hormone (α-MSH) conjugated to the bifunctional chelator DOTA.
GC92166 DOTA-NOC (acetate) DOTA-NOC is a synthetic peptide composed of a derivative of the somatostatin receptor (SST) agonist octreotide conjugated to the bifunctional chelator DOTA.
GC76606 mSIRK mSIRK (G-Protein βγ Binding Peptide) 是一种细胞渗透性 ERK1/2 的激活剂，EC50 为 2.5-5 μM 。mSIRK 会破坏 α 和 βγ 亚基之间的相互作用并促进 α 亚基解离，而不刺激核苷酸交换。
GC76596 C5a Receptor agonist, W5Cha C5a Receptor agonist, W5Cha (Peptide 1) 是一种选择性补体 C5a 受体 (C5aR) 激动剂 (EC50=0.2 μM)，从 C5a 的 C 端衍生而来的六肽，具有特定的氨基酸修饰。C5a Receptor agonist, W5Cha 能够通过其 C 末端精氨酸与 C5a 受体的 Arg-206 位点相互作用，从而激活受体。
GC76448 PACAP (1-38) free acid PACAP (1-38) free acid 是一种内源性神经肽。PACAP (1-38) free acid 能有效地刺激胃窦运动和体液蛋白的分泌，抑制胃泌素的分泌，并刺激血管活性肠肽 (vasoactive intestinal polypeptide)、胃泌素释放肽 (gastrin releasing peptide) 和 P 物质(substance P) 的释放。PACAP (1-38) free acid 还可通过 RACK1 增强 N-甲基-D-天门冬氨酸受体功能和脑源性神经营养因子的表达。
GC91871 Tirzepatide (sodium salt)
LY3298176
Tirzepatide is an agonist of glucagon-like peptide 1 receptor (GLP-1R) and gastric inhibitory polypeptide (GIP) receptor.
GC91869 Retatrutide (sodium salt)
LY3437943
Retatrutide is a triple agonist of the glucagon receptor (GCGR), glucagon-like peptide 1 receptor (GLP-1R), and gastric inhibitory polypeptide receptor (GIP receptor), also known as the glucose-dependent insulinotropic polypeptide receptor.
GC91867 SNX-482 (ammonium salt) SNX-482 is a peptide originally isolated from H. gigas venom that acts as a class E/R-type voltage-sensitive calcium channel blocker (IC50 = 30 nM in 192C cells expressing human class E channels).
GC91866 Apelin-36 (trifluoroacetate salt) The apelin gene encodes a preproprotein that is processed to generate a variety of bioactive peptides, including those having 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively).
GC91865 WaTx (36-68) (scorpion) (trifluoroacetate salt)
Wasabi Receptor Toxin (36-68)
Wasabi receptor toxin (WaTx) (36-68) is a cell-penetrating peptide that corresponds to the mature toxin sequence and is an activator of transient receptor potential ankyrin 1 (TRPA1).
GC91859 LL-37 (13-37) (human) (trifluoroacetate salt)
CAP-18,hCAP-18,Cathelicidin,FALL-39,IG-25,LL-13,LL-25
LL-37 (13-37) is an anticancer peptide fragment of LL-37 .
GC91858 [Ala1,3,11,15]-Endothelin-1 (trifluoroacetate salt)
4-Ala-ET-1,Ala1,3,11,15-ET-1
[Ala1,3,11,15]-Endothelin-1 is an endothelin receptor type B (ETB) agonist and linear synthetic peptide derivative of endothelin-1 in which all four cysteine residues have been substituted with alanine.
GC91855 M40 (trifluoroacetate salt)
Galanin-(1-12)-Pro3-(Ala-Leu)2-Ala amide
M40 is a chimeric galanin-derived peptide and galanin-1 (GAL1) receptor antagonist and GAL2 receptor agonist (Kis = 2.4 and 4.07 nM, respectively).
GC91851 Malantide (trifluoroacetate salt) Malantide is a synthetic peptide derived from the β-subunit of human phosphorylase kinase and is a fluorescent substrate for PKA and PKC.
GC91850 MDM2 (32-46) (trifluoroacetate salt) MDM2 (32-46) is a peptide fragment of MDM2.
