EBI2/GPR183

The Epstein-Barr virus (EBV) induced receptor 2 (EBI2; also known as GPR183) is an orphan member of the 7TM receptor family A. EBI2 is a constitutively active seven-transmembrane receptor. EBI2 has been placed in varying 7TM receptor subgroups by different phylogenetic analyses as being a target of peptide or lipid ligands. EBI2 constitutively activates extracellular signal-regulated kinase (ERK) in a pertussis toxin-insensitive manner. EBI2 is up-regulated up to 200-fold in B cells following EBV infection.

EBI2 activation stimulates immune cell migration and has been genetically linked to autoimmune diseases including type 1 diabetes. Small molecule modulators of EBI2 can be useful for probing the function of the receptor and its relevance to human diseases.

Cat.No. 产品名称 Information
GC65986 SAE-14 SAE-14 (compound SAE-14) 是一种有效、特异的 GPR183 拮抗剂，IC50值为 28.5 nM，可抑制 HL-60 细胞中 7α, 25-OHC 诱导的钙信号转导， IC50 值低于 50 nM。SAE-14 可逆转小鼠的异位性疼痛。
GC38820 ML401 ML401, a potent chemical probe, selectively antagonizes G-protein coupled receptor 183 (GPR183, EBI2) with an IC50 of 1.03 nM, and displays activity in a chemotaxis assay with IC50 of 6.24 nM.
GC31651 GSK682753A
GSK682753A是EB病毒诱导受体2(EBI2)的反向激动剂,IC50值为53.6nM。
GC14433 7α,25-dihydroxy Cholesterol A potent and selective agonist of GPR183
GC15430 NIBR189 A selective antagonist of EBI2 (GPR183)