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TSHR antagonist S37

目录号 : GC26016

TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR).

TSHR antagonist S37 Chemical Structure

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5mg
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25mg
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Sample solution is provided at 25 µL, 10mM.

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产品描述

TSHR antagonist S37 is a selective and competitive antagonist of the thyrotropin receptor (TSHR).

TSHR antagonist S37 not only inhibits the thyrotropin receptor (TSHR) activation by thyrotropin itself but also activation by monoclonal TSAb M22 (human), KSAb1 (murine), and the allosteric small-molecule agonist C2. Disease-related ex vivo studies in HEK 293 cells expressing the TSHR shows that TSHR antagonist S37 also inhibits cyclic adenosine monophosphate formation by oligoclonal thyroid stimulating antibodies (TSAb).[1]

TSHR antagonist S37 has no toxicity and a remarkable 53% oral bioavailability in mice, indicating by initial in vivo pharmacokinetic studies.[1];

[1] Neumann S, et al. Eur Thyroid J. 2020 Dec;9(Suppl 1):59-65.

Chemical Properties

Cas No. 1217616-61-9 SDF Download SDF
分子式 C25H20N2O3S2 分子量 460.57
溶解度 储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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