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Home >> Signaling Pathways >> GPCR/G protein

GPCR/G protein(G 蛋白偶联受体/G 蛋白)

Cat.No. 产品名称 Information
GC14033 ICI 118,551 hydrochloride
ICI 118551 hydrochloride
A potent, selective β₂-adrenergic receptor antagonist
GC11637 Mifepristone
米非司酮; RU486; RU 38486
Mifepristone (RU486）是一种口服有效的孕酮（PR）受体和糖皮质激素受体（GR）拮抗剂，用作堕胎药物，体外实验中IC₅₀值分别为0.2nM和2.6nM。
GC11897 Budesonide
布地奈德
A glucocorticoid and an agonist of glucocorticoid receptors
GC17465 Beclomethasone dipropionate
丙酸倍氯米松
Corticosteroid used for asthma and rhinitis
GC10936 Betamethasone
倍他米松
A synthetic corticosteroid
GC16819 VU0152100
3-氨基-N-[(4-甲氧基苯基)甲基]-4,6-二甲基噻吩并[2,3-B]吡啶-2-甲酰胺,VU152100
A muscarinic M₄ receptor positive allosteric modulator
GC11006 Montelukast Sodium
孟鲁司特钠; MK0476
A CysLT₁ receptor antagonist
GC10664 Org 27569
ORG275695-氯-3-乙基-N-[2-[4-(1-哌啶基)苯基]乙基-1H-吲哚-2-甲酰胺
Org 27569 是一种有效的 CB1 受体变构调节剂，可增加激动剂的结合，但阻断激动剂诱导的 CB1 信号传导。
GC17130 BRL-54443
3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇
A potent agonist of 5-HT_1E and 5-HT_1F
GC17184 Ambrisentan
安倍生坦; BSF 208075; LU 208075
An ET_A receptor antagonist
GC10621 Biperiden HCl
盐酸比哌立登; KL 373 hydrochloride

A muscarinic acetylcholine receptor antagonist
GC11978 CGS 21680 HCl CGS 21680 HCl是一种选择性腺苷A_2A受体激动剂，IC₅₀值为22nM。
GC16226 BRL-15572 dihydrochloride
BRL15572盐酸盐
A 5-HT_1D receptor antagonist
GC11078 MRS 2578 A selective antagonist of the purinergic P2Y₆ receptor
GC17769 Sitaxentan sodium
西他生坦钠,IPI 1040 sodium; TBC11251 sodium
Sitaxentan sodium是一种选择性内皮素A受体（ETA）拮抗剂（IC₅₀ = 1.4nM；K_i = 0.43nM）。
GC10609 GSK962040 hydrochloride
GSK962040 hydrochloride
GSK962040 hydrochloride (GSK962040 hydrochloride) 是一种小分子选择性胃动素受体激动剂，pEC50 为 7.9。
GC16491 GSK962040
GSK962040
GSK962040 (GSK962040) 是一种小分子选择性胃动素受体激动剂，pEC50 为 7.9。
GC17807 TCS 1102 A dual orexin receptor antagonist
GC13539 SB-334867
SB 334867A
An orexin 1 receptor antagonist
GC15653 PF-05212384 (PKI-587)
N-[4-[[4-(二甲基氨基)-1-哌啶基]羰基]苯基]-N'-[4-[4,6-二(4-吗啉基)-1,3,5-三嗪-2-基]苯基]脲,PKI-587; PF-05212384
A potent, dual PI3K/mTOR inhibitor
GC17414 Palosuran
ACT-058362
A urotensin II receptor antagonist
GC16394 PD123319
(S)-(+)-PD 123319
PD123319 是血管紧张素 II 受体的非肽类抑制剂，IC50 值为 34nM 。
GC15332 Ticagrelor
替卡格雷; AZD6140; AR-C 126532XX
A reversible purinergic P2Y₁₂ receptor antagonist
GC16943 NPS-2143
2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈,SB-262470A
NPS-2143 是一种钙化药物，可作为钙敏感受体 (CaSR) 的拮抗剂，从而刺激甲状旁腺激素的释放。
GC10264 Arecoline hydrobromide
氢溴酸槟榔碱
Muscarinic acetylcholine receptor agonist
GC12073 Xylazine
赛拉嗪,BAY 1470

