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Home >> Signaling Pathways >> GPCR/G protein >> Melatonin Receptors

Melatonin Receptors(褪黑激素受体)

Melatonin Receptor is a G protein-coupled receptor (GPCR) which binds melatonin. Three types of melatonin receptor have been cloned. The MT1 and MT2 receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MT3 has been identified in amphibia and birds. The MT1 subtype's expression in the pars tuberalis of the pituitary gland and suprachiamatic nuclei of the hypothalamus is indicative of melatonin's circadian and reproductive functional involvement. The MT2 subtype's expression in the retina is suggestive of melatonin's effect on the mammalian retina occurring through this receptor. Research suggests that melatonin acts to inhibit the Ca2+-dependent release of dopamine. Melatonin's action in the retina is believed to affect several light-dependent functions, including phagocytosis and photopigment disc shedding.

Products for  Melatonin Receptors

  1. Cat.No. 产品名称 Information
  2. GC69448 Melatonin-d3

    N-Acetyl-5-methoxytryptamine-d3

    Melatonin-d3 是 Melatonin 的氘代物。Melatonin 是一种由松果体制成的激素，可激活褪黑激素受体。Melatonin 在睡眠中起作用并具有重要的抗氧化和抗炎特性。Melatonin 是一种新型的选择性 ATF-6 抑制剂，可通过 COX-2 下调诱导人肝癌细胞凋亡。Melatonin 通过内质网应激减弱palmitic acid-induced 诱导的小鼠颗粒细胞凋亡。
  3. GC68331 Ramelteon metabolite M-II-d3 Ramelteon metabolite M-II-d3 是 Ramelteon metabolite M-II 的氘代物。Ramelteon metabolite M-II 是雷美替胺 (Ramelteon) 的主要代谢物，其对人褪黑素受体 1 和 2 的 IC50 值分别为 208 pM 和 1470 pM。雷美替胺是褪黑素受体 (melatonin) 的选择性激动剂。
  4. GC64204 S-22153 S-22153 是一种有效的褪黑素受体 (melatonin receptor) 拮抗剂，对 hMT1 和 hMT2 的 EC50 值分别为 19 nM 和 4.6 nM。S-22153 对 hMT1 的 Ki 值为 8.6 nM (CHO 细胞) 和 16.3 nM (HEK 细胞)，hMT2 的 Ki 值为 6.0 nM (CHO 细胞) 和 8.2 nM (HEK 细胞)。S-22153 是 MT1 和 MT2 褪黑素受体亚型的特异性配体。
  5. GC62825 ACH-000143 ACH-000143 是有效的、具有口服活性的褪黑素受体的激动剂，对MT1 和MT2 的EC50 值分别为0.06 nM 和0.32 nM。
  6. GC60241 Melatonin D5

    褪黑素 D5; N-Acetyl-5-methoxytryptamine-d4

     An internal standard for the quantification of melatonin
  7. GC38844 S26131 S26131 (compound 5) 是一种高效、选择性的 MT1 褪黑激素配体。对 MT1 和 MT2 的 Ki 值分别为 0.5 和 112 nM。S26131 表现为 MT1 和 MT2 拮抗剂。
  8. GC37070 Ramelteon metabolite M-II

    雷美替胺杂质

     A mixed isomer preparation of ramelteon metabolite M-II
  9. GC35270 Agomelatine L(+)-Tartaric acid

    阿戈美拉汀 L(+)-酒石酸; S-20098 L(+)-Tartaric acid

     Agomelatine（L(+)-酒石酸）可抗抑郁，是一种去甲肾上腺素-多巴胺抑制解除剂（NDDI），能拮抗5-HT2C受体。
  10. GC35269 Agomelatine hydrochloride

    维度新; S-20098 hydrochloride

     A melatonin receptor agonist and 5-HT2B and 5-HT2C antagonist
  11. GC30781 Tasimelteon (BMS-214778)

    他司美琼; BMS-214778; VEC-162

    A melatonin receptor agonist
  12. GC15365 N-Acetylserotonin

    N-乙酰-5-羟色胺,N-Acetyl-5-hydroxytryptamine,NAS

     The immediate precursor of melatonin
  13. GC14728 DH 97 An MT2 receptor antagonist
  14. GC16020 8-M-PDOT

    AH-002

     An MT2 receptor agonist
  15. GC16186 4-P-PDOT

    AH 024

     An antagonist of the MT2 receptor
  16. GC11188 GR 135531

    N-甲氧基羰基琥珀酰亚胺,5-METHOXYCARBONYLAMINO-N-ACETYLTRYPTAMINE

     MT3 receptor agonist
  17. GC17898 Luzindole

    N-乙酰-2-苄基色胺,N-0774

     A melatonin receptor antagonist
  18. GC14690 2-Iodomelatonin

    2-碘褪黑激素

     A potent MT1 receptor agonist
  19. GC11288 2-Phenylmelatonin

    2-Phenylmelatonin

     A MT receptor mixed partial agonist and antagonist
  20. GC12014 6-Chloromelatonin

    6-羟基褪黑素

    6-Chloromelatonin 是一种有效的褪黑激素受体激动剂，具有比褪黑激素更高的代谢稳定性。
  21. GC13047 N-Acetyltryptamine

    N-乙酰基色胺,N10-Acetyltryptamine; Nb-Acetyltryptamine; Nω-Acetyltryptamine

     A melatonin analog
  22. GC17981 Agomelatine

    阿戈美拉汀; S-20098

     Agomelatine是一种褪黑素（MT）受体激动剂，对MT1和MT2的Ki值分别为0.1 nM和0.12 nM。Agomelatine也是一种5-羟色胺（5-HT）受体拮抗剂，对5-HT2C 和5-HT2B 的Ki值分别为631 nM和660 nM。
  23. GC15053 Ramelteon

    雷美替胺; TAK-375

     A melatonin receptor agonist
  24. GC15618 Melatonin

    褪黑素; N-Acetyl-5-methoxytryptamine

    An indoleamine neurohormone that entrains circadian rhythms

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