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Home >> Signaling Pathways >> GPCR/G protein

GPCR/G protein(G 蛋白偶联受体/G 蛋白)

Cat.No. 产品名称 Information
GC13627 Ziprasidone hydrochloride monohydrate
盐酸齐拉西酮水合物; CP 88059 hydrochloride monohydrate
An atypical antipsychotic
GC11020 Ziprasidone
齐拉西酮; CP-88059
齐拉西酮 (CP-88059) 是一种口服活性抗精神病药，是一种 5-HT 和多巴胺受体拮抗剂的组合。
GC16270 WAY-100635 maleate salt
WAY 100635 maleate salt; WAY100635 maleate salt
A serotonin 5-HT_1A antagonist
GC10108 WAY-100635
WAY 100635; WAY100635
A serotonin 5-HT_1A antagonist
GC16312 Vortioxetine
沃替西汀; Lu AA 21004
A multimodal serotonergic agent
GC10876 Vilazodone Hydrochloride
盐酸维拉佐酮; EMD 68843 Hydrochloride; SB659746A Hydrochloride
An SSRI and a partial agonist of 5-HT_1A
GC15013 Vilazodone
维拉佐酮; EMD 68843; SB659746A
Vilazodone (EMD 68843; SB 659746A) 是一种强效、选择性和口服活性的血清素再摄取抑制剂 (SSRI) 和部分 5-HT1A 受体激动剂。
GC17421 Vicriviroc maleate
1-[(4,6-二甲基-5-嘧啶基)羰基]-4-[(3S)-4-[(1R)-2-甲氧基-1-[4-(三氟甲基)苯基]乙基]-3-甲基-1-哌嗪基]-4-甲基哌啶马来酸盐,Sch-417690; SCH-D
A CCR5 antagonist
GC11238 Verlukast
MK-679; L 668019;MK-0679;MK0679;L668019;L-668019
Leukotriene D4 antagonist
GC11831 Umeclidinium bromide
芜地溴铵; GSK573719A
A muscarinic acetylcholine receptor antagonist
GC16054 TUG-770
TUG770;TUG 770
An agonist of FFA1/GPR40
GC15973 Tozadenant
4-羟基-N-[4-甲氧基-7-(4-吗啉基)-2-苯并噻唑基]-4-甲基-1-哌啶甲酰胺,SYN-115;SYN115;SYN 115
An adenosine A_2A receptor antagonist
GC12554 Tiotropium Bromide
噻托溴铵; BA679 BR
A muscarinic receptor antagonist
GC14788 Tianeptine
噻奈普汀
An atypical antidepressant
GC15574 Taranabant
N-[(1S,2S)-3-(4-氯苯基)-2-(3-氰基苯基)-1-甲基丙基]-2-甲基-2-[(5-(三氟甲基)吡啶-2-基)氧基]丙酰胺,MK-0364;MK0364;MK 0364
A CB₁ receptor inverse agonist
GC16026 Talnetant
SB-223412;SB223412;SB 223412
A nonpeptide NK₃ antagonist
GC18123 TAK-700 salt
TAK 700 (salt); TAK700 (salt)
Androgen synthesis inhibitor
GC16377 SRT3190
N-[2-[[(2,3-二氟苯基)甲基]硫基]-6-[[(1S,2R)-2,3-二羟基-1-甲基丙基]氨基]-4-嘧啶基]-1-氮杂环丁烷磺酰胺,SRT 3190;SRT-3190
SRT3190 是 CXCR2 的拮抗剂，用于研究趋化因子介导的疾病。
GC16710 SRT3109
SRT 3109;SRT-3109
SRT3109 是 CXCR2 的拮抗剂，pIC50 为 8.2，用于研究趋化因子介导的疾病。
GC13549 Setiptiline maleate
马来酸司普替林; MO-8282
Setiptiline maleate (MO-8282 maleate) 是一种血清素受体拮抗剂。
GC13990 Setiptiline
司普替林; Org-8282
Setiptiline (Org-8282) 是一种血清素受体拮抗剂。
GC11517 SEA0400
2-[4-[(2,5-二氟苯基)甲氧基]苯氧基]-5-乙氧基苯胺,SEA 0400;SEA-0400
A selective inhibitor of the Na⁺/Ca²⁺ exchanger
GC15401 SCH 563705
3-[[3-[(二甲氨基)羰基]-2-羟苯基]氨基]-4-[[(R)-1-(4-异丙呋喃-2-基)丙基]氨基]环丁基-3-烯-1,2-二酮,SCH563705;SCH-563705
SCH 563705 是一种有效的、可口服的 CXCR2 和 CXCR1 拮抗剂，IC50 分别为 1.3 nM、7.3 nM 和 Kis 分别为 1 和 3 nM。
GC16100 SCH 527123
3-[[3-[(二甲基氨基)羰基]-2-羟基苯基]氨基]-4-[[(R)-1-(5-甲基呋喃-2-基)丙基]氨基]-3-环丁烯-1,2-二酮,SCH-527123;SCH527123
An allosteric antagonist of CXCR1 and CXCR2
GC15534 SB-674042
(S)-1-[5-[2-氟苯基]-2-甲基噻唑-4-基]-1-[2-[[5-苯基-[1,3,4]恶二唑-2-基]甲基]吡咯烷-1-基]甲酮,SB 674042; SB674042
A potent and selective orexin 1 receptor antagonist
GC16540 SB-408124 Hydrochloride
N-(6,8-二氟-2-甲基-4-喹啉基)-N'-[4-(二甲基氨基)苯基]脲盐酸盐,SB 408124 Hydrochloride;SB408124 Hydrochloride
A potent orexin 1 receptor antagonist
GC10107 SB-222200
3-甲基-2-苯基-N-((1S)-1-苯基丙基)喹啉-4-甲酰胺,SB 222200;SB222200
An NK₃ receptor antagonist
GC11531 Salmeterol xinafoate
沙美特罗昔萘酸酯; GR 33343X xinafoate
A long-acting β₂-adrenergic receptor agonist
GC12188 Salmefamol
AH 3923;AH-3923; AH3923

