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GPCR/G protein

  1. Cat.No. Product Name Information
  2. GC38007 β-Melanocyte Stimulating Hormone (MSH), human TFA β-Melanocyte Stimulating Hormone (MSH), human TFA, 是一个 22 肽,是一种内源性黑皮质素-4 受体 (melanocortin-4 receptor; MC4-R) 激动剂。
  3. GC37983 β3-AR agonist 1 β3-AR agonist 1 (compound 15) 是一种高效选择性的,可口服的 β3-肾上腺素能受体 (β3-AR) 激动剂 (EC50=18 nM),对 β1-、β2-、α1A-AR 无活性 (β1/β3, β2/β3, α1A/β3>556倍)。
  4. GC40105 βARK1 Inhibitor βARK1 inhibitor is an inhibitor of G protein-coupled receptor kinase 2/β-adrenergic receptor kinase 1 (GRK2/βARK1; IC50 = 126 μM).
  5. GC61462 γ-1-Melanocyte Stimulating Hormone (MSH), amide γ-1-MelanocyteStimulatingHormone(MSH),amide是一种含11个氨基酸的多肽。γ-1-MelanocyteStimulatingHormone通过激活黑皮质素受体3(MC3-R)来调节钠(Na+)平衡和血压。
  6. GC17002 γ1-MSH melanocortin MC3 receptor agonist
  7. GC62708 σ1 Receptor antagonist-1 σ1 Receptor antagonist-1 是一种高效且选择性的 sigma 1 受体拮抗剂 (pKi=10.28)。σ1 Receptor antagonist-1 抑制细胞生长,在 G0/G1 期阻滞细胞周期并诱导 MCF-7/ADR 细胞凋亡 (apoptosis)。
  8. GC15519 α-CGRP (human)

    Endogenous calcitonin gene-related peptide receptor (CGRP) agonist

  9. GC11346 α-helical CRF 9-41 Antagonist of corticotropin releasing factor receptor
  10. GC11577 α-Methyl-5-hydroxytryptamine maleate 5-HT2B receptor agonist
  11. GC31237 α1 adrenoceptor-MO-1 α1adrenoceptor-MO-1是一种S型对映体,对alpha1adrenergicreceptor具有亲和性,可以抗α-肾上腺素能,同时能够止痛;比R型对映体的活性高。
  12. GC33681 β-Caryophyllene ((−)-trans-Caryophyllene) β-Caryophyllene是一个CB2受体激动剂。
  13. GC33693 β-Melanocyte Stimulating Hormone (MSH), human (Beta-MSH (1-22) (human)) β-MelanocyteStimulatingHormone(MSH),human是黑皮质素受体(melanocortin(MC)receptor)激动剂。
  14. GC31573 β3-AR agonist 2 β3-ARagonist2是一种有效的选择性β3肾上腺素能受体(β3-adrenergicreceptor,β3-AR)激动剂,EC50为8nM。
  15. GC34231 γ-1-Melanocyte Stimulating Hormone (MSH), amide γ-1-MelanocyteStimulatingHormone(MSH),amide是一种含11个氨基酸的多肽。γ-1-MelanocyteStimulatingHormone通过激活黑皮质素受体3(MC3-R)来调节钠(Na+)平衡和血压。
  16. GC17413 (±)-5'-Chloro-5'-deoxy-ENBA adenosine A1 receptor agonist, selective and high-affinity
  17. GC17408 (±)-AC 7954 hydrochloride urotensin-II (UT) receptor agonist
  18. GC15045 (±)-AMG 487 CXCR3 antagonist
  19. GC41668 (±)-Clopidogrel (hydrochloride) Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM).
  20. GC16838 (±)-Cloprostenol sodium salt prostaglandin F2α (PGF2α) analog,FP receptor agonist
  21. GC46283 (±)-Clorprenaline-d7
  22. GC18090 (±)-J 113397 NOP receptor antagonist
  23. GC62727 (±)-Penbutolol-d9 hydrochloride (±)-Penbutolol-d9 hydrochloride ((Rac)-Penbutolol-d9) 是一种氘标记的 (±)-Penbutolol hydrochloride。(±)-Penbutolol hydrochloride 是一种 β-肾上腺素受体拮抗剂,IC50 为 0.74 μM。
  24. GC15144 (±)-PPCC oxalate sigma (σ) receptor ligand
  25. GC10907 (±)-SLV 319 CB1 receptor antagonist,potent and selective
  26. GC12394 (±)-trans-ACPD

