GPCR19(G 蛋白偶联受体19)
GPCR19 is a G protein-coupled receptor for bile acid. Activation of this receptor induces its internalization and the production of intreacelluar cAMP. It is Involved in the suppression of macrophage function and regulation of energy homeostasis.
- Cat.No. 产品名称 Information
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GC46012
DY 268
An FXR antagonist
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GC36319
INT-777 R-enantiomer
INT-777 R-enantiomer 是 INT-77 的 R 型异构体,对 TGR5 的 EC50 值为 4.79 μM,活性比 INT-777 低。
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GC40637
BAR501
A selective GP-BAR1 agonist
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GC34775
SBI-115
SBI-115是一种TGR5(GPCR19)拮抗剂。SBI-115通过抑制TGR5降低多囊性肝病的肝囊肿形成。
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GC33768
Deoxycholic acid sodium salt (Sodium deoxycholate)
A secondary bile acid
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GC33762
Deoxycholic acid (Cholanoic Acid)
A secondary bile acid
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GC32742
INT-767
INT-767是法尼醇X受体/TGR5双激动剂,平均EC50分别为30和630nM。
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GC31370
SB756050
A TGR5 agonist
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GC30565
BAR502
A dual agonist of GP-BAR1 and FXR
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GC13681
INT-777
An agonist of TGR5
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GC16363
TGR5 Receptor Agonist
A TGR5 agonist
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GN10489
Hyodeoxycholic acid
A secondary bile acid