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EBI2/GPR183

The Epstein-Barr virus (EBV) induced receptor 2 (EBI2; also known as GPR183) is an orphan member of the 7TM receptor family A. EBI2 is a constitutively active seven-transmembrane receptor. EBI2 has been placed in varying 7TM receptor subgroups by different phylogenetic analyses as being a target of peptide or lipid ligands. EBI2 constitutively activates extracellular signal-regulated kinase (ERK) in a pertussis toxin-insensitive manner. EBI2 is up-regulated up to 200-fold in B cells following EBV infection.

EBI2 activation stimulates immune cell migration and has been genetically linked to autoimmune diseases including type 1 diabetes. Small molecule modulators of EBI2 can be useful for probing the function of the receptor and its relevance to human diseases.

  1. Cat.No. 产品名称 Information
  2. GC65986 SAE-14 SAE-14 (compound SAE-14) 是一种有效、特异的 GPR183 拮抗剂,IC50值为 28.5 nM,可抑制 HL-60 细胞中 7α, 25-OHC 诱导的钙信号转导, IC50 值低于 50 nM。SAE-14 可逆转小鼠的异位性疼痛。
  3. GC38820 ML401 ML401 是一种有效的化学探针,选择性地拮抗 EBI2 (也称为 GPR183),IC50 值为1.03 nM。ML401 在趋化性分析中显示活性 (IC50=6.24 nM)。ML401 表现出良好的稳定性,且无细胞毒性。
  4. GC31651 GSK682753A GSK682753A是EB病毒诱导受体2(EBI2)的反向激动剂,IC50值为53.6nM。
  5. GC14433 7α,25-dihydroxy Cholesterol 7α, 25-dihydroxycholesterol (7α,25-OHC) 是孤儿 GPCR 受体 EBI2 (GPR183) 的有效选择性激动剂和内源性配体。
  6. GC15430 NIBR189 NIBR189 是一种 EBI2(Epstein-Barr 病毒诱导基因 2)拮抗剂。

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