5-HT Receptor(5-羟色胺受体)
5-HT receptor (5-hydroxytryptamine receptors) is a group of GPCRs (G protein-coupled receptors) and LGICs (ligand-gated ion channels) found in the central and peripheral nervous systems.
Products for 5-HT Receptor
- Cat.No. 产品名称 Information
- GC38828 Org-12962 A 5-HT2C receptor agonist
- GC38781 Frovatriptan succinate hydrate An agonist of 5-HT1B and 5-HT1D receptors
- GC38760 Cyamemazine Cyamemazine 是一种抗精神病药,其中含有吩噻嗪发色团,通常被用作抗焦虑药。Cyamemazine 是具有抗精神病活性的有效的 5-HT3 (Ki 为 12 nM), 5-HT2A (Ki 为 1.5 nM) 和 5-HT2C (Ki 为 75 nM) 受体拮抗剂。
- GC38753 cis-Urocanic acid cis-Urocanic acid 是一种 5-HT2A 受体激动剂。cis-Urocanic acid 以较高亲和力与 5-HT 受体结合,Kd 为 4.6 nM。cis-Urocanic acid 是一种免疫调节剂,通过与 5-HT2A 受体结合而诱导免疫抑制。
- GC45791 PF-04995274 A partial 5-HT4 agonist
- GC38529 Geissoschizine methyl ether Geissoschizine methyl ether,一种 Uncaria hook 发现的生物碱类化合物,也是具有精神药物作用的 Yokukansan 的主要活性成分。Geissoschizine methyl ether 是有效的 5-HT1A 受体的激动剂。
- GC38509 Masupirdine mesylate Masupirdine mesylate (SUVN-502 mesylate) 是一种有效的,选择性的,具有口服生物可利用且可穿透脑屏障的 5-HT6 受体拮抗剂 (对人 5-HT6 受体的 Ki 为 2.04 nM)。Masupirdine mesylate (SUVN-502 mesylate) 对 5-HT2A 受体和其他 100个 靶点显示高选择性,有治疗阿尔茨海默病的潜力。
- GC38433 Jatrorrhizine An alkaloid with diverse biological activities
- GC38413 Harmine hydrochloride A unique regulator of PPARγ expression
- GC38227 Gamma-Mangostin A xanthone with diverse biological activities
- GC38108 2-Methyl-5-HT 2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) 是一种有效的选择性 5-HT3 受体激动剂。2-Methyl-5-HT 显示出抗抑郁样作用。
- GC37969 Ziprasidone D8 An internal standard for the quantification of ziprasidone
- GC37906 Vilazodone D8 An internal standard for the quantification of vilazodone
- GC37861 Urapidil An α1-AR antagonist and 5-HT1A receptor partial agonist
- GC37734 Tandospirone citrate Tandospirone (SM-3997), a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM, has anxiolytic and antidepressant activities.
- GC37599 SB-269970 A 5-HT7A and adrenergic α2 receptor antagonist
- GC37597 SB 271046 Hydrochloride An orally-available 5-HT6 antagonist
- GC37596 SB 258719 SB 258719 是一个有选择性的 5-HT7 受体拮抗剂,其 pKi 值为 7.5。
- GC37569 RU 24969 A 5-HT1A and 5-HT1B receptor agonist
- GC37540 Risperidone mesylate An atypical antipsychotic
- GC37539 Risperidone hydrochloride An atypical antipsychotic
- GC37055 Quetiapine D4 fumarate Quetiapine D4富马酸盐是Quetiapine氘代化合物标准品。
- GC36924 Pipamperone Pipamperone (Floropipamide; McN-JR 3345; R 3345) 是 5-HT2A 受体 (pKi=8.2) 和 D4 受体 (pKi=8.0) 的高亲和力拮抗剂。Pipamperone (Floropipamide; McN-JR 3345; R 3345) 是 D2 受体 (pKi=6.7) 的低亲和力拮抗剂。
- GC36919 Pimavanserin tartrate A 5-HT2A inverse agonist
- GC36912 Piboserod hydrochloride Piboserod (SB 207266)盐酸盐是5-羟色胺受体5-HT4选择性抑制剂。
- GC36875 Perphenazine D8 Dihydrochloride Perphenazine D8二盐酸盐是Perphenazine氘代化合物标准品。
- GC36844 Palonosetron Palonosetron (RS25259, RS 25259 197) is a 5-HT3 antagonist with Ki value of 0.17 nM. It is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
- GC36693 Naratriptan D3 Hydrochloride Naratriptan D3盐酸盐是Naratriptan的氘代化合物标准品。
- GC36548 Masupirdine free base Masupirdine free base (SUVN-502 free base) 是一种有效的,选择性的,具有口服生物可利用且可穿透脑屏障的5-HT6 受体拮抗剂 (对人 5-HT6 受体的 Ki 为 2.04 nM)。Masupirdine free base (SUVN-502 free base) 对 5-HT2A 受体和其他 100个 靶点显示高选择性,有治疗阿尔茨海默病的潜力。
- GC36511 LY334370 A 5-HT1F receptor agonist
- GC36503 LY 344864 S-enantiomer LY 344864 S-enantiomer 是 LY344864 的 S 型对映体。LY344864 是 5-HT1F 受体激动剂。
- GC36502 LY 344864 racemate LY 344864 racemate 是一种 5-HT1F 受体激动剂, 来自专利 US 5708187 A。
- GC36501 LY 344864 hydrochloride A 5-HT1F receptor antagonist
- GC36428 Lasmiditan hydrochloride An Analytical Reference Standard
- GC36291 Idalopirdine A 5-HT6 receptor antagonist
- GC35894 Donitriptan Donitriptan 是一种有效的高亲和力 5-HT1B/1D 受体激动剂,pKi 分别为 9.4 和 9.3。
- GC35610 Cariprazine hydrochloride An atypical antipsychotic
- GC35386 Aripiprazole D8 An internal standard for the quantification of aripiprazole
- GC35303 Alosetron D3 Hydrochloride Alosetron D3 Hydrochloride (GR-68755C D3) 是Alosetron氘代化合物标准品。
- GC35302 Alosetron (Hydrochloride(1:X)) A 5-HT3 receptor antagonist
- GC35301 Alosetron ((Z)-2-butenedioate) Alosetron (Z)-2-butenedioate (GR 68755 (Z)-2-butenedioate) 是5-HT3受体拮抗剂,可作用于肠易激综合征。
- GC35270 Agomelatine L(+)-Tartaric acid Agomelatine(L(+)-酒石酸)可抗抑郁,是一种去甲肾上腺素-多巴胺抑制解除剂(NDDI),能拮抗5-HT2C受体。
- GC35269 Agomelatine hydrochloride A melatonin receptor agonist and 5-HT2B and 5-HT2C antagonist
- GC35252 Adoprazine Adoprazine是5-HT1A受体的完全激动剂和D2/3受体的拮抗剂。
- GC35011 (Z)-Thiothixene (Z)-Thiothixene 是 serotonergic receptor 的拮抗剂,来自专利 US 20150141345 A1。
- GC34995 (R,R)-Palonosetron Hydrochloride (R,R)-Palonosetron Hydrochloride 是一个有活性的 Palonosetron 对映异构体。
- GC45157 WAY-161503 A 5-HT2C receptor agonist
- GC44978 Syk Inhibitor II A selective blocker of spleen tyrosine kinase activity
- GC44875 SB-242084 (hydrochloride) Specific antagonist of 5-HT2C
- GC44259 Myristicin An Analytical Reference Standard