Metabolism(代谢)

Cat.No. 产品名称 Information

GC52315 GK241 An sPLA₂ (Type IIA) inhibitor

GC52304 Perfluoroheptanoic Acid

PFHpA

A perfluoroalkyl substance

GC52290 (R)-HTS-3 An inhibitor of LPCAT3

GC52278 Creatine Phosphate (sodium salt hydrate)

Phosphocreatine

A phosphorylated form of creatine

GC52257 Perfluorohexanoic Acid

Perfluorocaproic Acid, PFHxA, Undecafluorocaproic Acid, Undecafluorohexanoic Acid

A perfluoroalkyl substance

GC52253 α-Enolase (1-19)-biotin Peptide

Enolase-1 (1-19)-biotin

A biotinylated α-enolase peptide

GC52251 Imidacloprid Impurity 1 A potential impurity in commercial preparations of imidacloprid

GC52231 Heptadecanoyl-L-carnitine-d3 (chloride)

CAR 17:0-d3, C17:0 Carnitine-d3, L-Carnitine heptadecanoyl ester-d3, L-Heptadecanoylcarnitine-d3

An internal standard for the quantification of heptadecanoyl-L-carnitine

GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone

(±)-δ-(3,4-Dihydroxyphenyl)-γ-Valerolactone, 5-(3',4'-Dihydroxyphenyl)-γ-VL

An active metabolite of various polyphenols

GC52219 Heptadecanoyl-L-carnitine (chloride)

CAR 17:0, C17:0 Carnitine, L-Carnitine heptadecanoyl ester, L-Heptadecanoylcarnitine

A long-chain acylcarnitine

GC52214 Nicotinamide riboside-d4 (triflate) An internal standard for the quantification of nicotinamide riboside

GC20109 Cefotiam hexetil hydrochloride

盐酸头孢替安酯; CTM-HE hydrochloride; SCE-2174 hydrochloride

Cefotiam hexetil hydrochloride 是可口服的第三代头孢菌素，是 cefotiam 的前药，但无抗菌作用。Cefotiam 是一种抗生素。

GC20095 5,7-Dihydroxy-4-methylcoumarin

NSC 5302

A synthetic coumarin with diverse biological activities

GC20091 α-Arbutin

α-熊果苷; 4-Hydroxyphenyl α-D-glucopyranoside

A glycosylated hydroquinone with diverse biological activities

GC67661 S-2E S-2E 是一种具有口服活性且非竞争性的 HMG-CoA 还原酶和乙酰-CoA 羧化酶 (acetyl-CoA carboxylase) 抑制剂。S-2E 具有抗高血脂作用，可用于家族性高胆固醇血症和混合性高脂血症的研究。

GC67211 BAPTA tetrapotassium

BAPTA四钾盐

An extracellular calcium chelator

GC66645 L-Adenosine

L-腺苷

L-Adenosine 是一种代谢稳定的对映异构体类似物，也是一种潜在的探针。L-Adenosine 具有弱抑制性腺苷脱氨酶 (ADA) 活性，Ki 值为 385 μM。L-Adenosine 可用于腺苷摄取和积累的研究。

GC66450 sEH inhibitor-7 sEH inhibitor-7 (compound c-2) 是一种可溶性环氧化物水解酶 (sEH) 抑制剂，IC50 分别为 0.15 μM (mouse sEH)和6.2 μM (human sEH)。可溶性环氧化物水解酶 (sEH) 在调节血压和炎症的内源性化学介质的代谢中起着重要作用。

GC66360 Girentuximab

G250; cG250

Girentuximab (G250) 是一种嵌合单克隆抗体，可与碳酸酐酶 IX (CAIX) 结合，碳酸酐酶 IX 是一种在透明细胞肾细胞癌 (ccRCC) 中广泛表达的细胞表面糖蛋白。

GC66197 α-?Terpinyl acetate Terpinyl Acetate (alpha-Terpinyl), a naturally occuring compound found in several essential oils, is a flavouring agent.

GC66059 YZ129 YZ129 是 HSP90-磷酸酶-NFAT 通路的抑制剂，可抗胶质母细胞瘤，直接与热休克蛋白 (HSP90) 结合，对NFAT核易位的 IC50 值为820 nM。YZ129 在 G2/M 期诱导GBM细胞周期阻滞，促进细胞凋亡，抑制肿瘤细胞增值和迁移。

GC66042 Enpp-1-IN-14 ENPP1-IN-2 是一种有效的外核苷酸焦磷酸酶/磷酸二酯酶 (ENPP1) 抑制剂，对重组人 ENPP-1 的 IC50 为 32.38 nM。ENPP1-IN-2 具有抗肿瘤活性。

