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Melatonin Receptors

Melatonin Receptor is a G protein-coupled receptor (GPCR) which binds melatonin. Three types of melatonin receptor have been cloned. The MT1 and MT2 receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MT3 has been identified in amphibia and birds. The MT1 subtype's expression in the pars tuberalis of the pituitary gland and suprachiamatic nuclei of the hypothalamus is indicative of melatonin's circadian and reproductive functional involvement. The MT2 subtype's expression in the retina is suggestive of melatonin's effect on the mammalian retina occurring through this receptor. Research suggests that melatonin acts to inhibit the Ca2+-dependent release of dopamine. Melatonin's action in the retina is believed to affect several light-dependent functions, including phagocytosis and photopigment disc shedding.

  1. Cat.No. Product Name Information
  2. GC14690 2-Iodomelatonin melatonin agonist
  3. GC11288 2-Phenylmelatonin melatonin agonist
  4. GC16186 4-P-PDOT

    Melatonin receptor antagonist

  5. GC12014 6-Chloromelatonin melatonin agonist
  6. GC16020 8-M-PDOT Melatonin receptor agonist
  7. GC17981 Agomelatine MT1/MT2 / 5-HT2C agonist
  8. GC35269 Agomelatine hydrochloride Agomelatine盐酸盐是人和猪的5-HT2C受体拮抗剂,pKi分别为6.2和6.4,同时对人5-HT2B受体的pKi为6.6。
  9. GC35270 Agomelatine L(+)-Tartaric acid Agomelatine(L(+)-酒石酸)可抗抑郁,是一种去甲肾上腺素-多巴胺抑制解除剂(NDDI),能拮抗5-HT2C受体。
  10. GC14728 DH 97 MT2 melatonin receptor antagonist
  11. GC11188 GR 135531 MT3 receptor agonist
  12. GC17898 Luzindole

    Melatonin antagonist

  13. GC15618 Melatonin Melatonin receptors agonist
  14. GC60241 Melatonin D5 Melatonin D5 是Melatonin 的氘代物。Melatonin是一种由松果体制成的激素,可激活褪黑激素受体 (melatonin receptor)。具有抗氧化和抗炎特性。Melatonin 是一种新型的选择性 ATF-6 抑制剂,可通过 COX-2 下调诱导人肝癌细胞凋亡。
  15. GC15365 N-Acetylserotonin an agonist at the melatonin receptors MT1, MT2, and MT3
  16. GC13047 N-Acetyltryptamine melatonin receptor modulator
  17. GC15053 Ramelteon Agonist of melatonin receptor(M1-M2),highly selective
  18. GC37070 Ramelteon metabolite M-II Ramelteon metabolite M-II 是雷美替胺 (Ramelteon) 的主要代谢物,其对人褪黑素受体 1 和 2 的 IC50 值分别为 208 pM 和 1470 pM。雷美替胺是褪黑素受体 (melatonin) 的选择性激动剂。
  19. GC38844 S26131 S26131 (compound 5) 是一种高效、选择性的 MT1 褪黑激素配体。对 MT1 和 MT2 的 Ki 值分别为 0.5 和 112 nM。S26131 表现为 MT1 和 MT2 拮抗剂。
  20. GC30781 Tasimelteon (BMS-214778) Tasimelteon是褪黑素MT1和MT2受体激动剂。

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