β2-adrenergic receptor agonist
GC10528 Salirasib
法尼基硫代水杨酸; S-Farnesylthiosalicylic acid; Farnesyl Thiosalicylic Acid; FTS
A Ras inhibitor with anti-cancer and anti-atherogenic activity
GC15489 RS 504393
6-甲基-1,1'-[2-(5-甲基-2-苯基-4-恶唑基)乙基]-螺[4H-3-1,1-苯并恶嗪-4,4'-哌啶]-2(1H)-酮,RS-504393; RS504393
A CCR2 chemokine receptor antagonist
GC11729 RS 127445
2-氨基-4-(4-氟萘-1-基)-6-异丙基嘧啶,RS-127445; MT 500; RS127445
A 5-HT_2B receptor antagonist
GC16017 Rotigotine hydrochloride
罗替戈汀盐酸盐; N-0923 Hydrochloride
A non-selective dopamine receptor agonist
GC10614 Rotigotine
罗替戈汀; N-0437; N-0923
A non-selective dopamine receptor agonist
GC16466 Rimonabant hydrochloride
盐酸利莫那班; SR 141716A Hydrochloride
A potent and selective CB₁ receptor antagonist
GC13813 Reparixin L-lysine salt
REPERTAXINL-赖氨酸盐,Repertaxin L-lysine salt
Perifosine is an orally active alkyl phospholipid analogue that has shown antitumor activity in a variety of cancers by interfering .
GC12849 Reparixin
瑞帕利辛; Repertaxin; DF 1681Y
An allosteric inhibitor of CXCR1 and CXCR2
GC14167 Quetiapine
喹硫平; ICI204636
Quetiapine是一种5-HT受体激动剂，对人类5-HT1A受体的 pEC₅₀为4.77。Quetiapine是一种多巴胺受体拮抗剂，对人类D2受体的pIC₅₀为6.33。Quetiapine是一种非典型抗精神病药，用于治疗精神分裂症、躁郁症和重度抑郁症。
GC11591 Preladenant
瑞德南特,SCH-420814;SCH 420814;SCH420814
An adenosine A_2A receptor antagonist
GC17976 Phloretin
根皮素; NSC 407292; RJC 02792
A natural inhibitor of various transporters
GC11917 PF-543
(2R)-1-[[4-[[3-甲基-5-[(苯磺酰基)甲基]苯氧基]甲基]苯基]甲基]-2-吡咯烷甲醇,PF543; PF 543
PF-543是一种强效、选择性、可逆和鞘氨醇竞争性SphK 1抑制剂，IC50值为2nM，Ki值为3.6 nM。
GC12200 Pentostatin
喷司他丁; CI-825; Deoxycoformycin
Pentostatin（2'-deoxycoformycin, Nipent）是一种腺苷脱氨酶抑制剂，K_i为1.2pM，IC₅₀为1.4pM 。
GC17384 PD 123319 ditrifluoroacetate
PD123319二(三氟乙酸盐),PD123319 ditrifluoroacetate;PD-123319 ditrifluoroacetate
A selective angiotensin II type 2 receptor antagonist
GC10843 Otenabant
奥替那班,CP 945598;CP-945598;CP945598
Otenabant 是一种有效的选择性大麻素受体 CB1 拮抗剂，Ki 为 0.7 nM，对人 CB2 受体的选择性高 10,000 倍。
GC16886 Orteronel
6-[(7S)-7-羟基-6,7-二氢-5H-吡咯并[1,2-C]咪唑-7-基]-N-甲基-2-萘甲酰胺,TAK-700 (S-form)
A non-steroidal inhibitor of the 17,20-lyase activity of CYP17A1
GC15662 ONO-AE3-208
4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸,AE 3-208;ONO AE3 208
An EP₄ receptor antagonist
GC16936 Olmesartan
奥美沙坦; RNH-6270
An AT₁ receptor antagonist and active metabolite of olmesartan medoxomil
GC10899 Octreotide acetate
奥曲肽; SMS 201-995
A somatostatin receptor agonist
GC12240 NPS-2143 hydrochloride
2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈盐酸盐,NPS2143 hydrochloride;NPS 2143 hydrochloride
An orally-active CaSR antagonist
GC11871 MTEP hydrochloride
3-[2-(2-甲基-4-噻唑基)乙炔基]吡啶盐酸盐
A selective mGlu5a receptor antagonist