GC66029 hCAI/II-IN-6 hCAI/II-IN-6 是一种具有口服活性的 human carbonic anhydrase (CA) 抑制剂。hCAI/II-IN-6 选择性地抑制 hCA II 和 hCA VII，对 hCA I，hCA II，hCA VII 和 hCA XII 的 Ki 值分别为 220，4.9，6.5 和＞50000 nM。hCAI/II-IN-6 在体内显示抗惊厥活性和抗最大电击 (MES) 活性。hCAI/II-IN-6 可以用于癫痫的研究。

GC66015 IHVR-11029 IHVR-11029 是ER α-glucosidases 的抑制剂，其 EC50 值为0.09 μM。

GC66005 CVT-11127

GS-456332

CVT-11127 (FMK13918) is an inhibitor of stearoylCoA desaturase-1 (SCD1). CVT-11127 reduces lipid synthesis and impaires proliferation by blocking the progression of cell cycle through the G(1)/S boundary and by triggering programmed cell death.

GC65930 Vitamin K3-d8

维生素K3-d8

Vitamin K3-d8 是 Vitamin K3 的氘代物。

GC65925 TDP1 Inhibitor-1 TDP1 Inhibitor-1 是一种酪酰 DNA 磷酸二酯酶 1 (TDP1) 有效抑制剂，IC50 值为 7 μM。

GC65912 Asundexian

BAY-2433334

Asundexian (BAY 2433334) 是一种口服活性凝血因子 FXIa 抑制剂。Asundexian 直接、有效、可逆地结合 FXIa 的活性位点，从而抑制其活性。Asundexian 抑制缓冲液中的人 FXIa 的 IC50 为 1 nM。

GC65911 Irsenontrine

E2027

Irsenontrine (E2027) 是一种具有口服活性和选择性的磷酸二酯酶 9 (PDE9) 抑制剂。Irsenontrine (E2027) 可用于神经系统疾病的研究。

GC65895 IDO1-IN-19 IDO1-IN-19 (Compound 17) 是一种有效的 IDO1 抑制剂。IDO1-IN-19 具有研究癌症疾病的潜力。

GC65612 Acetazolamide sodium

乙酰唑胺钠

An Analytical Reference Standard

GC20062 trans-3'-Hydroxycotinine

3'R,5'S)-3'-羟基可替宁,3HC

A metabolite of nicotine

GC20027 (±)5(6)-DiHET MaxSpec® Standard

(±)5,6-DiHETrE

5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET by epoxide hydrolases.

GC52194 Dimethylamino Parthenolide

DMAPT, LC-1

An inhibitor of NF-κB

GC52190 Imidazole Ketone Erastin

IKE

Imidazole Ketone Erastin是一种有效的、代谢稳定的系统xc- 抑制剂和铁凋亡诱导剂。

GC52189 Nomegestrol

诺美孕酮

A derivative of 19-norprogesterone

GC52170 2-Nitroamino-2-imidazoline

2-硝基亚氨基咪唑烷

An intermediate in the synthesis of imidacloprid

GC52164 Cu-ATSP

copper-ATSP, CuII(atsp)

A copper-containing bis(thiosemicarbazone) complex

GC52159 N-methyl Tyramine (hydrochloride)

4-[2-(甲基氨基)乙基]苯酚盐酸盐

A phenethylamine alkaloid with antilipolytic activity

GC52149 306-O12B 306-O12B是一种可电离的阳离子脂质，用于生成脂质纳米颗粒(LNPs)。

GC52139 NG-497 An ATGL inhibitor

GC52138 Pantoic Acid

右泛醇杂质B

An intermediate in the biosynthesis of D-pantothenic acid

GC52132 N-desmethyl Diltiazem (hydrochloride)

盐酸地尔硫卓杂质D

An active metabolite of diltiazem

GC52129 3-Amino-5-hydroxybenzoic Acid

3-氨基-5-羟基苯甲酸

A biosynthetic precursor to ansamycin antibiotics

GC52126 8-chloro Caffeine

茶苯海明相关物质E

A derivative of caffeine

GC52125 T-1095 An SGLT1 and SGLT2 inhibitor

GC20007 Ginsenoside CK

20(S)-人参皂苷 C-K; Compound K

Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and COX-2. Ginsenoside C-K exhibits an inhibition against the activity of CYP2C9 and CYP2A6 in human liver microsomes with IC50s of 32.0±3.6 μM and 63.6±4.2 μM, respectively.

GC65595 3-Nitrocoumarin 3-Nitrocoumarin (3-NC) 是一个有效的、磷脂酶 C-γ (PLC-γ) 的选择性抑制剂。

GC65549 Indisulam

N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺,E 7070

A sulfonamide with anticancer activity

GC65517 4-(Trifluoromethyl)umbelliferone

7-羟基-4-三氟甲基香豆素

4-(Trifluoromethyl)umbelliferone 是大鼠肝细胞色素 P450 酶的荧光探针底物。