GPCR19(G 蛋白偶联受体19)

GPCR19 is a G protein-coupled receptor for bile acid. Activation of this receptor induces its internalization and the production of intreacelluar cAMP. It is Involved in the suppression of macrophage function and regulation of energy homeostasis.

Cat.No. 产品名称 Information
GC46012 DY 268 An FXR antagonist
GC36319 INT-777 R-enantiomer INT-777 R-enantiomer 是 INT-77 的 R 型异构体，对 TGR5 的 EC50 值为 4.79 μM，活性比 INT-777 低。
GC40637 BAR501 A selective GP-BAR1 agonist
GC34775 SBI-115
SBI-115是一种TGR5(GPCR19)拮抗剂。SBI-115通过抑制TGR5降低多囊性肝病的肝囊肿形成。
GC33768 Deoxycholic acid sodium salt (Sodium deoxycholate) A secondary bile acid
GC33762 Deoxycholic acid (Cholanoic Acid) A secondary bile acid
GC32742 INT-767 INT-767是法尼醇X受体/TGR5双激动剂，平均EC50分别为30和630nM。
GC31370 SB756050 A TGR5 agonist
GC30565 BAR502 A dual agonist of GP-BAR1 and FXR
GC13681 INT-777
An agonist of TGR5
GC16363 TGR5 Receptor Agonist A TGR5 agonist
GN10489 Hyodeoxycholic acid A secondary bile acid