(S)-Mirtazapine-d3
(Synonyms: (S)-Org3770 D3; (S)-6-Azamianserin D3) 目录号 : GC68410(S)-Mirtazapine D3 ((S)-Org3770 D3) 是 (S)-Mirtazapine 氘代物。(S)-Mirtazapine 是 Mirtazapine 的 S(+)-对映异构体，在急性热伤害感受动物模型中具有促伤害感受的特性。(S)-Mirtazapine 是一种立体选择性 5-HT2 受体拮抗剂，在体内被 CYP2D6 和 CYP1A2 代谢。
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
(S)-Mirtazapine D3 ((S)-Org3770 D3) is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception.(S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2[1].
[1]. Muth-Selbach U, et al. Racemic intrathecal mirtazapine but not its enantiomers acts anti-neuropathic after chronic constriction injury in rats. Brain Res Bull. 2009 Apr 6;79(1):63-8.
| Cas No. | SDF | Download SDF | |
| 别名 | (S)-Org3770 D3; (S)-6-Azamianserin D3 | ||
| 分子式 | C17H16D3N3 | 分子量 | 268.37 |
| 溶解度 | 储存条件 | Store at -20°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.7262 mL | 18.631 mL | 37.262 mL |
| 5 mM | 0.7452 mL | 3.7262 mL | 7.4524 mL |
| 10 mM | 0.3726 mL | 1.8631 mL | 3.7262 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Craniometrics and Ventricular Access: A Review of Kocher'S, Kaufman'S, Paine'S, Menovksy'S, Tubbs', Keen'S, Frazier'S, Dandy'S, and Sanchez'S Points
Oper Neurosurg (Hagerstown) 2020 May 1;18(5):461-469.PMID:31420653DOI:10.1093/ons/opz194.
Intraventricular access is frequently required during neurosurgery, and when neuronavigation is unavailable, the neurosurgeon must rely upon craniometrics to achieve successful ventricular cannulation. In this historical review, we summarize the most well-described ventricular access points: Kocher'S, Kaufman'S, Paine'S, Menovksy'S, Tubbs', Keen'S, Frazier'S, Dandy'S, and Sanchez'S. Additionally, we provide multiview, 3-dimensional illustrations that provide the reader with a novel understanding of the craniometrics associated with each point.
Finkelstein'S Test Is Superior to Eichhoff'S Test in the Investigation of de Quervain'S Disease
J Hand Microsurg 2018 Aug;10(2):116-118.PMID:30154628DOI:10.1055/s-0038-1626690.
Introduction de Quervain'S tenosynovitis is a common pathologic condition of the hand. Finkelstein'S test has long been considered to be a pathognomonic sign of this diagnosis, yet most clinicians and instruction manuals erroneously describe what is in fact the Eichhoff'S test, which is thought to produce similar pain by tendon stretching in a normal wrist. The purpose of this study was to compare Finkelstein'S test with Eichhoff'S test in asymptomatic individuals. Materials and Methods Thirty-six asymptomatic participants (72 wrists) were examined using both Finkelstein'S and Eichhoff'S tests with a minimum interval of 24 hours between the tests. Results The results showed that Finkelstein'S test was more accurate than Eichhoff'S test. It demonstrated higher specificity, produced significantly fewer numbers of false-positive results, and also caused significantly less discomfort to patients. Conclusion This study recommends Finkelstein'S test as the clinical examination of choice for the diagnosis of de Quervain'S disease.
Impact of sporadic reporting of poultry Salmonella serovars from selected developing countries
J Infect Dev Ctries 2015 Jan 15;9(1):1-7.PMID:25596565DOI:10.3855/jidc.5065.
This review documents the sporadic reporting of poultry Salmonella serovars in South Africa, Egypt, Indonesia, India, and Romania, five countries selected based on the importance of their distribution in different regions of the world and their cumulative significant population size of 1.6 billion. South Africa reported contamination of its poultry carcasses by S. Hadar, S. Blockley, S. Irumu, and S. Anatum. Results from Egypt showed that S. Enteritidis and S. Typhimurium were predominant in poultry along with other non-typhoid strains, namely S. Infantis, S. Kentucky, S. Tsevie, S. Chiredzi, and S. Heidelberg. In Indonesia, the isolation of Salmonella Typhi was the main focus, while other serovars included S. Kentucky, S. Typhimurium, and S. Paratyhi C. In India, S. Bareilly was predominant compared to S. Enteritidis, S. Typhimurium, S. Paratyphi B, S. Cerro, S. Mbandaka, S. Molade, S. Kottbus, and S. Gallinarum. Romania reported two Salmonella serovars in poultry that affect humans, namely S. Enteritidis and S. Typhimurium, and other non-typhoid strains including S. Infantis, S. Derby, S. Colindale, S. Rissen, S. Ruzizi, S. Virchow, S. Brandenburg, S. Bredeney, S. Muenchen, S. Kortrijk, and S. Calabar. The results showed the spread of different serovars of Salmonella in those five developing countries, which is alarming and emphasizes the urgent need for the World Health Organization Global Foodborne Infections Network (WHO-GFN) to expand its activities to include more strategic participation and partnership with most developing countries in order to protect poultry and humans from the serious health impact of salmonellosis.
