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5-HT Receptor(5-羟色胺受体)

5-HT receptor (5-hydroxytryptamine receptors) is a group of GPCRs (G protein-coupled receptors) and LGICs (ligand-gated ion channels) found in the central and peripheral nervous systems.

  1. Cat.No. 产品名称 Information
  2. GC26002 Trazodone Trazodone (AF-1161) is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders.
  3. GC25898 SB 200646 SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.
  4. GC25756 Pirenperone Pirenperone (R-47456, R-50656), a quinazoline derivative, is a selective antagonist of SR-2A (5-HT2 serotonin receptor) when employed in low doses. Pirenperone behaves like a typical neuroleptic when used in higher doses (greater than 0.1 mg/kg).
  5. GC25569 Lerisetron Lerisetron (F 0930, F 0930RS) is a 5-HT3 receptor antagonist with IC50 of 0.81μM.
  6. GC25563 Lasmiditan succinate Lasmiditan succinate (COL-144, LY573144) is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (Ki=2.21 nM) without vasoconstrictor activity.
  7. GC25434 Frovatriptan Succinate Frovatriptan Succinate(SB 209509 Succinate,VML 251 Succinate) is the succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT) receptor agonist activity especially for the 5-HT1B/1D receptors.
  8. GC25259 Cisapride hydrate Cisapride (Propulsid, Alimix, Propulsin, Enteropride, Kinestase) acts directly as a selective serotonin 5-HT4 receptor agonist with IC50 of 0.483 μM. And It also acts indirectly as a parasympathomimetic.
  9. GC25253 Cinitapride Hydrogen Tartrate Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors
  10. GC67989 (S)-Mirtazapine
  11. GC67937 (R)-Mirtazapine
  12. GC67923 Renzapride
  13. GC65983 5-HT3 antagonist 5
  14. GC65568 5-HT2B antagonist-1 WAY-388264-A is a bioactive compound.
  15. GC65565 Cyproheptadine Cyproheptadine HCl(Periactin) is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist.
  16. GC65296 Pimethixene maleate Pimethixene (Pimetixene) maleate, an antihistamine, anntimigraine agent and antiserotonergic compound, is a highly potent antagonist of a broad range of monoamine receptors, including a variety of serotonin receptors. Pimethixene maleate inhibits 5-HT2A, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1B, 5-HT6, 5-HT7, Adrenergic α-1A, Dopamine D1 Receptor, Dopamine D2 Receptor, Dopamine D4.4 Receptor, Histamine H1 Receptor, Muscarinic M1 and Muscarinic M2 with pKi of 10.22, 10.44, 8.42, 7.63, < 5, 7.30, 7.28, 7.61, 6.37, 8.19, 7.54, 10.14, 8.61 and 9.38, respectively.
  17. GC65265 UNC9994 hydrochloride
  18. GC65014 DSP-1053
  19. GC64660 Usmarapride free base
  20. GC64606 Ro60-0175 A 5-HT2 receptor agonist
  21. GC64563 α-Methylserotonin
  22. GC64530 Sarizotan
  23. GC64423 Repinotan hydrochloride
  24. GC64265 Alosetron-13C,d3
  25. GC64182 5-Methoxytryptamine hydrochloride
  26. GC64080 Usmarapride
  27. GC63961 Cerlapirdine
  28. GC63842 Rodatristat
  29. GC63819 Asenapine maleate Asenapine maleate (Org 5222) is a high-affinity antagonist of serotonin, norepinephrine, dopamine and histamine receptors, used for the treatment of schizophrenia and acute mania associated with bipolar disorder.
  30. GC63682 Felcisetrag
  31. GC63632 (Rac)-Lorcaserin
  32. GC63599 Bufotenidine
  33. GC63432 Sertindole-d4
  34. GC63382 (Rac)-Lorcaserin hydrochloride
  35. GC63252 Velusetrag hydrochloride
  36. GC63251 Velusetrag
  37. GC63188 Serotonin Serotonin HCl (5-HT) is a monoamine neurotransmitter and Endogenous 5-HT receptor agonist.
  38. GC63169 Relenopride hydrochloride
  39. GC63111 NLX-204 hydrochloride NLX-204 is a potent, selective agonist of ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor with pKi of 10.19.
  40. GC63015 Iferanserin
  41. GC62967 F13714 fumarate
  42. GC62932 Didesmethyl cariprazine
  43. GC62799 4,4-Diphenylbutylamine hydrochloride
  44. GC62458 Rodatristat ethyl
  45. GC62417 Alniditan dihydrochloride
  46. GC61889 OPC-14523 hydrochloride
  47. GC61809 Olanzapine D3
  48. GC61742 Strictosidinic acid
  49. GC61565 Indophagolin Indophagolin, a potent indoline-containing autophagy inhibitor with IC50 of 140 nM, antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively, also has a strong antagonistic effect on serotonin receptor 5-HT6 with IC50 of 1.0 μM.
  50. GC61464 GR 125743
  51. GC61401 Oxatomide

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