GC91848 CH 275 (acetate) CH 275 is a cyclic peptide agonist of somatostatin receptor 1 (SST1; IC50 = 30.9 nM for the human receptor).
GC91846 Mastoparan 7 (trifluoroacetate salt)
Mas7
Mastoparan 7 is a G protein activator and derivative of the mast cell degranulating peptide mastoparan.
GC91840 HBP08 (trifluoroacetate salt) HBP08 is a peptide inhibitor of the protein-protein interaction between chemokine (C-X-C motif) ligand 12 (CXCL12) and high mobility group protein B1 (HMGB1).
GC91836 [Asp371]-Tyrosinase (369-377) (human) (trifluoroacetate salt)
Asp370-Tyrosinase (368-376),Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val
[Asp371]-Tyrosinase (369-377) is a naturally occurring tyrosinase antigen peptide.
GC91826 HCKFWW (trifluoroacetate salt)
His-Cys-Lys-Phe-Trp-Trp-OH,HW6
HCKFWW is a thiol-containing peptide and form of the HIV-1 integrase inhibitor HCKFWW-NH2.
GC91825 Bradykinin (2-9) (trifluoroacetate salt)
BK (2-9),(Des-Arg1)-BK,(Des-Arg1)-Bradykinin,H-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
Bradykinin (2-9) is a metabolite of the endogenous vasodilator peptide bradykinin.
GC91810 PE 22-28 (acetate)
Gly-Val-Ser-Trp-Gly-Leu-Arg-OH
PE 22-28 is a peptide inhibitor of the two-pore domain potassium channel K2P2.1/TREK1 (IC50 = 0.1 nM in HEK293 cells expressing the human channel) and a fragment of spadin .
GC91788 Acetyl Tetrapeptide-3 (acetate) Acetyl tetrapeptide-3 is a biomimetic peptide.
GC91679 Mechercharmycin A
IB-01211
Mechercharmycin A is a cyclic peptide originally isolated from Thermoactinomyces that has anticancer activity.
GC91627 Semaglutide (sodium salt) Semaglutide is an agonist of glucagon-like peptide 1 receptor (GLP-1R; EC50 = 6.2 pM in a reporter assay using BHK cells expressing the human receptor).
GC91626 N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys (trifluoroacetate salt)
fNLFNYK
N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys (fNLFNYK) is a synthetic chemotactic peptide.
GC91615 AZD 5462 AZD 5462 is an agonist of relaxin family peptide receptor 1 (RXFP1).
GC91544 Fmoc-L-Lys[Oct-(OtBu)-Glu-(OtBu)-AEEA-AEEA]-OH
Fmoc-Lys(tBuOCO-(CH2)16-CO-Glu(AEEA-AEEA)-OtBu)-OH
Fmoc-L-Lys[Oct-(OtBu)-Glu-(OtBu)-AEEA-AEEA]-OH is a building block in the synthesis of the glucagon-like peptide 1 receptor (GLP-1R) agonist semaglutide .
GC91538 Fexapotide (trifluoroacetate)
NX-1207
Fexapotide (trifluoroacetate) is a peptide.
GC26379 MAL-PEG-MAL (MW 20000 Da)
马来酰亚胺 PEG 马来酰亚胺, Maleimide PEG Maleimide

Maleimide functionalized polyethylene glycol, Maleimide PEG is a sulfhydryl (thiol/SH) group reactive PEG derivative that can be used to selectively modify protein, peptide or any other surfaces with availablesulfhydryl groups. The reaction between maleimide and thiol proceeds readily at pH 6.5~7.5 to form stable thioether bonds.
GC26216 4-Arm PEG Acrylate
4arm-PEG-ACLT; 4arm-PEG-Acrylate; 四臂 PEG 丙烯酸酯

4 arm PEG derivatives have multiple reactive groups that can be used to modify proteins, peptides and other materials via their functional groups.

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