Molecular mechanism of the S-RNase-based gametophytic self-incompatibility in fruit trees of Rosaceae
Breed Sci 2016 Jan;66(1):116-21.PMID:27069396DOI:10.1270/jsbbs.66.116.
Self-incompatibility (SI) is a major obstacle for stable fruit production in fruit trees of Rosaceae. SI of Rosaceae is controlled by the S locus on which at least two genes, pistil S and pollen S, are located. The product of the pistil S gene is a polymorphic and extracellular ribonuclease, called S-RNase, while that of the pollen S gene is a protein containing the F-box motif, SFB (S haplotype-specific F-box protein)/SFBB (S locus F-box brothers). Recent studies suggested that SI of Rosaceae includes two different systems, i.e., Prunus of tribe Amygdaleae exhibits a self-recognition system in which its SFB recognizes self-S-RNase, while tribe Pyreae (Pyrus and Malus) shows a non-self-recognition system in which many SFBB proteins are involved in SI, each recognizing subset of non-self-S-RNases. Further biochemical and biological characterization of the S locus genes, as well as other genes required for SI not located at the S locus, will help our understanding of the molecular mechanisms, origin, and evolution of SI of Rosaceae, and may provide the basis for breeding of self-compatible fruit tree cultivars.
A review of the genus Scrobipalpa Janse, 1951 (Lepidoptera, Gelechiidae) in the Afrotropical region
Zootaxa 2021 Nov 19;5070(1):1-83.PMID:34810684DOI:10.11646/zootaxa.5070.1.1.
The genus Scrobipalpa in the Afrotropical region is revised. Thirty-six species are recognized as valid, 20 of which are described as new: S. ochroxantha sp. nov. (South Africa), S. wieseri sp. nov. (Namibia, South Africa), S. turiensis sp. nov. (Kenya), S. wolframi sp. nov. (Namibia), S. natalensis sp. nov. (South Africa), S. varivansoni sp. nov. (South Africa), S. typica sp. nov. (South Africa), S. staudei sp. nov. (South Africa), S. afromontana sp. nov. (Kenya), S. erexita sp. nov. (South Africa), S. admirabilis sp. nov. (Namibia), S. griseata sp. nov. (South Africa), S. nigristriana sp. nov. (Kenya), S. munita sp. nov. (Malawi), S. ochracea sp. nov. (South Africa), S. asantesana sp. nov. (South Africa), S. selectoides sp. nov. (Namibia, RSA), S. etoshensis sp. nov. (Namibia), S. ethiopica sp. nov. (Ethiopia), and S. agassizi sp. nov. (Kenya). Six new synonyms are established: Phthorimaea blapsigona Meyrick, 1916 and Scrobipalpa asiri Povoln, 1980 syn. nov. of Scrobipalpa concreta (Meyrick, 1914); Scrobipalpa xylochroa Janse, 1963 and S. obsoletella hospes Povoln, 1964 syn. nov. of S. obsoletella (Fischer von Rslerstamm, 1841); S. vicaria (Meyrick, 1921) syn. nov. of S. geomicta (Meyrick, 1918); and Gelechia chersophila Meyrick, 1918 syn. nov. of S. portosanctana (Stainton, 1859). The following new combinations for five species previously placed in Scrobipalpa are proposed: Ephysteris cretigena (Meyrick, 1914) comb. nov., Microlechia colasta (Meyrick, 1921) comb. nov., Schizovalva costimacula (Janse, 1951) comb. nov., Gelechia trychnophylla (Janse, 1960) comb. nov. and Trychnopalpa phalacrodes (Meyrick, 1913) comb. nov. Two species, Phthorimaea pendens Meyrick, 1918 comb. rev. and Homaloxestis ocyphanes Meyrick, 1937 comb. rev., are excluded from Scrobipalpa but no current genus is available. The male genitalia of Scrobipalpa nomias (Meyrick, 1921) are described for the first time. All species are diagnosed, some of them are redescribed based on additional material. Identification keys and photographs of adults and genitalia are provided. New or additional host plants are recorded for Scrobipalpa incola (Meyrick, 1912), S. concreta, S. portosanctana, and S. ergasima (Meyrick, 1916). Scrobipalpa incola is recorded for the first time from Namibia, Tanzania, and Kenya; S. concreta is new for Ethiopia, Sudan, Tanzania, Kenya, Mozambique, Benin and Mauritius; S. subroseata for Tanzania and Kenya; S. aptatella (Walker, 1864) and S. biljurshi Povoln, 1980 for Ethiopia; S. obsoletella and S. traganella (Chrtien, 1915) for Namibia; S. geomicta for India and Ethiopia; and S. ergasima for Benin, Zimbabwe, Tanzania, Ethiopia, and Yemen.