Xylazine（赛拉嗪；BAY 1470）是一种有效的α2-肾上腺素受体的强激动剂，在兽医学中广泛用作镇静剂，还能诱导肌肉松弛。
GC15631 Sotalol hydrochloride
盐酸索他洛尔; MJ 1999
A β-AR antagonist and a class III antiarrhythmic agent
GC13085 Terazosin
特拉唑嗪
A potent and selective α₁-AR antagonist
GC10698 Cyproheptadine hydrochloride
盐酸赛庚啶
An antihistamine with antiserotonergic and anticholinergic activities
GC13236 ACT-132577
N-[5-(4-溴苯基)-6-[2-[(5-溴-2-嘧啶基)氧基]乙氧基]-4-嘧啶基]氨基磺酰胺,ACT-132577
A dual ET_A and ET_B receptor antagonist and an active metabolite of macitentan
GC15916 BQ-788 sodium salt
BQ-788钠盐
A peptide ET_B receptor antagonist
GC14944 AR 231453 An agonist of GPR119
GC11939 AMG 487
(±)-AMG 487

A CXCR3 antagonist
GC15222 Siramesine hydrochloride
西拉美新盐酸盐; Lu 28-179 hydrochloride
Siramesine hydrochloride是一种有效的sigma-2受体激动剂。Siramesine对sigma-2受体具有亚纳摩尔亲和力 (IC₅₀=0.12nM)，并且对sigma-2受体的选择性是sigma-1受体的140倍(IC₅₀=17nM)。
GC10050 Almorexant hydrochloride
阿莫伦特盐酸盐,ACT 078573 hydrochloride
An orexin 1 and orexin 2 receptor antagonist
GC10717 Almorexant
阿莫伦特; ACT 078573
Almorexant (ACT 078573) 是一种具有口服活性、强效和竞争性的双重食欲素受体拮抗剂，Kd 值分别为 1.3 nM (OX1) 和 0.17 nM (OX2)。
GC16701 SKI II
鞘氨醇激酶抑制剂
An SPHK1 inhibitor
GC10030 EHop-016 A Rac1 and Rac3 inhibitor
GC17201 BAF312 (Siponimod)
辛波莫德; BAF-312
An S1P₁ and S1P₅ receptor agonist receptor modulator
GC14807 Fingolimod (FTY720) HCl
盐酸芬戈莫德; FTY720
芬戈莫德(FTY720)是一种免疫抑制剂,通常用于治疗多发性硬化症,也有抗癌作用,可以作为HDACi(组蛋白脱乙酰酶抑制剂)。
GC12611 Triamcinolone Acetonide
曲安奈德
A synthetic corticosteroid
GC11915 Mirabegron (YM178)
米拉贝隆; YM178
A β3-AR agonist
GC12717 Ipratropium Bromide
异丙托溴铵; Sch 1000
A muscarinic receptor antagonist
GC13871 Duloxetine HCl
盐酸度洛西汀; (S)-Duloxetine hydrochloride; LY-248686 hydrochloride
A serotonin and norepinephrine reuptake inhibitor
GC16635 Diphemanil Methylsulfate
甲硫二苯马尼,Diphemanil mesylate
An anticholinergic agent
GC12627 Conivaptan HCl
盐酸考尼伐坦; YM 087
A vasopressin V_1A and V₂ receptor antagonist
GC13638 Betamethasone Valerate
倍他米松戊酸酯,Betamethasone 17-valerate
A glucocorticoid with anti-inflammatory activity
GC12122 Betamethasone Dipropionate
二丙酸倍他米松; Betamethasone 17,21-dipropionate
倍他米松二丙酸酯是一种糖皮质激素类固醇，具有抗炎和免疫抑制能力。
GC14160 Blonanserin
布南色林; AD-5423
A dopamine and serotonin receptor antagonist
GC11977 Thioridazine HCl
盐酸硫利达嗪；盐酸硫代利哒；甲硫达嗪盐酸盐；甲硫哒嗪盐酸盐
A typical antipsychotic