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Home >> Signaling Pathways >> GPCR/G protein

GPCR/G protein(G 蛋白偶联受体/G 蛋白)

Cat.No. 产品名称 Information
GC19339 SSR240612 SSR240612是一种新的、有效的、具有口服活性的特异性非肽慢激肽B1受体拮抗剂，可抑制Lys0-desAr9-BK (10nM) 诱导的人成纤维细胞MRC5中肌醇单磷酸的形成，IC₅₀为1.9nM。
GC19327 Setipiprant
司替匹仑,ACT-129968; KYTH-105
An antagonist of CRTH₂/DP₂
GC19323 SB-649868
GSK649868
A dual orexin receptor antagonist
GC19316 S1p receptor agonist 1
S1p receptor agonist 1
S1p receptor agonist 1 是一种有效且具有口服活性的 S1P 受体激动剂，具有诱导 S1P1 内化的活性 (EC50=9.83 nM)。
GC19294 Piboserod
哌波色罗,SB-207266
A selective, potent 5-HT₄ receptor antagonist
GC19272 Orexin 2 Receptor Agonist
OX2R
An orexin 2 receptor agonist
GC19258 Nastorazepide
Z-360
Nastorazepide (Z-360) 是一种选择性的口服 1,5-苯二氮卓衍生物胃泌素/胆囊收缩素 2 (CCK-2) 受体拮抗剂，具有潜在的抗肿瘤活性。
GC19255 MSX-122 A partial antagonist of CXCR4
GC19250 MK-3697 An orexin receptor 2 antagonist
GC19249 MK-1064 An orexin 2 receptor antagonist
GC19239 Mapracorat
ZK-245186; BOL-303242X
Mapracorat 是一种新型非甾体选择性糖皮质激素受体激动剂。
GC19231 LY2828360 A selective CB₂ receptor agonist
GC19230 LY2510924 LY2510924 是一种有效的选择性 CXCR4 拮抗剂；阻断 SDF-1 与 CXCR4 的结合，IC50 为 0.079 nM。
GC19220 Lemborexant
莱博雷生,E-2006
Lemborexant (E2006) 是一种口服活性双食欲素受体拮抗剂 (DORA)，已获得美国食品和药物管理局批准用于治疗失眠。
GC19209 JNJ-63533054
3-氯-N-[2-氧代-2-[[(1S)-1-苯基乙基]氨基]乙基]苯甲酰胺
JNJ-63533054 是一种有效的选择性 hGPR139 激动剂，EC50 = 16nM。
GC19207 JNJ-42153605 A positive allosteric modulator of mGlurR2
GC19197 IB-MECA
IB-MECA; CF-101
An adenosine A₃ receptor agonist
GC19176 GSK163090 GSK163090 是一种有效的、选择性的和具有口服活性的 5-HT1A/1B/1D 受体拮抗剂，pKi 值分别为 9.4/8.5/9.7。
GC19170 Glucagon receptor antagonists-4
Glucagon receptor antagonists-4
A GCGR antagonist
GC19164 GGTI298 Trifluoroacetate A geranylgeranyltransferase I inhibitor
GC19153 Fevipiprant
非韦匹仑,QAW039; NVP-QAW039
A DP₂/CRTH₂ antagonist
GC19147 Evatanepag
2-[3-[N-(4-叔丁基苄基)-N-(吡啶-3-基磺酰基)氨基甲基]苯氧基]乙酸,CP-533536 free acid
Evatanepag (CP-533536) 是一种非前列腺素、强效和选择性 EP2 受体激动剂。
GC19146 Etrasimod
APD334
A potent S1P₁, S1P₄, and S1P₅ receptor antagonist
GC19137 EMA401
EMA401; PD-126055
A selective AT₂ receptor antagonist
GC19116 Danirixin
GSK1325756
A CXCR2 antagonist
GC19101 Cenicriviroc
TAK-652; TBR-652
Cenicriviroc (CVC) 是一种口服的 CCR2/CCR5 双重拮抗剂，对这两种受体具有纳摩尔效力。
GC19100 Cenerimod
ACT-334441
A S1P₁ receptor modulator
GC19087 Capromorelin Tartrate
卡普瑞林酒石酸盐,CP 424391-18
A growth hormone secretagogue and GHS-R1a agonist
GC19081 BPTU
BMS-646786
A P2Y₁ receptor antagonist
GC19078 BMS-986020
AM152
An LPA₁ receptor antagonist
GC19077 BMS-813160 A dual antagonist of CCR2 and CCR5
GC19071 BIBS 39 A nonpeptide AT₁ receptor antagonist
GC19060 Bay 59-3074 A partial agonist of CB₁ and CB₂ receptors
GC19051 AZD7594
AZD7594; AZ13189620
AZD7594 是一种有效的选择性非甾体糖皮质激素受体调节剂，IC50 为 0.9 nM。
GC19049 AZD4635
HTL1071; AZD4635
An adenosine A₂ receptor antagonist
GC19037 ARS-853 An inhibitor of KRAS^G12C
GC19033 APD597
JNJ-38431055
An agonist of GPR119
GC19032 AVex-73 hydrochloride
Anavex 2-73
AVex-73 hydrochloride 是一种 Sigma-1 Receptor 激动剂，IC50 为 860 nM。
GC19031 Amiselimod hydrochloride
MT-1303盐酸盐,MT-1303 hydrochloride
A prodrug form of amiselimod phosphate
GC19030 AMG 837
(BETAS)-BETA-1-丙炔-1-基-4-[[4'-(三氟甲基)[1,1'-联苯]-3-基]甲氧基]苯丙酸
An FFAR1 (GPR40) partial
GC19023 AF38469 An inhibitor of sortilin
GC18951 Obscurolide A1 A phosphodiesterase inhibitor
GC18873 URB447 An Analytical Reference Standard
GC18867 SER-601 A selective CB₂ receptor agonist
GC18866 MCHB-1
NMethylcyclohexyl benzimidazole analog 1
A CB₂ receptor agonist
GC18719 Docosatetraenoyl Ethanolamide
DEA

An endocannabinoid
GC18678 CAY10595 A potent CRTH2/DP₂ receptor antagonist
GC18661 Vercirnon
维塞诺; GSK-1605786; CCX282-B; Traficet-EN
An antagonist of CCR9
GC18648 Echothiophate (iodide)
碘依可酯,Echothiophate iodide
An AChE inhibitor
GC18501 Kendomycin
(-)-TAN2162
A cytotoxic macrolide