GPR84 is a G protein-coupled receptor for medium-chain fatty acids. GPR84 is a receptor for free fatty acids and can be potently activated by saturated medium-chain free fatty acids (MCFAs) like decanoic acid, undecanoic acid and lauric acid. GPR84, a receptor for medium-length free fatty acids is upregulated on protein level in LPS activated tolerant CD14+ monocytes and THP-1 cells.
GPR84 is activated by MCFAs with the hydroxyl group at the 2- or 3-position more effectively than nonhydroxylated MCFAs. GPR84 is now considered to be a member of FFA-sensing GPCRs. MCFAs with carbon chain lengths of 9–14 activate GPR84, coupling primarily to a pertussis toxin (PTX)-sensitive Gi/o pathway. GPR84 should be a proinflammatory receptor and may be a novel, attractive target for treating chronic low grade inflammation associated-diseases.
- Cat.No. 产品名称 Information
- GC64229 GPR84 antagonist 1 GPR84 antagonist 1 是一种高亲和力、高选择性的人 GPR84 竞争性拮抗剂。
- GC31712 GPR84 antagonist 8 GPR84antagonist8是一种选择性GPR84拮抗剂。
- GC31698 PBI-4050 sodium salt (Setogepram (sodium salt)) Fezagepras (Setogepram) sodium 作为 GPR40 的口服活性激动剂和 GPR84 的拮抗剂或反向激动剂。
- GC11350 6-OAU 6-OAU (GTPL5846) (6-n-octylaminouracil) 是一种 GPR84（G 蛋白偶联受体 84）激动剂，EC50 值为 105 nM。