FFAR1 (GPR40)
GPR40 (Free fatty acid receptor 1, FFA1) is a class A G-protein coupled receptor that in humans is encoded by the FFAR1 gene. It is strongly expressed in the cells of the pancreas and to a lesser extent in the brain. This membrane protein binds free fatty acids, acting as a nutrient sensor for regulating energy homeostasis. GPR40 is activated by medium to long chain fatty acids. GPR40 is most strongly activated by eicosatrienoic acid, but has been found to be activated by fatty acids as small as 10 carbons long. For saturated fatty acids the level of activation is dependent on the length of the carbon chain, which is not true for unsaturated fatty acids. It has been found that three hydrophilic residues (arginine-183, asparagine-244, and arginine-258) anchor the carboxylate group of a fatty acid, which activates GPR40.
- Cat.No. 产品名称 Information
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GC63010
HWL-088
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GC36507
LY2922470
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GC36185
GPR40 Activator 1
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GC35364
AP5
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GC35314
AMG 837 sodium salt
An FFAR1 (GPR40) partial
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GC35313
AMG 837 calcium hydrate
An FFAR1 (GPR40) partial
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GC34464
AM-4668
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GC32481
Vincamine
A plant alkaloid with vasodilator effects
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GC31698
PBI-4050 sodium salt (Setogepram (sodium salt))
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GC31634
GPR40 Agonist 2
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GC31607
AM-1638
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GC31410
FAA1 agonist-1
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GC31389
GPR40 Activator 2
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GC19030
AMG 837
An FFAR1 (GPR40) partial
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GC18125
DC260126
An FFAR1 (GPR40) antagonist
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GC10922
TUG 424
A selective FFAR1 (GPR40) agonist
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GC16555
TAK-875
A selective FFAR1 (GPR40) agonist
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GC12401
GW9508
An agonist of GPR40
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GC16054
TUG-770
An agonist of FFA1/GPR40
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GC14027
GW-1100
A selective GPR40 antagonist