    metabotropic glutamate receptors agonist

  27. GC32523 (±)-Befunolol (±)-Befunolol是一种β-肾上腺素能受体阻断剂。
  28. GC34957 (+)-Cevimeline hydrochloride hemihydrate (_addition_)-Cevimeline盐酸水合物是mAChR激动剂。
  29. GC30743 (+)-Cloprostenol (D-Cloprostenol) (+)-Cloprostenol是前列腺素F2α的类似物,为选择性的prostaglandinreceptor激动剂。
  30. GC45259 (+)-Cloprostenol (sodium salt) (+)-Cloprostenol (sodium salt) is a more water soluble, crystalline form of (+)-cloprostenol.
  31. GC12750 (+)-Fluprostenol Prostaglandin F2α (FP) receptor agonist
  32. GC18146 (+)-Igmesine hydrochloride σ1 receptor ligand
  33. GC31597 (+)-Penbutolol ((R)-Penbutolol) (+)-Penbutolol是一种β肾上腺素拮抗剂,其IC50值为0.74μM.(+)-Penbutolol也是(-)-penbutolol的光学异构体,具有阻断Na+通道的作用。
  34. GC17301 (+)-SK&F 10047 hydrochloride prototypical σ1 receptor agonist
  35. GC10675 (+,-)-Octopamine HCl adrenoceptor agonist
  36. GC50245 (+/-)-ADX 71743 Negative allosteric modulator of mGlu7 receptors; brain penetrant
  37. GC50048 (+/-)-PPCC oxalate Selective sigma (σ) agonist (σ1> σ2)
  38. GC61646 (-)-Camphoric acid (-)-Camphoricacid是Camphoricacid的低活性异构体。Camphoricacid刺激成骨细胞分化并诱导谷氨酸受体(glutamatereceptor)表达。Camphoricacid还诱导NF-κB和AP-1活化。
  39. GC16919 (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 somatostatin sst2 receptor agonist
  40. GC34963 (1R,2S)-VU0155041 (1R,2S)-VU0155041是VU0155041的顺式异构体。(1R,2S)-VU0155041是mGluR4的部分激动剂,EC50值为2.35 μM。
  41. GC34965 (20S)-Protopanaxatriol (20S)-Protopanaxatriol 是人参皂苷的代谢物,通过 glucocorticoid receptor 和 oestrogen receptor 起作用,同时为 LXRα 的抑制剂。
  42. GC38712 (2R,3R)-E1R (2R,3R)-E1R (Compound 2b) 是 E1R 的一种对映异构体。(2R,3R)-E1R 是 sigma-1 受体的正变构调节剂 (Sig1R PAM),可用于治疗认知和记忆障碍。
  43. GC38713 (2R,3S)-E1R (2R,3S)-E1R (Compound 2c) 是 E1R 的一种对映异构体。(2R,3S)-E1R 是 sigma-1 受体的正变构调节剂 (Sig1R PAM),可用于治疗认知和记忆障碍。
  44. GC38714 (2S,3S)-E1R (2S,3S)-E1R (Compound 2d) 是 E1R 的一种对映异构体。(2S,3S)-E1R 是 sigma-1 受体的正变构调节剂 (Sig1R PAM),可用于治疗认知和记忆障碍。
  45. GC32644 (4E)-SUN9221 (4E)-SUN9221是一种有效的α1-adrenergicreceptor和5-HT2receptor拮抗剂,具有抗高血压和抗血小板聚集的功效。
  46. GA20063 (D-Ala²)-Gastric Inhibitory Polypeptide (human) GIP receptor agonist.
  47. GA20084 (Deamino-Cys¹,β-cyclohexyl-Ala⁴,Arg⁸)-Vasopressin Studies revealed that this specific vasopressin agonist exhibited a nanomolar affinity for V-1b receptors from various mammalian species (bovine, human, rat). It exhibited high V-1b/V-1a and V-1b/oxytocin selectivity for rat, human, and bovine receptors. Furthermore, it showed a high V-1b/V-2 specificity for both bovine and human vasopressin receptors. Therefore, d(Cha?)-AVP is a promising tool for research of V-1b receptor structure-function relationships.
  48. GA20195 (Gly¹,Ser³·²²,Gln⁴·³⁴,Thr⁶,Arg¹⁹,Tyr²¹,Ala²³·³¹,Aib³²)-Pancreatic Polypeptide (human) This (Ala-Aib)-containing pancreatic peptide/neuropeptide Y chimera is a highly selective neuropeptide Y? receptor agonist. At this receptor this compound turned out to be 25-fold more potent than the derivative H-5084 (0.24 nM vs 6 nM) and three-fold more potent than the native ligand neuropeptide Y (H-6375) (0.24 nM vs 0.6 nM). This analog turned out to increase feeding approximately 2.5-fold more effective than neuropeptide Y.
  49. GA20221 (Hyp³)-Bradykinin Bradykinin antagonist.
  50. GA20229 (Leu³¹,Pro³⁴)-Neuropeptide Y (human, rat) Specific Y? receptor agonist.
  51. GC11952 (R)-(+)-Atenolol less active enantiomer of the racemic β1-adrenergic receptor antagonist, (R,S)-atenolol.

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