TSH Receptor(促甲状腺激素受体)

The thyrotropin receptor (TSHR), one of the primary antigens in autoimmune thyroid disease, is a target of both antigen-specific T cells and antibodies in patients with this condition. Autoantibodies to the TSHR (TSHR-Ab) act as thyroid stimulating factor (TSH) agonists in autoimmune hyperthyroidism (Robert Graves disease) but as TSH antagonists in autoimmune hypothyroidism (Hashimoto thyroiditis). The TSHR antigen is primarily expressed in the epithelial cells of the thyroid follicles, but TSHR mRNA and protein have been reported in a variety of cell types, some of which show evidence of receptor activity.

TSH receptor (TSHR) plays an important role in the pathogenesis of thyroid disease, a TSHR antagonist could be a novel treatment.

TSH, acting through the TSH receptor, is the major stimulator of thyroid cell growth, differentiation and function.

Cat.No. 产品名称 Information
GC26016 TSHR antagonist S37 TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR).
GC65946 VA-K-14 hydrochloride
GC64079 NCGC00229600
GC62519 TSHR antagonist S37a
GC62506 TSHR antagonist S37b
GC60737 D3-βArr D3-βArr(NCGC00379308) is a positive allosteric modulator of thyrotropin receptor (TSHR) that modulates TSH-induced β-Arr 1 translocation.
GC19543 NCGC00379308 NCGC00379308 是促甲状腺激素受体 (TSHR) 的正变构调节剂，它通过直接激活 TSHR 启动 β-Arr 1 的易位，并在体外增强 TSH 介导的前成骨细胞分化。
GC32423 Org41841 A dual LH and TSH receptor agonist
GC31490 ML-109
GC12956 ML224 ML224(NCGC00242364; ANTAG3) 是一种选择性 TSHR 反向激动剂；抑制 TSH 刺激的 cAMP 产生，IC50 = 2.3 μM。